Article
Toxicology
John C. Achenbach, Joseph P. M. Hui, Fabrice Berrue, Cindy Woodland, Lee D. Ellis
Summary: This study evaluated the toxicokinetic profile of 5 known toxicants and 3 phenolic compounds in zebrafish larvae and found that these compounds were actively metabolized and excreted in addition to bioaccumulation effects. Comparisons revealed diverse patterns of uptake and metabolism, which partially explained the differences in their concentration-response patterns. The findings emphasize the need for assessing the stability and toxicokinetic profile of chemicals tested using zebrafish larval toxicity assays.
TOXICOLOGICAL SCIENCES
(2022)
Review
Toxicology
Nuno G. Oliveira, Daniela L. Ramos, Ricardo Jorge Dinis-Oliveira
Summary: Areca nut is consumed by over 600 million individuals and classified as carcinogenic to humans, particularly in South Asia, East Africa, and tropical Pacific regions. Arecoline is the principal active compound of Areca nut and has been systematically studied in several in vitro and in vivo genotoxicity endpoints. The complexity of the chemicals involved in Areca nut makes it a challenge in genetic toxicology, with both positive and negative genotoxicity findings reported in the literature.
ARCHIVES OF TOXICOLOGY
(2021)
Review
Pharmacology & Pharmacy
Mahmoud A. El-Ghiaty, Ayman O. S. El-Kadi
Summary: Arsenic, a naturally occurring hazardous element, is widely distributed in various chemical forms. Biomethylation, a pathway in which arsenic is progressively methylated, has been considered as a detoxification mechanism. However, the emergence of toxic trivalent species has raised debate about whether arsenic methylation is a detoxifying or bioactivating mechanism. This review provides a comprehensive understanding of arsenic metabolism in relation to various arsenic-related pathologies.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)
Review
Geosciences, Multidisciplinary
Devanita Ghosh, Anwesha Ghosh, Punyasloke Bhadury
Summary: This review discusses the occurrence of arsenic (As) in various aquatic habitats and the direct or indirect effects on different organisms, including bacteria, algae, phytoplankton, zooplankton, and higher trophic levels. Special emphasis is given to finfishes and shellfishes that are commonly consumed by humans. The review also provides an overview of commonly used detection methods for As and highlights the importance of using As metabolites as an indicator of human exposure. Furthermore, the integration of 'omics' approaches and advanced sequencing technologies is emphasized for global monitoring of the human gut microbiome and understanding the effects and consequences of As bioaccumulation.
GEOSCIENCE LETTERS
(2022)
Article
Pharmacology & Pharmacy
Elaina M. Kenyon
Summary: Arsenic poses challenges in PBTK model development and risk analysis, with complex metabolism and sparse information on specific metabolites. PBTK models have been used for exposure and dose-response analysis for arsenic, particularly for multi-route exposures and multiple toxic effects. Refinements to arsenic PBTK models, such as improving methylation biotransformation parameters and estimating interindividual variability, can enhance confidence in risk assessments.
Article
Environmental Sciences
Guoliang Chen, Linping Wang, Mingxing Wang, Tingzhang Hu
Summary: Nodularins (NODs) are a group of cyanotoxins mainly produced by Nodularia spumigena, which may have adverse effects on animal and human health. However, research on NODs is currently limited. More data is needed to study the potential toxicity of NODs and their effects on different species and cells.
MARINE POLLUTION BULLETIN
(2021)
Article
Environmental Sciences
Xupeng Wang, Bing Gong, Erkai He, Willie J. G. M. Peijnenburg, Hao Qiu
Summary: The toxicokinetics of Cd, As, and Zn in earthworms at both whole body and subcellular levels were assessed. The study found concentration-dependent increases in Cd and As in earthworms and subcellular compartments, while Zn maintained a steady-state concentration. These subcellular differences in toxicokinetics supported the observed variations in bioaccumulation patterns and revealed the strategies used by earthworms to handle non-essential and essential elements.
