Structural and functional insights into enzymes of the vitamin K cycle

Characterization of vitamin K-dependent carboxylase mutations that cause bleeding and nonbleeding disorders

(2016) J.-K. Tie et al.   BLOOD

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain

(2015) Michael Caspers et al.   THROMBOSIS RESEARCH

Regulation of energy metabolism by the skeleton: Osteocalcin and beyond

(2014) Mathieu Ferron et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A Conformational Investigation of Propeptide Binding to the Integral Membrane Protein γ-Glutamyl Carboxylase Using Nanodisc Hydrogen Exchange Mass Spectrometry

(2014) Christine H. Parker et al.   BIOCHEMISTRY

Disulfide bond formation in prokaryotes: History, diversity and design

(2014) Feras Hatahet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Arg98Trp mutation in human VKORC1 causing VKCFD2 disrupts a di-arginine-based ER retention motif

(2014) K. J. Czogalla et al.   BLOOD

Conserved Loop Cysteines of Vitamin K Epoxide Reductase Complex Subunit 1-like 1 (VKORC1L1) Are Involved in Its Active Site Regeneration

(2014) Jian-Ke Tie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retinitis Pigmentosa, Cutis Laxa, and Pseudoxanthoma Elasticum–Like Skin Manifestations Associated with GGCX Mutations

(2014) Ariana Kariminejad et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The realm of vitamin K dependent proteins: Shifting from coagulation toward calcification

(2014) Brecht A. G. Willems et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Liver-Specific γ-Glutamyl Carboxylase-Deficient Mice Display Bleeding Diathesis and Short Life Span

(2014) Kotaro Azuma et al.   PLoS One

Bleeding and non-bleeding phenotypes in patients with GGCX gene mutations

(2014) Matthias Watzka et al.   THROMBOSIS RESEARCH

Assessment of the contribution of NAD(P)H-dependent quinone oxidoreductase 1 (NQO1) to the reduction of vitamin K in wild-type and NQO1-deficient mice

(2013) Brian O. Ingram et al.   BIOCHEMICAL JOURNAL

The Vitamin K Oxidoreductase Is a Multimer That Efficiently Reduces Vitamin K Epoxide to Hydroquinone to Allow Vitamin K-dependent Protein Carboxylation

(2013) Mark A. Rishavy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VKORC1L1, an Enzyme Rescuing the Vitamin K 2,3-Epoxide Reductase Activity in Some Extrahepatic Tissues during Anticoagulation Therapy

(2013) Abdessalem Hammed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of warfarin resistance using transcription activator-like effector nucleases-mediated vitamin K epoxide reductase knockout HEK293 cells

(2013) J.-K. Tie et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Membrane topology for human vitamin K epoxide reductase

(2013) S. Wu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

New insights into the catalytic mechanism of vitamin K epoxide reductase (VKORC1) - The catalytic properties of the major mutations of rVKORC1 explain the biological cost associated to mutations

(2013) Benjamin Matagrin et al.   FEBS Open Bio

Human Vitamin K Epoxide Reductase and Its Bacterial Homologue Have Different Membrane Topologies and Reaction Mechanisms

(2012) Jian-Ke Tie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix Gla protein reinforces angiogenic resolution

(2012) Bikram Sharma et al.   MICROVASCULAR RESEARCH

The role of osteocalcin in human glucose metabolism: marker or mediator?

(2012) Sarah L. Booth et al.   Nature Reviews Endocrinology

Vitamin K Oxygenation, Glutamate Carboxylation, and Processivity: Defining the Three Critical Facets of Catalysis by the Vitamin K–Dependent Carboxylase

(2012) Mark A. Rishavy et al.   Advances in Nutrition

Vitamin K-Dependent Carboxylation of Osteocalcin: Friend or Foe?

(2012) Caren M. Gundberg et al.   Advances in Nutrition

Mycobacterium tuberculosis Vitamin K Epoxide Reductase Homologue Supports Vitamin K–Dependent Carboxylation in Mammalian Cells

(2011) Jian-Ke Tie et al.   ANTIOXIDANTS & REDOX SIGNALING

Functional study of the vitamin K cycle in mammalian cells

(2011) J.-K. Tie et al.   BLOOD

Human Vitamin K 2,3-Epoxide Reductase Complex Subunit 1-like 1 (VKORC1L1) Mediates Vitamin K-dependent Intracellular Antioxidant Function

(2011) Philipp Westhofen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Topology and Mutational Analysis of Mycobacterium tuberculosis VKOR, a Protein Involved in Disulfide Bond Formation and a Homologue of Human Vitamin K Epoxide Reductase

(2010) Xiaoyun Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Quantum chemical study of the mechanism of action of vitamin K carboxylase in solvent

(2010) Sangwook Wu et al.   INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY

Effect of Vitamin K-dependent Protein Precursor Propeptide, Vitamin K Hydroquinone, and Glutamate Substrate Binding on the Structure and Function of γ-Glutamyl Carboxylase

(2010) Shannon L. Higgins-Gruber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low serum vitamin K in PXE results in defective carboxylation of mineralization inhibitors similar to the GGCX mutations in the PXE-like syndrome

(2010) Olivier M Vanakker et al.   LABORATORY INVESTIGATION

Structure of a bacterial homologue of vitamin K epoxide reductase

(2010) Weikai Li et al.   NATURE

Hereditary combined deficiency of the vitamin K-dependent clotting factors

(2010) Mariasanta Napolitano et al.   Orphanet Journal of Rare Diseases

Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners

(2010) S. Schulman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmembrane Domain Interactions and Residue Proline 378 Are Essential for Proper Structure, Especially Disulfide Bond Formation, in the Human Vitamin K-Dependent γ-Glutamyl Carboxylase†

(2008) Jian-Ke Tie et al.   BIOCHEMISTRY