Computational insights into mRNA and protein dynamics underlying synaptic plasticity rules

Protein lifetimes in aged brains reveal a proteostatic adaptation linking physiological aging to neurodegeneration

(2022) Verena Kluever et al.   Science Advances

Heterosynaptic cross-talk of pre- and postsynaptic strengths along segments of dendrites

(2021) Rudi Tong et al.   Cell Reports

Paradoxical relationships between active transport and global protein distributions in neurons

(2021) Adriano Bellotti et al.   BIOPHYSICAL JOURNAL

Differential regulation of local mRNA dynamics and translation following long-term potentiation and depression

(2021) Paul G. Donlin-Asp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines

(2021) Martin S. Helm et al.   NATURE NEUROSCIENCE

Emergence of local and global synaptic organization on cortical dendrites

(2021) Jan H. Kirchner et al.   Nature Communications

The prevalence and specificity of local protein synthesis during neuronal synaptic plasticity

(2021) Chao Sun et al.   Science Advances

Synaptic plasticity depends on the fine-scale input pattern in thin dendrites of CA1 pyramidal neurons

(2020) Ádám Magó et al.   JOURNAL OF NEUROSCIENCE

Heterosynaptic Plasticity Determines the Set Point for Cortical Excitatory-Inhibitory Balance

(2020) Rachel E. Field et al.   NEURON

Linking glutamate receptor movements and synapse function

(2020) Laurent Groc et al.   SCIENCE

A spike-timing-dependent plasticity rule for dendritic spines

(2020) Sabrina Tazerart et al.   Nature Communications

Mechanism underlying hippocampal long-term potentiation and depression based on competition between endocytosis and exocytosis of AMPA receptors

(2020) Tomonari Sumi et al.   Scientific Reports

How mRNA Localization and Protein Synthesis Sites Influence Dendritic Protein Distribution and Dynamics

(2019) Yombe Fonkeu et al.   NEURON

Unifying Long-Term Plasticity Rules for Excitatory Synapses by Modeling Dendrites of Cortical Pyramidal Neurons

(2019) Christian Ebner et al.   Cell Reports

Synaptic Clustering and Memory Formation

(2019) George Kastellakis et al.   Frontiers in Molecular Neuroscience

Alternative 3′ UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal Compartments

(2018) Georgi Tushev et al.   NEURON

Locally coordinated synaptic plasticity of visual cortex neurons in vivo

(2018) Sami El-Boustani et al.   SCIENCE

Neuronal messenger ribonucleoprotein transport follows an aging Lévy walk

(2018) Minho S. Song et al.   Nature Communications

AMPA receptor trafficking and its role in heterosynaptic plasticity

(2018) G. Antunes et al.   Scientific Reports

Neuronal Activity and Intracellular Calcium Levels Regulate Intracellular Transport of Newly Synthesized AMPAR

(2018) Emilie Hangen et al.   Cell Reports

A BDNF-Mediated Push-Pull Plasticity Mechanism for Synaptic Clustering

(2018) Dragos Niculescu et al.   Cell Reports

Competition for synaptic building blocks shapes synaptic plasticity

(2018) Jochen Triesch et al.   eLife

Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model

(2018) Daniel B Dorman et al.   eLife

Metabolic labeling and recovery of nascent RNA to accurately quantify mRNA stability

(2017) Joseph Russo et al.   METHODS

CaMKII Autophosphorylation Is Necessary for Optimal Integration of Ca 2+ Signals during LTP Induction, but Not Maintenance

(2017) Jui-Yun Chang et al.   NEURON

Protein Crowding within the Postsynaptic Density Can Impede the Escape of Membrane Proteins

(2016) T. P. Li et al.   JOURNAL OF NEUROSCIENCE

Imaging Single-mRNA Localization and Translation in Live Neurons

(2016) Byung Hun Lee et al.   MOLECULES AND CELLS

Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity

(2016) Nathan G. Hedrick et al.   NATURE

Visualization of newly synthesized neuronal RNA in vitro and in vivo using click-chemistry