Review
Toxicology
Miroslav Styblo, Abhishek Venkatratnam, Rebecca C. Fry, David J. Thomas
Summary: Methylation of inorganic arsenic is both a detoxification pathway and a mechanism for initiating disease.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Ruiguo Wang, Na Cui, Alexandros Yiannikouris, Yuan Huang, Wenyu Zhao, Xiaoou Su, Gang Lin, Ronghua Zhu, Zhichao Song, Peilong Wang
Summary: This study investigated the absorption, distribution, metabolism, and excretion patterns of zearalenone (ZEN) in a Chinese miniature pig breed. The results showed that ZEN was mainly metabolized into alpha-zearalenol (alpha-ZOL), and both ZEN and alpha-ZOL were mostly found in conjugated forms in the plasma, urine, and bile. The concentration and composition patterns of ZEN and its metabolites were tissue-specific, suggesting different roles of the small intestine, liver, kidney, and lung in ZEN metabolism. The plasma concentrations of ZEN + alpha-ZOL were highly correlated with ZEN dietary exposure, indicating their potential as a bioindicator for animal exposure and efficacy evaluation of mycotoxin detoxifiers.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Toxicology
Byron Kuo, Marc A. Beal, John W. Wills, Paul A. White, Francesco Marchetti, Andy Nong, Tara S. Barton-Maclaren, Keith Houck, Carole L. Yauk
Summary: Risk assessments are increasingly relying on in vitro assays for genotoxicity testing. This study evaluated 292 chemical datasets using the in vitro micronucleus test (MNvit) for hazard identification. The results identified 157 clastogenic chemicals, 25 negatives, and 110 inconclusive substances. In vitro to in vivo extrapolation (IVIVE) was used to convert concentrations into administered equivalent doses (AEDs), which were generally lower than points of departure (PODs) based on in vivo endpoints. Exposure estimates were utilized to calculate bioactivity exposure ratio (BER) values, identifying chemicals that may require additional testing.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Ruiguo Wang, Na Cui, Alexandros Yiannikouris, Yuan Huang, Wenyu Zhao, Xiaoou Su, Gang Lin, Ronghua Zhu, Zhichao Song, Peilong Wang
Summary: Research on the ADME of ZEN in Bama Aroma pigs revealed that ZEN is mainly metabolized into alpha-Zearalenol and both are found in conjugated forms in plasma, urine, and bile. The concentration and composition of ZEN and its metabolites were tissue-specific, suggesting different roles in ZEN metabolism for the small intestine, liver, kidney, and lung.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Environmental Sciences
Cengiz Kaya, Ali Sarioglu, Muhammad Ashraf, Mohammed Nasser Alyemeni, Parvaiz Ahmad
Summary: The joint application of melatonin and salicylic acid improved the tolerance of pepper plants to arsenic toxicity by enhancing nitrogen metabolism and reducing tissue arsenic content.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Zheng Zhang, Xuewei Li, Jia Li, Yupeng Pan, Zile Zhuang, Xiaofeng Zhang, Canbin Chen, Yinglin Liu, Liwen Zhang, Yuxuan Luo, Fei Liu, Haoliang Fan, Qizhi Luo, Xuncai Chen
Summary: This study aimed to reveal the adsorption mechanism of different forms of arsenic onto PSMP and investigate the effects of PSMP on tissue accumulation and developmental toxicity in zebrafish larvae. The results showed that PSMP had a higher adsorption ability for As(III) than DMAs, with hydrogen bonding playing an important role in the process. PSMP reduced the accumulation of As(III) and increased hatching rates in zebrafish larvae, but had no significant effect on DMAs accumulation. PSMP+As(III) exhibited more severe oxidative stress at later stages of zebrafish larvae development.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Environmental Sciences
Valentin Tastet, Marc Le Vee, Arnaud Bruyere, Olivier Fardel
Summary: Human membrane drug transporters interact with chemical additives present in plastics, which can affect the toxicokinetics and toxicity of these pollutants. In vitro assays have shown that various plastic additives can inhibit the activities of drug transporters. The low concentration of plastic additives from environmental or dietary exposure is an important factor to consider for their in vivo relevance.
