Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs

The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression

(2022) Anne E. Geller et al.   Nature Communications

Aerosol delivery, but not intramuscular injection, of adenovirus-vectored tuberculosis vaccine induces respiratory-mucosal immunity in humans

(2022) Mangalakumari Jeyanathan et al.   JCI Insight

Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis

(2022) Mangalakumari Jeyanathan et al.   NATURE IMMUNOLOGY

Topological analysis of hepatocellular carcinoma tumour microenvironment based on imaging mass cytometry reveals cellular neighbourhood regulated reversely by macrophages with different ontogeny

(2021) Jianpeng Sheng et al.   GUT

Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells

(2021) María Casanova-Acebes et al.   NATURE

Immunoregulatory Monocyte Subset Promotes Metastasis Associated With Therapeutic Intervention for Primary Tumor

(2021) Takumi Shibuya et al.   Frontiers in Immunology

Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification

(2021) Andrew M. Leader et al.   CANCER CELL

Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

(2020) Yi Zhou et al.   IMMUNITY

Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection

(2020) Helena Aegerter et al.   NATURE IMMUNOLOGY

Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses

(2020) Jesse M. Jaynes et al.   Science Translational Medicine

Trained Immunity for Personalized Cancer Immunotherapy: Current Knowledge and Future Opportunities

(2020) Joana R. Lérias et al.   Frontiers in Microbiology

PIRs mediate innate myeloid cell memory to nonself MHC molecules

(2020) Hehua Dai et al.   SCIENCE

Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non-Small-Cell Lung Carcinoma

(2020) Xiang Zheng et al.   CANCER RESEARCH

Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly

(2020) Evangelos J. Giamarellos-Bourboulis et al.   CELL

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

(2020) Maziar Divangahi et al.   NATURE IMMUNOLOGY

Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47−mediated ‘don’t-eat-me’ signal

(2019) Mingen Liu et al.   NATURE IMMUNOLOGY

Induction of memory-like dendritic cell responses in vivo

(2019) Camaron R. Hole et al.   Nature Communications

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

(2018) Ioannis Mitroulis et al.   CELL

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

(2018) Eva Kaufmann et al.   CELL

Effects of Influenza on Alveolar Macrophage Viability Are Dependent on Mouse Genetic Strain

(2018) Danielle Califano et al.   JOURNAL OF IMMUNOLOGY

Trained Immunity and Local Innate Immune Memory in the Lung

(2018) Mihai G. Netea et al.   CELL

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity

(2018) Yushi Yao et al.   CELL

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

(2017) Yu Zhu et al.   IMMUNITY

Hypothesis: stimulation of trained immunity as adjunctive immunotherapy in cancer

(2017) Mihai G. Netea et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lung cancer: current therapies and new targeted treatments

(2017) Fred R Hirsch et al.   LANCET

Localized CD47 blockade enhances immunotherapy for murine melanoma

(2017) Jessica R. Ingram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualization of immediate immune responses to pioneer metastatic cells in the lung

(2016) Mark B. Headley et al.   NATURE

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Pulmonary Alveolar Macrophages Contribute to the Premetastatic Niche by Suppressing Antitumor T Cell Responses in the Lungs

(2015) Sharad K. Sharma et al.   JOURNAL OF IMMUNOLOGY

The development and function of lung-resident macrophages and dendritic cells

(2015) Manfred Kopf et al.   NATURE IMMUNOLOGY

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Negative Regulation of Lung Inflammation and Immunopathology by TNF-α during Acute Influenza Infection

(2011) Daniela Damjanovic et al.   AMERICAN JOURNAL OF PATHOLOGY

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

Transiently Entrapped Circulating Tumor Cells Interact with Neutrophils to Facilitate Lung Metastasis Development

(2010) S. J. Huh et al.   CANCER RESEARCH

COMPARISON OF CONDITIONING REGIMENS FOR ALVEOLAR MACROPHAGE RECONSTITUTION AND INNATE IMMUNE FUNCTION POST BONE MARROW TRANSPLANT

(2008) Leah L. N. Hubbard et al.   EXPERIMENTAL LUNG RESEARCH