Factor XII: form determines function

Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations

(2016) Steven de Maat et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Challenging the anticoagulant paradigm?

(2016) H. ten Cate   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Contact system revisited: an interface between inflammation, coagulation, and innate immunity

(2016) A. T. Long et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The contact activation and kallikrein/kinin systems: pathophysiologic and physiologic activities

(2016) A. H. Schmaier   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Elevated D-dimers in attacks of hereditary angioedema are not associated with increased thrombotic risk

(2015) A. Reshef et al.   ALLERGY

Plasma contact system activation drives anaphylaxis in severe mast cell–mediated allergic reactions

(2015) Anna Sala-Cunill et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III

(2015) Jenny Björkqvist et al.   JOURNAL OF CLINICAL INVESTIGATION

Orolingual Angiodema Associated with Alteplase Treatment of Acute Stroke: A Reappraisal

(2015) Ana Sofia Correia et al.   Journal of Stroke & Cerebrovascular Diseases

Coagulation factor XII protease domain crystal structure

(2015) M. Pathak et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Negatively charged silver nanoparticles cause retinal vascular permeability by activating plasma contact system and disrupting adherens junction

(2015) Yan-Min Long et al.   Nanotoxicology

Orolingual Angiodema Associated with Alteplase Treatment of Acute Stroke: A Reappraisal

(2015) Ana Sofia Correia et al.   Journal of Stroke & Cerebrovascular Diseases

Size-Controlled Synthesis of Granular Polyphosphate Nanoparticles at Physiologic Salt Concentrations for Blood Clotting

(2014) Alexander J. Donovan et al.   BIOMACROMOLECULES

Tranexamic acid as maintenance treatment for non-histaminergic angioedema: analysis of efficacy and safety in 37 patients

(2014) C. Wintenberger et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Orolingual angioedema after alteplase therapy of acute ischaemic stroke: incidence and risk of prior angiotensin-converting enzyme inhibitor use

(2014) S.-Y. Lin et al.   EUROPEAN JOURNAL OF NEUROLOGY

Characterization of a partial exon 9/intron 9 deletion in the coagulation factor XII gene (F12) detected in two Turkish families with hereditary angioedema and normal C1 inhibitor

(2014) K. Bork et al.   HAEMOPHILIA

Tracking down contact activation - from coagulationin vitroto inflammationin vivo

(2014) S. de Maat et al.   International Journal of Laboratory Hematology

Single-chain factor XII exhibits activity when complexed to polyphosphate

(2014) R. Engel et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A Factor XIIa Inhibitory Antibody Provides Thromboprotection in Extracorporeal Circulation Without Increasing Bleeding Risk

(2014) M. Larsson et al.   Science Translational Medicine

Contact System Activation on Endothelial Cells

(2014) Steven de Maat et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Zinc-dependent contact system activation induces vascular leakage and hypotension in rodents

(2013) Jenny Björkqvist et al.   BIOLOGICAL CHEMISTRY

The transition of prothrombin to thrombin

(2013) S. Krishnaswamy   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A nanobody-based method for tracking factor XII activation in plasma

(2013) Steven de Maat et al.   THROMBOSIS AND HAEMOSTASIS

In vivo roles of factor XII

(2012) T. Renne et al.   BLOOD

Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure

(2012) Hiromi Nabeshi et al.   NANOTECHNOLOGY

Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding

(2011) A. S. Revenko et al.   BLOOD

A novel mutation in the coagulation factor 12 gene in subjects with hereditary angioedema and normal C1-inhibitor

(2011) Konrad Bork et al.   CLINICAL IMMUNOLOGY

Mast Cells Increase Vascular Permeability by Heparin-Initiated Bradykinin Formation In Vivo

(2011) Chris Oschatz et al.   IMMUNITY

The Plasma Contact System 2.0

(2011) Coen Maas et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

TREATMENT OF HEREDITARY ANGIONEUROTIC OEDEMA WITH TRANEXAMIC ACID

(2010) G. Blohmé   ACTA MEDICA SCANDINAVICA

A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo

(2010) Q. Cheng et al.   BLOOD

Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis

(2010) G. A. LaRusch et al.   BLOOD

Polyphosphate exerts differential effects on blood clotting, depending on polymer size

(2010) S. A. Smith et al.   BLOOD

Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo

(2009) Felicitas Müller et al.   CELL

Contact activation of kallikrein–kinin system by superparamagnetic iron oxide nanoparticles in vitro and in vivo

(2009) Dmitri Simberg et al.   JOURNAL OF CONTROLLED RELEASE

Ir-CPI, a coagulation contact phase inhibitor from the tickIxodes ricinus, inhibits thrombus formation without impairing hemostasis

(2009) Yves Decrem et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antiphospholipid antibodies and risk of myocardial infarction and ischaemic stroke in young women in the RATIO study: a case-control study

(2009) Rolf T Urbanus et al.   LANCET NEUROLOGY

A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

(2009) Warwick S Nesbitt et al.   NATURE MEDICINE

Factor XII: What does it contribute to our understanding of the physiology and pathophysiology of hemostasis & thrombosis

(2009) Evi Stavrou et al.   THROMBOSIS RESEARCH

Identification of fibronectin type I domains as amyloid-binding modules on tissue-type plasminogen activator and three homologs

(2008) Coen Maas et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System

(2008) Takashi Kei Kishimoto et al.   NEW ENGLAND JOURNAL OF MEDICINE

Finding seconds count after contact with blood (and that is all I did)

(2007) Leo Vroman   COLLOIDS AND SURFACES B-BIOINTERFACES