ENVIRONMENTAL POLLUTION
(2023)
Article
Engineering, Environmental
Mohammad Golam Mostofa, Md Mezanur Rahman, Kien Huu Nguyen, Weiqiang Li, Yasuko Watanabe, Cuong Duy Tran, Minghui Zhang, Misao Itouga, Masayuki Fujita, Lam-Son Phan Tran
Summary: The study revealed that strigolactones are involved in mitigating arsenic stress in rice roots by regulating arsenate uptake, glutathione biosynthesis, vacuolar sequestration of arsenic, and antioxidant defense responses.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Engineering, Environmental
Ronald A. Glabonjat, Georg Raber, Benjamin A. S. Van Mooy, Kevin A. Francesconi
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
B. Witt, J. Bornhorst, H. Mitze, F. Ebert, S. Meyer, K. A. Francesconi, T. Schwerdtle
Article
Chemistry, Applied
Xinwei Yu, Chan Xiong, Kenneth B. Jensen, Ronald A. Glabonjat, Michael Stiboller, Georg Raber, Kevin A. Francesconi
Article
Biochemistry & Molecular Biology
Ronald A. Glabonjat, Josef Ehgartner, Elliott G. Duncan, Georg Raber, Kenneth B. Jensen, Frank Krikowa, William A. Maher, Kevin A. Francesconi
Article
Environmental Sciences
Claudio Zaccone, Daniela Lobianco, Georg Raber, Valeria D'Orazio, William Shotyk, Teodoro M. Miano, Kevin Francesconi
SCIENCE OF THE TOTAL ENVIRONMENT
(2018)
Review
Chemistry, Analytical
Julia Bornhorst, Anna P. Kipp, Hajo Haase, Soeren Meyer, Tanja Schwerdtle
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2018)
Article
Engineering, Environmental
Marta Calatayud, Chan Xiong, Gijs Du Laing, Georg Raber, Kevin Francesconi, Tom van de Wiele
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2018)
Article
Engineering, Environmental
Xi-Mei Xue, Jun Ye, Georg Raber, Barry P. Rosen, Kevin Francesconi, Chan Xiong, Zhe Zhu, Christopher Rensing, Yong-Guan Zhu
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2019)
Article
Environmental Sciences
Nguyen Dang Giang Chau, Nguyen Van Hop, Hoang Thai Long, Ngo Thi My Duyen, Georg Raber
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
(2020)
Article
Engineering, Environmental
Ronald A. Glabonjat, Georg Raber, Henry C. Holm, Benjamin A. S. Van Mooy, Kevin A. Francesconi
Summary: The study found arsenolipids in 61 plankton samples with varying levels of nutrients in the North Atlantic Ocean. The relative amounts of six identified arsenolipids in the samples showed a clear dependence on the nutrient status of the surrounding water. By combining field data with global phytoplankton productivity, it is estimated that oceans' phytoplankton convert 50,000-100,000 tons of arsenic into arsenolipids annually.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Georg Raber, Sonja Weishaupt, Fabian Lappi, Michael Stiboller, Joerg Feldmann
Summary: A new analytical method using gas chromatography-mass spectrometry (GC-MS) was developed for the quantitative determination of arsenic-containing hydrocarbons (AsHCs) in marine samples. The novel method allows for compound independent quantification using triphenylarsine (TPA) as a commercially available standard, expanding the screening application for these toxic compounds in the environment.
ENVIRONMENTAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Hannah Finke, Viktoria K. Wandt, Franziska Ebert, Nikolaus Guttenberger, Ronald A. Glabonjat, Michael Stiboller, Kevin A. Francesconi, Georg Raber, Tanja Schwerdtle
Article
Chemistry, Analytical
Michael Stiboller, Fabiana P. Freitas, Kevin A. Francesconi, Tanja Schwerdtle, Antonio J. A. Nogueira, Georg Raber
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2019)
Article
Toxicology
S. M. Mueller, F. Ebert, G. Raber, S. Meyer, J. Bornhorst, S. Huwel, H. -J. Galla, K. A. Francesconi, T. Schwerdtle
ARCHIVES OF TOXICOLOGY
(2018)
Article
Toxicology
Barbara Witt, Soeren Meyer, Franziska Ebert, Kevin A. Francesconi, Tanja Schwerdtle
ARCHIVES OF TOXICOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Sadia Anjum, Hamile Ali, Faiza Naseer, Maisa S. Abduh, Halima Qadir, Salik Kakar, Yasir Waheed, Tahir Ahmad
Summary: This study demonstrates that avocado and papaya fruit juices can reduce the accumulation of cadmium in the liver, kidney, and hippocampal tissues, and upregulate the expression of antioxidant enzymes while reducing lipid peroxidation. Compared to avocado, papaya has a stronger potential for improving memory and learning, as well as reducing lipid peroxidation in various tissues.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Celio Junior da C. Fernandes, Gerson Santos de Almeida, Patricia Fretes Wood, Anderson M. Gomes, Fabio J. Bezerra, Jose C. S. Vieira, Pedro M. Padilha, Willian F. Zambuzzi
Summary: This study demonstrates the role of mechanosignaling in the promotion of an osteoblastic phenotype in response to zirconia exposure. The release of angiocrine factors modulated by mechanosignaling is crucial in creating a microenvironment that promotes wound healing and osseointegration. These findings highlight the importance of considering endothelial cell mechanosignaling in bone healing and osseointegration in the context of blood vessel effects.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Rehab I. Abdel-Karim, Rania K. Hashish, Dahlia I. Badran, Sally S. Mohammed, Noha A. Salem
Summary: The study found that chlorpyrifos has hepatotoxicity, while cerium oxide nanoparticles can alleviate this toxicity. Cerium oxide nanoparticles can protect the liver by reducing the expression of inflammatory and apoptotic proteins and increasing the activity of antioxidant enzymes.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Tahani El Ayari, Raja Ben Ahmed, Zaineb Hammemi, Abdessalem Kouki, Emna Chelb, Salwa Nechi, Najoua Trigui El Menif
Summary: This study assessed the effects of samarium doped zinc oxide nanoparticles (Sm doped ZnO NPs) on the edible mussel Mytilus galloprovincialis and found that it led to a decrease in filtration rates and histopathological alterations in the gills, digestive glands, and gonads.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shanshan Niu, Zhangmin Wang, Xuebin Yin, Xiaodong Liu, Liqiang Qin, Muhammad Raza Farooq, Ofori Prince Danso, Zezhou Zhang, Qin Luo, Chenlu Sun, Jiaping Song
Summary: This study investigated the transport of selenium through the soil-crop-human chain in regions with different selenium levels. It found that the residents' dietary selenium intake was related to the selenium content in soil, with one village within the WHO recommended intake range while the other village was at risk of selenium deficiency. There were significant positive correlations between residents' dietary selenium intake and the three selenium biomarkers.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Sanaz Salaramoli, Hamid Reza Joshaghani, Ali Shoeibi, Seyed Isaac Hashemy
Summary: The study suggests that serum levels of selenium and selenoprotein P may serve as biomarkers or risk factors for Parkinson's disease. Additionally, there is a correlation between alpha-synuclein levels and disease stage. Further research is needed to understand the role of selenoprotein S in reducing alpha-synuclein aggregation.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Motozumi Ando, Keiko Suzuki, Riko Kitamoto, Ayako Nakayama, Norio Watanabe, Masami Kawahara
Summary: C57BL/6 mice and BALB/c mice showed different expression profiles of selenoprotein P after a high-fat diet (HFD). C57BL/6 mice in the HFD group had higher body weight, fasting plasma glucose levels, and plasma selenoprotein P levels compared to the ND group. However, BALB/c mice did not show significant differences in fasting plasma selenoprotein P levels between the HFD and ND groups.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ruihan Song, Huanhuan Chen, Runqing Zhan, Miaomiao Han, Longzhu Zhao, Xiaoli Shen
