Structural basis of paralog-specific KDM2A/B nucleosome recognition

DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding

(2022) Cathy J. Spangler et al.   Cell Reports

Time Resolved‐Fluorescence Resonance Energy Transfer platform for quantitative nucleosome binding and footprinting

(2022) Nathaniel A. Wesley et al.   PROTEIN SCIENCE

Oncohistone mutations enhance chromatin remodeling and alter cell fates

(2021) John D. Bagert et al.   Nature Chemical Biology

CryoDRGN: reconstruction of heterogeneous cryo-EM structures using neural networks

(2021) Ellen D. Zhong et al.   NATURE METHODS

Lysine Demethylases: Promising Drug Targets in Melanoma and Other Cancers

(2021) Gaya Punnia-Moorthy et al.   Frontiers in Genetics

Principles of nucleosome recognition by chromatin factors and enzymes

(2021) Robert K. McGinty et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Estimation of high-order aberrations and anisotropic magnification from cryo-EM data sets in RELION-3.1

(2020) Jasenko Zivanov et al.   IUCrJ

Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding

(2020) Aleksandra Skrajna et al.   NUCLEIC ACIDS RESEARCH

Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases

(2020) Wanqiu Li et al.   NATURE

Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase

(2019) Cathy J. Anderson et al.   Cell Reports

The expanding landscape of ‘oncohistone’ mutations in human cancers

(2019) Benjamin A. Nacev et al.   NATURE

Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation

(2019) Bas J. G. E. Pieters et al.   BIOCONJUGATE CHEMISTRY

A Mutation in Histone H2B Represents a New Class of Oncogenic Driver

(2019) Richard L Bennett et al.   Cancer Discovery

Nucleosome and ubiquitin position Set2 to methylate H3K36

(2019) Silvija Bilokapic et al.   Nature Communications

KDM2A/B lysine demethylases and their alternative isoforms in development and disease

(2018) Tomáš Vacík et al.   Nucleus

New tools for the analysis and validation of cryo-EM maps and atomic models

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes

(2016) Florian Weissmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenic Mechanisms of Histone H3 Mutations

(2016) Daniel N. Weinberg et al.   Cold Spring Harbor Perspectives in Medicine

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Extranucleosomal DNA enhances the activity of the LSD1/CoREST histone demethylase complex

(2015) Sang-Ah Kim et al.   NUCLEIC ACIDS RESEARCH

A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36

(2014) Zhongjun Cheng et al.   GENES & DEVELOPMENT

Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity

(2013) Takayoshi Suzuki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fbxl10/Kdm2b Recruits Polycomb Repressive Complex 1 to CpG Islands and Regulates H2A Ubiquitylation

(2013) Xudong Wu et al.   MOLECULAR CELL

Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact

(2012) Joshua C. Black et al.   MOLECULAR CELL

PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes

(2012) Zhonghua Gao et al.   MOLECULAR CELL

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

(2012) Anca M Farcas et al.   eLife

An introduction to data reduction: space-group determination, scaling and intensity statistics

(2011) Philip R. Evans   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state

(2011) David Frescas et al.   CELL CYCLE

A Selective Inhibitor and Probe of the Cellular Functions of Jumonji C Domain-Containing Histone Demethylases

(2011) Xuelai Luo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recognition of CpG Island Chromatin by KDM2A Requires Direct and Specific Interaction with Linker DNA

(2011) J. C. Zhou et al.   MOLECULAR AND CELLULAR BIOLOGY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation

(2010) Till Bartke et al.   CELL

Design, Synthesis, Enzyme-Inhibitory Activity, and Effect on Human Cancer Cells of a Novel Series of Jumonji Domain-Containing Protein 2 Histone Demethylase Inhibitors

(2010) Shohei Hamada et al.   JOURNAL OF MEDICINAL CHEMISTRY

CpG Islands Recruit a Histone H3 Lysine 36 Demethylase

(2010) Neil P. Blackledge et al.   MOLECULAR CELL

Structure of RCC1 chromatin factor bound to the nucleosome core particle

(2010) Ravindra D. Makde et al.   NATURE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing

(2008) A. Lagarou et al.   GENES & DEVELOPMENT