Zinc finger protein 24-dependent transcription factor SOX9 up-regulation protects tubular epithelial cells during acute kidney injury

Experimental models of acute kidney injury for translational research

(2022) Neil A. Hukriede et al.   Nature Reviews Nephrology

Kidney repair and regeneration: perspectives of the NIDDK (Re)Building a Kidney consortium

(2022) Bilal A. Naved et al.   KIDNEY INTERNATIONAL

SOX9 is required for kidney fibrosis and activates NAV3 to drive renal myofibroblast function

(2021) Sayyid Raza et al.   Science Signaling

Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors

(2021) Jilai Zhao et al.   Nature Communications

Rapamycin Alternatively Modifies Mitochondrial Dynamics in Dendritic Cells to Reduce Kidney Ischemic Reperfusion Injury

(2021) Maria Namwanje et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Potential Therapeutic Targets for Cisplatin-Induced Kidney Injury: Lessons from Other Models of AKI and Fibrosis

(2021) Sophia M. Sears et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Kidney toxicity of the BRAF-kinase inhibitor vemurafenib is driven by off-target ferrochelatase inhibition.

(2021) Yuntao Bai et al.   KIDNEY INTERNATIONAL

Single-nuclear transcriptomics reveals diversity of proximal tubule cell states in a dynamic response to acute kidney injury

(2021) Louisa M. S. Gerhardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acute kidney injury

(2021) John A. Kellum et al.   Nature Reviews Disease Primers

Myeloid cyclooxygenase-2/prostaglandin E2/E-type prostanoid receptor 4 promotes transcription factor MafB-dependent inflammatory resolution in acute kidney injury

(2021) Yu Pan et al.   KIDNEY INTERNATIONAL

Gilteritinib-induced upregulation of S100A9 is mediated through BCL6 in acute myeloid leukemia

(2021) Megan E. Zavorka Thomas et al.   Blood Advances

A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury

(2020) Ji Young Kim et al.   Nature Communications

Ribociclib mitigates cisplatin-associated kidney injury through retinoblastoma-1 dependent mechanisms

(2020) Ji Young Kim et al.   BIOCHEMICAL PHARMACOLOGY

A prospective cohort study that examined acute kidney injury and kidney outcomes, cardiovascular events and death informs on long-term clinical outcomes.

(2020) T. Alp Ikizler et al.   KIDNEY INTERNATIONAL

Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury

(2020) Yuhei Kirita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells

(2020) Ji Young Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular Senescence in the Kidney

(2019) Marie-Helena Docherty et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cellular and molecular pathways of renal repair after acute kidney injury

(2018) Sanjeev Kumar   KIDNEY INTERNATIONAL

Phosphorylation State of ZFP24 Controls Oligodendrocyte Differentiation

(2018) Benayahu Elbaz et al.   Cell Reports

Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia

(2017) Jolieke G. van Oosterwijk et al.   JOURNAL OF CLINICAL INVESTIGATION

SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions

(2017) Wei Sun et al.   JOURNAL OF NEUROSCIENCE

Neuroimmune Interactions in Inflammation and Acute Kidney Injury

(2017) Tsuyoshi Inoue et al.   Frontiers in Immunology

Acute Kidney Injury

(2016) Anna Zuk et al.   Annual Review of Medicine

A phosphotyrosine switch regulates organic cation transporters

(2016) Jason A. Sprowl et al.   Nature Communications

Sox9-Positive Progenitor Cells Play a Key Role in Renal Tubule Epithelial Regeneration in Mice

(2016) Hyun Mi Kang et al.   Cell Reports

Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD

(2015) David A. Ferenbach et al.   Nature Reviews Nephrology

Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions

(2015) Navjotsingh Pabla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sox9 Activation Highlights a Cellular Pathway of Renal Repair in the Acutely Injured Mammalian Kidney

(2015) Sanjeev Kumar et al.   Cell Reports

SOX9: a stem cell transcriptional regulator of secreted niche signaling factors

(2014) M. Kadaja et al.   GENES & DEVELOPMENT

Regulated Cell Death in AKI

(2014) A. Linkermann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes

(2014) Lakhmir S. Chawla et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sox proteins: regulators of cell fate specification and differentiation

(2013) Y. Kamachi et al.   DEVELOPMENT

Renal oxygenation and haemodynamics in acute kidney injury and chronic kidney disease

(2012) Prabhleen Singh et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Sox9 function in craniofacial development and disease

(2011) Young-Hoon Lee et al.   GENESIS

Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer

(2011) Navjotsingh Pabla et al.   JOURNAL OF CLINICAL INVESTIGATION

Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints

(2011) N. Pabla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the role of SOX9 in acquired diseases: lessons from development

(2011) James Pritchett et al.   TRENDS IN MOLECULAR MEDICINE

ZFP191 is required by oligodendrocytes for CNS myelination

(2010) S. Y. B. Howng et al.   GENES & DEVELOPMENT

Immune Mechanisms and Novel Pharmacological Therapies of Acute Kidney Injury

(2009) Amandeep Bajwa et al.   CURRENT DRUG TARGETS