Clonal Hematopoiesis of Indeterminate Potential Predicts Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease

A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic datasets

(2023) Caitlyn Vlasschaert et al.   BLOOD

Interleukin-6 Receptor Polymorphism Attenuates Clonal Hematopoiesis-Mediated Coronary Artery Disease Risk Among 451 180 Individuals in the UK Biobank

(2023) Caitlyn Vlasschaert et al.   CIRCULATION

TET2-Driven Clonal Hematopoiesis and Response to Canakinumab

(2022) Eric C. Svensson et al.   JAMA Cardiology

Prevalence and prognostic significance of DNMT3A- and TET2- clonal haematopoiesis-driver mutations in patients presenting with ST-segment elevation myocardial infarction

(2022) Shengfang Wang et al.   EBioMedicine

Clonal haematopoiesis is associated with higher mortality in patients with cardiogenic shock

(2022) Fernando L. Scolari et al.   EUROPEAN JOURNAL OF HEART FAILURE

The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms

(2022) Joseph D. Khoury et al.   LEUKEMIA

Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis

(2022) Siddhartha P. Kar et al.   NATURE GENETICS

Impact of Clonal Hematopoiesis in Patients With Cardiogenic Shock Complicating Acute Myocardial Infarction

(2022) Matthias Böhme et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genomic Aging, Clonal Hematopoiesis, and Cardiovascular Disease

(2022) Pradeep Natarajan   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Associations of clonal haematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke

(2022) Christopher Maximilian Arends et al.   BLOOD

Common and rare variant associations with clonal haematopoiesis phenotypes

(2022) Michael D. Kessler et al.   NATURE

Risk factors for clonal hematopoiesis of indeterminate potential and mosaic chromosomal alterations

(2022) Yasminka A. Jakubek et al.   Translational Research

Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis

(2021) Alexander Heyde et al.   CELL

Clonal Hematopoiesis and Risk of Progression of Heart Failure With Reduced Left Ventricular Ejection Fraction

(2021) Domingo A. Pascual-Figal et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis

(2021) Trevor P. Fidler et al.   NATURE

Exome sequencing and analysis of 454,787 UK Biobank participants

(2021) Joshua D. Backman et al.   NATURE

Clonal Hematopoiesis Is Associated With Higher Risk of Stroke

(2021) Romit Bhattacharya et al.   STROKE

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

(2020) Alexander G. Bick et al.   NATURE

Clonal haematopoiesis in chronic ischaemic heart failure: prognostic role of clone size for DNMT3A- and TET2-driver gene mutations

(2020) Birgit Assmus et al.   EUROPEAN HEART JOURNAL

Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019

(2020) Gregory A. Roth et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women

(2020) Michael C. Honigberg et al.   CIRCULATION

Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling

(2019) Daniel A. Pollyea et al.   HAEMATOLOGICA

Clonal Hematopoiesis

(2019) Peter Libby et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Clonal haematopoiesis in patients with degenerative aortic valve stenosis undergoing transcatheter aortic valve implantation

(2019) Silvia Mas-Peiro et al.   EUROPEAN HEART JOURNAL

Genetic IL-6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis

(2019) Alexander G. Bick et al.   CIRCULATION

Clonal hematopoiesis in human aging and disease

(2019) Siddhartha Jaiswal et al.   SCIENCE

CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular DiseaseNovelty and Significance

(2018) Soichi Sano et al.   CIRCULATION RESEARCH

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

(2018) Soichi Sano et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

(2018) Stanley Chun-Wei Lee et al.   CANCER CELL

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure

(2018) Lena Dorsheimer et al.   JAMA Cardiology

Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

(2017) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

(2017) José J. Fuster et al.   SCIENCE

A Systematic Examination of the 2013 ACC/AHA Pooled Cohort Risk Assessment Tool for Atherosclerotic Cardiovascular Disease

(2014) Kunal N. Karmali et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

(2013) Kristian Cibulskis et al.   NATURE BIOTECHNOLOGY

The Intersection Between Aging and Cardiovascular Disease

(2012) Brian J. North et al.   CIRCULATION RESEARCH