Characterization of Virus Particles and Submicron-Sized Particulate Impurities in Recombinant Adeno-Associated Virus Drug Product

Rapid characterization of adeno-associated virus (AAV) gene therapy vectors by mass photometry

(2022) Di Wu et al.   GENE THERAPY

Systematic Studies on Stabilization of AAV Vector Formulations by Lyophilization

(2022) Ruth Rieser et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mechanistic Studies and Formulation Mitigations of Adeno-associated Virus Capsid Rupture During Freezing and Thawing

(2022) Jared S. Bee et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Analysis of thermally driven structural changes, genome release, disassembly, and aggregation of recombinant AAV by CDMS

(2022) Lauren F. Barnes et al.   Molecular Therapy-Methods & Clinical Development

Comprehensive characterization and quantification of adeno associated vectors by size exclusion chromatography and multi angle light scattering

(2021) Nicole L. McIntosh et al.   Scientific Reports

Analytical methods for process and product characterization of recombinant adeno-associated virus-based gene therapies

(2021) Andreas L. Gimpel et al.   Molecular Therapy-Methods & Clinical Development

Manufacturing Challenges and Rational Formulation Development for AAV viral vectors

(2021) Arvind Srivastava et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Comparison of Different Liquid Chromatography-Based Purification Strategies for Adeno-Associated Virus Vectors

(2021) Ruth Rieser et al.   Pharmaceutics

Characterization of Recombinant Adeno-Associated Viruses (rAAVs) for Gene Therapy Using Orthogonal Techniques

(2021) Liam Cole et al.   Pharmaceutics

Next Step in Gene Delivery: Modern Approaches and Further Perspectives of AAV Tropism Modification

(2021) Maxim A. Korneyenkov et al.   Pharmaceutics

Adeno-associated Virus Virus-like Particle Characterization via Orthogonal Methods: Nanoelectrospray Differential Mobility Analysis, Asymmetric Flow Field-Flow Fractionation, and Atomic Force Microscopy

(2021) Samuele Zoratto et al.   ACS Omega

Comprehensive Size Distribution and Composition Analysis of Adeno-Associated Virus Vector by Multiwavelength Sedimentation Velocity Analytical Ultracentrifugation

(2021) Takahiro Maruno et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Particles in Biopharmaceutical Formulations, Part 2: An Update on Analytical Techniques and Applications for Therapeutic Proteins, Viruses, Vaccines and Cells

(2021) Alexandra Roesch et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Engineering adeno-associated virus vectors for gene therapy

(2020) Chengwen Li et al.   NATURE REVIEWS GENETICS

Quality Control Testing, Characterization and Critical Quality Attributes of Adeno‐Associated Virus Vectors Used for Human Gene Therapy

(2020) J. Fraser Wright   Biotechnology Journal

Particle Detection and Characterization for Biopharmaceutical Applications: Current Principles of Established and Alternative Techniques

(2020) Julia Gross-Rother et al.   Pharmaceutics

Accurate Quantification and Characterization of Adeno-Associated Viral Vectors

(2019) David Dobnik et al.   Frontiers in Microbiology

Asymmetrical Flow Field-Flow Fractionation on Virus and Virus-Like Particle Applications

(2019) Katri Eskelin et al.   Microorganisms

Characterization of AAV vector particle stability at the single-capsid level

(2018) Julien Bernaud et al.   JOURNAL OF BIOLOGICAL PHYSICS

Quantitative mass imaging of single biological macromolecules

(2018) Gavin Young et al.   SCIENCE

Universal Method for the Purification of Recombinant AAV Vectors of Differing Serotypes

(2018) Shelley A. Nass et al.   Molecular Therapy-Methods & Clinical Development

Critical evaluation of microfluidic resistive pulse sensing for quantification and sizing of nanometer- and micrometer-sized particles in biopharmaceutical products

(2018) Adam D. Grabarek et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Direct Head-to-Head Evaluation of Recombinant Adeno-associated Viral Vectors Manufactured in Human versus Insect Cells

(2017) Oleksandr Kondratov et al.   MOLECULAR THERAPY

Improving the Quality of Adeno-Associated Viral Vector Preparations: The Challenge of Product-Related Impurities

(2017) Maria Schnödt et al.   Human Gene Therapy Methods

Label-Free Single-Molecule Imaging with Numerical-Aperture-Shaped Interferometric Scattering Microscopy

(2017) Daniel Cole et al.   ACS Photonics

Resolving Adeno-Associated Viral Particle Diversity With Charge Detection Mass Spectrometry

(2016) Elizabeth E. Pierson et al.   ANALYTICAL CHEMISTRY

Measurement of the Average Mass of Proteins Adsorbed to a Nanoparticle by Using a Suspended Microchannel Resonator

(2015) M. Reza Nejadnik et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Basic Biology of Adeno-Associated Virus (AAV) Vectors Used in Gene Therapy

(2014) Balaji Balakrishnan et al.   CURRENT GENE THERAPY

Resolving power of dynamic light scattering for protein and polystyrene nanoparticles

(2014) Anne R. Karow et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

AAV-Mediated Gene Therapy for Research and Therapeutic Purposes

(2014) R. Jude Samulski et al.   Annual Review of Virology

iCLIP: Protein–RNA interactions at nucleotide resolution

(2013) Ina Huppertz et al.   METHODS

Biophysical and Ultrastructural Characterization of Adeno-Associated Virus Capsid Uncoating and Genome Release

(2012) E. D. Horowitz et al.   JOURNAL OF VIROLOGY

Particles in Therapeutic Protein Formulations, Part 1: Overview of Analytical Methods

(2011) Sarah Zölls et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development

(2010) John den Engelsman et al.   PHARMACEUTICAL RESEARCH

Reversal of Blindness in Animal Models of Leber Congenital Amaurosis Using Optimized AAV2-mediated Gene Transfer

(2008) Jeannette Bennicelli et al.   MOLECULAR THERAPY