Article
Nutrition & Dietetics
Tingting Sha, Wei Li, Hongyi He, Jing Wu, Yilun Wang, Hui Li
Summary: This study found that a genetically higher concentration of iron is associated with an increased risk of sarcopenia, suggesting that iron may play a role in the occurrence or development of sarcopenia.
FRONTIERS IN NUTRITION
(2022)
Article
Rehabilitation
Zeynep Aykin Yigman, Ebru Umay, Damla Cankurtaran, Sukran Guzel
Summary: This study investigated the presence of dysphagia in older adults and found a significantly higher number of patients with dysphagia in this group, as well as significantly lower sarcopenic evaluation parameters. Older adults with dysphagia were also less likely to have malnutrition.
INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Jiyong Yang, Peng Liu, Shuai Wang, Tao Jiang, Yilong Zhang, Wengang Liu
Summary: This study investigated the causal associations between osteoarthritis (OA) and sarcopenia (SP) using a bi-directional Mendelian randomization approach. The findings suggest that changes in muscle composition may have a causal effect on OA, while there is little evidence for the causal effect of OA on SP.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Kazuki Fukuma, Masatoshi Kamada, Kazuya Yamamoto, Chiaki Yokota, Soichiro Abe, Shinsaku Nakazawa, Tomotaka Tanaka, Takuro Chichikawa, Yuriko Nakaoku, Kunihiro Nishimura, Masatoshi Koga, Shigetoshi Takaya, Ken Sugimoto, Shinta Nishioka, Hidetaka Wakabayashi, Ichiro Fujishima, Masafumi Ihara
Summary: This study aimed to investigate the associations of pre-existing sarcopenia with swallowing function, oral intake level, and aspiration pneumonia in patients with acute stroke. The results showed that compared with the control group, the sarcopenia group had significantly lower tongue pressure and a higher prevalence of dysphagia, and was more likely to have impaired oral intake and aspiration pneumonia during hospitalization. This suggests that acute stroke patients with sarcopenia may have weakness of the swallowing-related muscles, leading to impaired oral intake and aspiration pneumonia.
CLINICAL NUTRITION
(2023)
Review
Geriatrics & Gerontology
Chun-wei Li, Kang Yu, Ng Shyh-Chang, Zongmin Jiang, Taoyan Liu, Shilin Ma, Lanfang Luo, Lu Guang, Kun Liang, Wenwu Ma, Hefan Miao, Wenhua Cao, Ruirui Liu, Ling-juan Jiang, Song-lin Yu, Chao Li, Hui-jun Liu, Long-yu Xu, Rong-ji Liu, Xin-yuan Zhang, Gao-shan Liu
Summary: Age-associated obesity and muscle atrophy are closely linked and regulated by adipose tissue and skeletal muscle dysfunction. Adipose inflammation leads to fat redistribution and fatty infiltrations in muscles, causing decreased strength and functionality. Lipid accumulation induces mitochondrial dysfunction, increased production of reactive oxygen species, leading to lipotoxicity and insulin resistance. Muscle-secreted cytokines may exacerbate adipose tissue atrophy and chronic inflammation, establishing a vicious cycle of local hyperlipidaemia, insulin resistance, and inflammation, promoting the development of sarcopenic obesity.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Multidisciplinary Sciences
Nareudee Limpuangthip, Orapin Komin, Teerawut Tatiyapongpaiboon
Summary: This study developed a Thai-version simple swallowing questionnaire called T-SSQ to evaluate swallowing ability in older adults, and found that self-reported swallowing problems and objective tongue strength were associated with malnutrition risk. The subjective index estimated malnutrition risk better than the objective index.
Article
Geriatrics & Gerontology
A. Shimizu, Keisuke Maeda, H. Wakabayashi, S. Nishioka, T. Ohno, A. Nomoto, J. Kayashita, I. Fujishima
Summary: This study aimed to investigate the clinical characteristics of patients with possible and probable sarcopenic dysphagia, categorizing patients based on tongue pressure into probable and possible groups. The results showed that patients with probable sarcopenic dysphagia exhibited poorer swallowing ability and activities of daily living compared to those with possible sarcopenic dysphagia.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Geriatrics & Gerontology
Sara Salini, Andrea Russo, Riccardo Calvani, Marcello Covino, Anna Maria Martone, Matteo Tosato, Francesco Paolo Damiano, Anna Picca, Emanuele Marzetti, Francesco Landi
Summary: There is a correlation between the personal perception of physical performance and the presence of sarcopenia. Individuals who perceive difficulty in walking 400 m have a higher risk of sarcopenia.
