DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding

ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism

(2021) Jie Li et al.   Nature Communications

Phase separation drives aberrant chromatin looping and cancer development

(2021) Jeong Hyun Ahn et al.   NATURE

Principles of nucleosome recognition by chromatin factors and enzymes

(2021) Robert K. McGinty et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models

(2021) Xufen Yu et al.   Science Translational Medicine

Single-molecule FRET method to investigate the dynamics of transcription elongation through the nucleosome by RNA polymerase II

(2019) Jaehyoun Lee et al.   METHODS

Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase

(2019) Cathy J. Anderson et al.   Cell Reports

Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase

(2019) Seongmin Jang et al.   GENES & DEVELOPMENT

Structural basis of the crosstalk between histone H2B monoubiquitination and H3 lysine 79 methylation on nucleosome

(2019) Tonghui Yao et al.   CELL RESEARCH

Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L

(2019) Evan J. Worden et al.   CELL

Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination

(2019) Marco Igor Valencia-Sánchez et al.   MOLECULAR CELL

LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia

(2018) Yusuke Tarumoto et al.   MOLECULAR CELL

Mechanisms of Pinometostat (EPZ-5676) Treatment–Emergent Resistance in MLL -Rearranged Leukemia

(2017) Carly T. Campbell et al.   MOLECULAR CANCER THERAPEUTICS

ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia

(2017) Liling Wan et al.   NATURE

Single-Molecule Studies of the Linker Histone H1 Binding to DNA and the Nucleosome

(2016) Hongjun Yue et al.   BIOCHEMISTRY

Recognition of the nucleosome by chromatin factors and enzymes

(2016) Robert K McGinty et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The molecular mechanics of mixed lineage leukemia

(2016) R K Slany   ONCOGENE

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia

(2015) Chun-Wei Chen et al.   NATURE MEDICINE

Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia

(2014) B. Xu et al.   BLOOD

Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome

(2014) Robert K. McGinty et al.   NATURE

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia

(2013) E. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

(2011) Scott R. Daigle et al.   CANCER CELL

RCC1 Uses a Conformationally Diverse Loop Region to Interact with the Nucleosome: A Model for the RCC1–Nucleosome Complex

(2010) Joseph R. England et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of RCC1 chromatin factor bound to the nucleosome core particle

(2010) Ravindra D. Makde et al.   NATURE

Extracting Kinetics Information from Single-Molecule Fluorescence Resonance Energy Transfer Data Using Hidden Markov Models

(2009) Tae-Hee Lee   JOURNAL OF PHYSICAL CHEMISTRY B

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

(2008) Robert K. McGinty et al.   NATURE

The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure

(2008) Brendan Jones et al.   PLoS Genetics