Summary: This study aims to investigate the protective effects of Vitamin E (Vit E) on manganese (Mn)-induced nigrostriatal system lesions. The results demonstrate that Vit E improves behavioral disorders, attenuates the loss of nigral dopaminergic neurons, and restores mitochondrial function. Additionally, the protective effect of Vit E may be associated with the upregulation of CHRM1 and KCNJ4 mRNA.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jose Luan da Paixao Teixeira, Ana Paula Rebellato, Maria Isabel Andrekowisk Fioravanti, Raquel Fernanda Milani, Marcelo Antonio Morgano
Summary: The study aimed to determine the total Se content and bioaccessibility in commercial plant-based beverages, with results showing that only one beverage made from organic cashew nuts could meet the recommended Se intake for different populations. High bioacessibility percentages were observed in the beverages.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Andreas F. Lehner, Sarah Rebolloso, Paul P. Calle, Karen Ingerman, Gregory A. Lewbart, Juan Pablo Munoz-Perez, Carlos A. Valle, John P. Buchweitz
Summary: The dried blood spot (DBS) technology is useful for storing blood samples from wildlife, and this study developed methods for measuring several important elements in DBS and used them for health assessments of Galapagos land iguanas. The results showed that the DBS samples accurately reflected the concentrations of various elements compared to plasma samples, with some divergences observed between different species.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Zhou, Chunbei Zhou, Jun Xie, Fei Luo, Ning Yao
Summary: The study illustrates the changes in iodized salt usage, goiter rate, and median urinary iodine concentration in school-aged children in Chongqing over the past 21 years. Adequate iodized salt consumption can eliminate iodine deficiency disorders in children, but excessive iodine intake from salt can lead to high urinary iodine excretion and even goiter. Continuous monitoring and adjustment of iodine fortification levels in household table salt is crucial.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Agustin B. Actis Dato, Valeria R. Martinez, Jorge O. Velez Rueda, Enrique L. Portiansky, Veronica De Giustu, Evelina G. Ferrer, Patricia A. M. Williams
Summary: The zinc coordination complex ZnMD, synthesized in this study, showed promising effects in treating hypertension and cardiac hypertrophy. It was more effective than the antihypertensive drug MD in reducing blood pressure and preventing myocardial hypertrophy. ZnMD also exhibited protective effects on the heart by reducing oxidative damage and regulating the expression of oxidative enzymes. These findings suggest that ZnMD has the potential to be developed as a therapeutic drug for hypertension and cardiac dysfunction.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mina Sarani, Maryam Roostaee, Mahboubeh Adeli-Sardou, Davood Kalantar-Neyestanaki, Seyed Amin Ayatollahi Mousavi, Azam Amanizadeh, Mahmood Barani, Alireza Amirbeigi
Summary: This study successfully synthesized nano bismuth oxide using green synthesis methods. The nano particles doped with silver and copper demonstrated excellent antibacterial properties and selective cytotoxicity against cancer cells. These findings have important implications for biomedical and therapeutic applications.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mona Abdel-Rahman, Heba M. Elmasry, Omar A. Ahmed-Farid, Sherein M. Hegazy, Mohamed M. Rezk
Summary: This study investigates the neuro effects of lanthanides on different brain areas in rats and finds that they can distribute and accumulate in various brain regions. Treatment with cerium nanoparticles or lanthanum causes a significant decrease in norepinephrine, dopamine, serotonin, and GABA, accompanied by a significant increase in 5-hydroxyl indoleacetic acid levels. Moreover, cerium nanoparticles exhibit high activity in scavenging free radicals.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mahshid Deldar Abad Paskeh, Nahid Babaei, Mehrdad Hashemi, Abbas Doosti, Kiavash Hushmandi, Maliheh Entezari, Saeed Samarghandian
Summary: The combination of curcumin, vitamins D and E with Fe2O3-NPs and MnO2-NPs has shown to improve semen parameters and reduce apoptosis in germ cells in rats with testicular hyperthermia. This study suggests that this combination therapy may have a positive effect on fertility and decreasing the toxic effects of nanoparticles.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)