Article
Multidisciplinary Sciences
Kuei-Ru Chou, Mao-Suan Huang, Wan-Chun Chiu, Yi-Hsiu Chen, Yu-Yoh Chen, Qian Xiao, Suh-Ching Yang
Summary: Declines in oral consumption and swallowing function can increase the risk of malnutrition in older adults. A comprehensive assessment of oral health, swallowing function, and nutritional status is important for long-term care residents.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Akio Shimizu, Ichiro Fujishima, Keisuke Maeda, Hidetaka Wakabayashi, Shinta Nishioka, Tomohisa Ohno, Akiko Nomoto, Takashi Shigematsu, Jun Kayashita
Summary: Low tongue pressure in probable sarcopenic dysphagia may negatively impact swallowing function improvement and severe malnutrition, indicating the need for aggressive nutritional therapy for these patients.
Article
Geriatrics & Gerontology
Sehoon Park, Seong Geun Kim, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: Through genetic analysis, it has been found that smoking is causally related to various aging traits, and smoking is associated with poor aging and frailty. This finding is important for further understanding the impact of smoking on human health.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Geriatrics & Gerontology
Mingchong Liu, Daqian Yu, Yutao Pan, Shengchao Ji, Ning Han, Chensong Yang, Guixin Sun
Summary: This study conducted a two-sample Mendelian randomization and found causal associations between coffee intake, education years, smoking, leisure screen time, and moderate-to-vigorous intensity physical activity during leisure time and sarcopenia. These findings may provide new intervention strategies for preventing sarcopenia.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Nutrition & Dietetics
Magali Gonzalez-Colaco Harmand, Alicia Tejera Concepcion, Francisco Jose Farrais Exposito, Jennifer Dominguez Gonzalez, Yolanda Ramallo-Farina
Summary: Sarcopenia and malnutrition have been found to be associated with poor prognosis in wound healing and other adverse events in the elderly population. A prospective study on elderly patients with diabetic foot showed that malnutrition and sarcopenia were related to pain, quality of life, mobility, and healing outcomes.
Article
Medicine, General & Internal
Ramin Heshmat, Gita Shafiee, Afshin Ostovar, Noushin Fahimfar, Saba Maleki Birjandi, Mohammad Jabbari, Farshad Sharifi, Iraj Nabipour, Bagher Larijani
Summary: In Iranian older adults, sarcopenia is associated with ECG abnormalities, with sarcopenia patients having a higher risk of major ECG abnormalities in the full model; both low muscle strength and low muscle performance are also associated with an increased risk of major ECG abnormalities.
FRONTIERS IN MEDICINE
(2021)
Article
Business, Finance
Myeong Jun Kim, Nguyen Phuc Canh, Sung Y. Park
Summary: The study uses Granger non-causality test in quantiles to analyze the causal relationships among cryptocurrencies. The results show varying degrees of causality among cryptocurrencies at different quantile levels, with stronger relationships at higher quantile levels, posing challenges for investors to hedge risks in the cryptocurrency market.
FINANCE RESEARCH LETTERS
(2021)
Article
Nutrition & Dietetics
Junko Ueshima, Keisuke Maeda, Akio Shimizu, Ayano Nagano, Yuria Ishida, Tomoko Takeuchi, Tomoyuki Nonogaki, Remi Matsuyama, Yosuke Yamanaka, Kenta Murotani, Naoharu Mori
Summary: This study aimed to validate the cachexia staging score (CSS) as a diagnostic method for measuring cachexia severity in patients with advanced cancer receiving palliative care. The results showed that as the severity of cachexia increased, patients had shorter survival and experienced changes in symptoms and biomarkers associated with cachexia.
Review
Oncology
Ryuichi Nakahara, Keisuke Maeda, Sho Aki, Tsuyoshi Osawa
Summary: Cancer cells are highly heterogeneous and adapt to harsh tumor microenvironments through genetic, epigenetic, and metabolic alterations. The metabolic adaptation allows cancer cells to evade death, immune responses, and develop drug resistance. Understanding metabolic adaptations of malignant cancer cells within tumor microenvironments is crucial for developing effective cancer therapies. Recent studies have shown that cell-cell and organelle-organelle interactions play essential roles in the metabolic adaptation of cancer cells, offering new targets for cancer treatment.