(2016) Güney Akbalik et al.   RNA Biology

Location-dependent synaptic plasticity rules by dendritic spine cooperativity

(2016) Jens P. Weber et al.   Nature Communications

Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites

(2016) George Kastellakis et al.   Cell Reports

Dendritic trafficking faces physiologically critical speed-precision tradeoffs

(2016) Alex H Williams et al.   eLife

Proteomics of the Synapse – A Quantitative Approach to Neuronal Plasticity

(2015) Daniela C. Dieterich et al.   MOLECULAR & CELLULAR PROTEOMICS

Direct visualization of newly synthesized target proteins in situ

(2015) Susanne tom Dieck et al.   NATURE METHODS

Spontaneous Activity Drives Local Synaptic Plasticity In Vivo

(2015) Johan Winnubst et al.   NEURON

Diverse synaptic plasticity mechanisms orchestrated to form and retrieve memories in spiking neural networks

(2015) Friedemann Zenke et al.   Nature Communications

Heterosynaptic Structural Plasticity on Local Dendritic Segments of Hippocampal CA1 Neurons

(2015) Won Chan Oh et al.   Cell Reports

Bidirectional cargo transport: moving beyond tug of war

(2014) William O. Hancock   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selective Memory Generalization by Spatial Patterning of Protein Synthesis

(2014) Cian O’Donnell et al.   NEURON

The Dynamic Synapse

(2013) Daniel Choquet et al.   NEURON

Synaptic competition in structural plasticity and cognitive function

(2013) Y. Ramiro-Cortes et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Stochastic models of intracellular transport

(2013) Paul C. Bressloff et al.   REVIEWS OF MODERN PHYSICS

Synaptic Plasticity in Neural Networks Needs Homeostasis with a Fast Rate Detector

(2013) Friedemann Zenke et al.   PLoS Computational Biology

Translocation of CaMKII to dendritic microtubules supports the plasticity of local synapses

(2012) Mado Lemieux et al.   JOURNAL OF CELL BIOLOGY

The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging

(2012) Iván J. Cajigas et al.   NEURON

Unified quantitative model of AMPA receptor trafficking at synapses

(2012) K. Czondor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Constraints on Synaptic Tagging and Maintenance of Long-Term Potentiation: A Predictive Model

(2012) Paul Smolen et al.   PLoS Computational Biology

Mechanisms of dendritic mRNA transport and its role in synaptic tagging

(2011) Michael Doyle et al.   EMBO JOURNAL

Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells

(2011) Michal Rabani et al.   NATURE BIOTECHNOLOGY

The Dendritic Branch Is the Preferred Integrative Unit for Protein Synthesis-Dependent LTP

(2011) Arvind Govindarajan et al.   NEURON

Making memories last: the synaptic tagging and capture hypothesis

(2010) Roger L. Redondo et al.   NATURE REVIEWS NEUROSCIENCE

Spike-Time-Dependent Plasticity and Heterosynaptic Competition Organize Networks to Produce Long Scale-Free Sequences of Neural Activity

(2010) Ila R. Fiete et al.   NEURON

AMPA receptors are exocytosed in stimulated spines and adjacent dendrites in a Ras-ERK-dependent manner during long-term potentiation

(2010) M. A. Patterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Domains within PSD-95 Mediate Synaptic Incorporation, Stabilization, and Activity-Dependent Trafficking

(2009) J. F. Sturgill et al.   JOURNAL OF NEUROSCIENCE

Activation of CaMKII in single dendritic spines during long-term potentiation

(2009) Seok-Jin R. Lee et al.   NATURE

Directed intermittent search for hidden targets

(2009) Paul Bressloff et al.   NEW JOURNAL OF PHYSICS

State Based Model of Long-Term Potentiation and Synaptic Tagging and Capture

(2009) Adam B. Barrett et al.   PLoS Computational Biology

Rapid Translation of Arc/Arg3.1 Selectively Mediates mGluR-Dependent LTD through Persistent Increases in AMPAR Endocytosis Rate

(2008) Maggie W. Waung et al.   NEURON

Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors

(2008) M. J. I. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tag-Trigger-Consolidation: A Model of Early and Late Long-Term-Potentiation and Depression

(2008) Claudia Clopath et al.   PLoS Computational Biology