SUMOylated IL-33 in the nucleus stabilizes the transcription factor IRF1 in hepatocellular carcinoma cells to promote immune escape

The SUMOylation inhibitor subasumstat potentiates rituximab activity by IFN1-dependent macrophage and NK cell stimulation

(2022) Akito Nakamura et al.   BLOOD

Emerging immunotherapy for HCC: A guide for hepatologists

(2022) Friedrich Foerster et al.   HEPATOLOGY

Deubiquitinase-targeting chimeras for targeted protein stabilization

(2022) Nathaniel J. Henning et al.   Nature Chemical Biology

Nuclear IL‐33/SMAD signaling axis promotes cancer development in chronic inflammation

(2021) Jong Ho Park et al.   EMBO JOURNAL

The Antiviral Enzyme, Viperin, Activates Protein Ubiquitination by the E3 Ubiquitin Ligase, TRAF6

(2021) Ayesha M. Patel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interleukin 33 mediates hepatocyte autophagy and innate immune response in the early phase of acetaminophen-induced acute liver injury

(2021) Zengbin Wang et al.   TOXICOLOGY

A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models

(2021) Eric S. Lightcap et al.   Science Translational Medicine

RANBP2 Activates O-GlcNAcylation through Inducing CEBPα-Dependent OGA Downregulation to Promote Hepatocellular Carcinoma Malignant Phenotypes

(2021) Xiaoming Liu et al.   Cancers

The interleukin-1 cytokine family members: Role in cancer pathogenesis and potential therapeutic applications in cancer immunotherapy

(2021) Bart Boersma et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The Nuclear Function of IL-33 in Desensitization to DNA Damaging Agent and Change of Glioma Nuclear Structure

(2021) Yu-Han Chung et al.   Frontiers in Cellular Neuroscience

SUMO pathway inhibition targets an aggressive pancreatic cancer subtype

(2020) Alexander Biederstädt et al.   GUT

SIRT1 regulates N 6 ‐methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2‐dependent FTO SUMOylation

(2020) Xiaoming Liu et al.   HEPATOLOGY

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

(2020) Richard S. Finn et al.   NEW ENGLAND JOURNAL OF MEDICINE

TIMER2.0 for analysis of tumor-infiltrating immune cells

(2020) Taiwen Li et al.   NUCLEIC ACIDS RESEARCH

Targeting post-translational modification of transcription factors as cancer therapy

(2020) Meijia Qian et al.   DRUG DISCOVERY TODAY

Exogenous interleukin-33 promotes hepatocellular carcinoma growth by remodelling the tumour microenvironment

(2020) Wenxiu Wang et al.   Journal of Translational Medicine

Tumor-Associated Macrophages in Tumor Immunity

(2020) Yueyun Pan et al.   Frontiers in Immunology

Proof-of-concept clinical trial of etokimab shows a key role for IL-33 in atopic dermatitis pathogenesis

(2019) Yi-Ling Chen et al.   Science Translational Medicine

Role of the IL-33/ST2L axis in colorectal cancer progression

(2018) Miho Akimoto et al.   CELLULAR IMMUNOLOGY

The Role of IL-33/ST2 Pathway in Tumorigenesis

(2018) Kristen Larsen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SUMO-Mediated Regulation of Nuclear Functions and Signaling Processes

(2018) Xiaolan Zhao   MOLECULAR CELL

IL-33 Released in the Liver Inhibits Tumor Growth via Promotion of CD4+ and CD8+ T Cell Responses in Hepatocellular Carcinoma

(2018) Ziqi Jin et al.   JOURNAL OF IMMUNOLOGY

Endothelial IL-33 Expression Is Augmented by Adenoviral Activation of the DNA Damage Machinery

(2017) Tor Espen Stav-Noraas et al.   JOURNAL OF IMMUNOLOGY

ConTra v3: a tool to identify transcription factor binding sites across species, update 2017

(2017) Łukasz Kreft et al.   NUCLEIC ACIDS RESEARCH

IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks

(2017) Bryan Serrels et al.   Science Signaling

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks

(2017) Bryan Serrels et al.   Science Signaling

Analyzing and interpreting genome data at the network level with ConsensusPathDB

(2016) Ralf Herwig et al.   Nature Protocols

Role of IL-33 expression in oncogenesis and development of human hepatocellular carcinoma

(2016) YAN YANG et al.   Oncology Letters

The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes

(2016) Tobias Ritterhoff et al.   Nature Communications

Tumor necrosis factor receptor- associated factor 6 (TRAF6) regulation of development, function, and homeostasis of the immune system

(2015) Matthew C. Walsh et al.   IMMUNOLOGICAL REVIEWS

RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination

(2013) Meredith B. Metzger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Nuclear IL-33 is a transcriptional regulator of NF-κB p65 and induces endothelial cell activation

(2012) Yeon-Sook Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IL-33/ST2 axis in inflammation and immunopathology

(2012) Marija Milovanovic et al.   IMMUNOLOGIC RESEARCH

The Dual Function Cytokine IL-33 Interacts with the Transcription Factor NF- B To Dampen NF- B-Stimulated Gene Transcription

(2011) S. Ali et al.   JOURNAL OF IMMUNOLOGY

A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis

(2011) J. D. Kessler et al.   SCIENCE

The Nucleoporin Nup358/RanBP2 Promotes Nuclear Import in a Cargo- and Transport Receptor-Specific Manner

(2011) Sarah Wälde et al.   TRAFFIC

SUMO Regulates the Assembly and Function of a Cytoplasmic Intermediate Filament Protein in C. elegans

(2009) Rachel Kaminsky et al.   DEVELOPMENTAL CELL