Review
Nutrition & Dietetics
Junko Ueshima, Ayano Nagano, Keisuke Maeda, Yoshiko Enomoto, Koshi Kumagai, Rie Tsutsumi, Naoki Higashibeppu, Yu Uneno, Joji Kotani
Summary: This systematic review examined the recommendation of nutritional counseling for adult patients with incurable advanced or recurrent cancer. The results showed that nutritional counseling can improve energy and protein intake in these patients, but its impact on quality of life is unclear. Further research is needed to determine the effectiveness of nutritional counseling in cancer patients.
CLINICAL NUTRITION
(2023)
Article
Chemistry, Analytical
Takaaki Higashi, Naoki Ogawa, Keisuke Maeda, Takahiro Ogawa, Miki Haseyama
Summary: This study proposes a method for distress image classification in road infrastructures using self-supervised learning. Contrastive learning is utilized to provide a domain-specific representation of distress images, enabling the improvement of classification performance. The proposed method is validated using real-world distress images, demonstrating its effectiveness for various distress types.
Review
Nutrition & Dietetics
Tatsuro Inoue, Junko Ueshima, Fumiya Kawase, Haruko Kobayashi, Ayano Nagano, Kenta Murotani, Yoko Saino, Keisuke Maeda
Summary: Interventions for stroke-related sarcopenia are needed, but the target population is unclear. This systematic review identified prevalence trajectories and diagnostic criteria for sarcopenia in patients with stroke. Most studies included Asian patients and used the Asian Working Group for Sarcopenia criteria. Prevalence of sarcopenia increased by approximately 15% from pre-stroke to 10 days and by approximately 20% from 10 days to 1 month after stroke. Healthcare providers should be aware of the increased prevalence of sarcopenia during the acute phase in stroke patients.
Editorial Material
Emergency Medicine
Keisuke Maeda, Yuji Okazaki, Toshihisa Ichiba
ANNALS OF EMERGENCY MEDICINE
(2023)
Article
Clinical Neurology
Daisuke Moriyama, Yoji Kokura, Shinta Nishioka, Keisuke Maeda, Akio Shimizu, Hirotaka Tanaka, Tomoe Watanabe, HIdetaka Wakabayashi
Summary: This study investigated the association between sufficient energy intake and improvement in activities of daily living (ADL) after hospitalization in patients with cervical spinal cord injury (CSCI) undergoing post-acute rehabilitation. Multiple regression analysis showed no association between sufficient energy intake and ADL improvement during hospitalization.
JOURNAL OF SPINAL CORD MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Yuhu Feng, Keisuke Maeda, Takahiro Ogawa, Miki Haseyama
Summary: This article proposes a re-ranking method for content-based image retrieval (CBIR) that utilizes a user's gaze trace as interactive information to predict their inherent attention. By generating image captions based on the gaze trace, the proposed method effectively expresses the relationship between images and gaze information, resulting in more accurate alignment with user preferences or interests.
APPLIED SCIENCES-BASEL
(2023)
Article
Nutrition & Dietetics
Ryosuke Fujii, Yoshitaka Ando, Hiroya Yamada, Yoshiki Tsuboi, Eiji Munetsuna, Mirai Yamazaki, Genki Mizuno, Keisuke Maeda, Koji Ohashi, Hiroaki Ishikawa, Mami Watanabe, Nahomi Imaeda, Chiho Goto, Kenji Wakai, Shuji Hashimoto, Koji Suzuki
Summary: This study investigated the impact of methylation quantitative loci (mQTL) on the relationship between dietary nutrient intake and leukocyte DNA methylation levels, using ABCA1 and estimated fatty acid intake as an example. The results showed that higher dietary n-3 PUFA intake was associated with lower ABCA1 DNA methylation levels, even after controlling for individual genetic background.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Geriatrics & Gerontology
Kohei Takahashi, Hidetaka Wakabayashi, Keisuke Maeda, Takako Nagai, Ryo Momosaki
Summary: This study found that in patients with vertebral compression fractures, being underweight is associated with lower Barthel Index scores, longer hospital stays, and increased readmissions within 30 days of discharge.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Ayano Nagano, Masami Onaka, Keisuke Maeda, Junko Ueshima, Akio Shimizu, Yuria Ishida, Shinsuke Nagami, Shuzo Miyahara, Keiji Nishihara, Akiyuki Yasuda, Shosuke Satake, Naoharu Mori
Summary: This study aimed to investigate the prevalence, progression, and distinct attributes of sarcopenic dysphagia (SD) in geriatric medicine. The study found that SD was common among older patients and those with SD showed a better recovery rate compared to other types of dysphagia. Patients with SD had compromised nutritional profiles, diminished energy and protein consumption, and extended fasting durations. Thus, an integrated approach in geriatric medicine is crucial for addressing SD.
Review
Nutrition & Dietetics
Keisuke Maeda, Motoomi Nagasaka, Ayano Nagano, Shinsuke Nagami, Kakeru Hashimoto, Masaki Kamiya, Yuto Masuda, Kenichi Ozaki, Koki Kawamura
Summary: Dysphagia, a syndrome of abnormal eating function associated with malnutrition, has traditionally been difficult to assess without invasive and expensive methods. However, recent advancements in ultrasound technology have made it possible to noninvasively evaluate swallowing-related muscles and propose a protocol for diagnosing sarcopenic dysphagia in elderly patients.
Review
Geriatrics & Gerontology
Hidenori Arai, Keisuke Maeda, Hidetaka Wakabayashi, Tateaki Naito, Masaaki Konishi, Prasert Assantachai, Wai Tung Auyeung, Chalobol Chalermsri, Wei Chen, Justin Chew, Ming-Yueh Chou, Chih-Cheng Hsu, Allyn Hum, In Gyu Hwang, Toshimi Kaido, Lin Kang, Shahrul Bahyah Kamaruzzaman, Miji Kim, Jenny Shun Wah Lee, Wei-Ju Lee, Chih-Kuang Liang, Wee Shiong Lim, Jae-Young Lim, Yen Peng Lim, Raymond See-Kit Lo, Terence Ong, Wen-Harn Pan, Li-Ning Peng, Pornpoj Pramyothin, Nurul Huda Razalli, Masakazu Saitoh, Suzana Shahar, Han Ping Shi, Heng-Hsin Tung, Yasuhito Uezono, Stephan von Haehling, Chang Won Won, Jean Woo, Liang-Kung Chen
Summary: Chronic diseases can cause metabolic disorders and lead to cachexia, a condition that has major clinical consequences. Existing diagnostic criteria for cachexia may not apply to Asians, so the Asian Working Group for Cachexia was initiated to develop a consensus specifically for Asian populations. The AWGC consensus provides a comprehensive definition and user-friendly diagnostic criteria for cachexia in Asia, and it is expected to drive research and improve the management of cachexia in the future.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Chemistry, Multidisciplinary
Koshi Watanabe, Keisuke Maeda, Takahiro Ogawa, Miki Haseyama
Summary: Dimensionality reduction is crucial for interpreting and visualizing high-dimensional data. However, previous methods tend to overestimate local structure and overlook global preservation. In this study, we propose a Gaussian process latent variable model (GP-LVM) for data visualization, which effectively preserves global structure. To address the limitations of GP-LVM in terms of local structure preservation and expressive kernel functions, we introduce regularization and an expressive kernel function. The results demonstrate that our approach captures both global and local structures in low-dimensional representations, enhancing the reliability and visibility of embeddings. We conduct qualitative and quantitative experiments, comparing our method with baselines and state-of-the-art techniques on image and text datasets.
APPLIED SCIENCES-BASEL
(2023)
Article
Nutrition & Dietetics
Yuria Ishida, Keisuke Maeda, Kenta Murotani, Akio Shimizu, Junko Ueshima, Ayano Nagano, Norihiro Sonoi, Tatsuro Inoue, Naoharu Mori
Summary: This study aimed to investigate the association between body mass index (BMI) and rate of weight change with adverse outcomes in Asian patients with chronic kidney disease. A retrospective cohort study was conducted using administrative claims data from April 2014 to June 2022. The results showed that low BMI and increasing rate of weight change were associated with higher hazard ratios (HRs).
