Next Step in Gene Delivery: Modern Approaches and Further Perspectives of AAV Tropism Modification

Engineering adeno-associated virus vectors for gene therapy

(2020) Chengwen Li et al.   NATURE REVIEWS GENETICS

Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types

(2020) Sripriya Ravindra Kumar et al.   NATURE METHODS

Engineered Capsids for Efficient Gene Delivery to the Retina and Cornea

(2020) Amy Frederick et al.   HUMAN GENE THERAPY

ICTV Virus Taxonomy Profile: Parvoviridae

(2019) Susan F. Cotmore et al.   JOURNAL OF GENERAL VIROLOGY

Gene delivery to cone photoreceptors by subretinal injection of rAAV2/6 in the mouse retina

(2019) Tesshu Hori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A User's Guide to the Inverted Terminal Repeats of Adeno-Associated Virus

(2019) Patrick Wilmott et al.   Human Gene Therapy Methods

Programmable Assembly of Adeno-Associated Virus–Antibody Composites for Receptor-Mediated Gene Delivery

(2019) Alina C. Zdechlik et al.   BIOCONJUGATE CHEMISTRY

High-Throughput Dissection of AAV–Host Interactions: The Fast and the Curious

(2018) Anne-Kathrin Herrmann et al.   JOURNAL OF MOLECULAR BIOLOGY

In Vivo Selection of a Computationally Designed SCHEMA AAV Library Yields a Novel Variant for Infection of Adult Neural Stem Cells in the SVZ

(2018) David S. Ojala et al.   MOLECULAR THERAPY

Neuraminidase-mediated desialylation augments AAV9-mediated gene expression in skeletal muscle

(2018) Hongling Zhu et al.   JOURNAL OF GENE MEDICINE

Unraveling the Complex Story of Immune Responses to AAV Vectors Trial After Trial

(2017) Céline Vandamme et al.   HUMAN GENE THERAPY

Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c

(2017) Bifeng Pan et al.   NATURE BIOTECHNOLOGY

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

(2017) Ken Y Chan et al.   NATURE NEUROSCIENCE

Host determinants of adeno-associated viral vector entry

(2017) Sirika Pillay et al.   Current Opinion in Virology

Direct Liquid Chromatography/Mass Spectrometry Analysis for Complete Characterization of Recombinant Adeno-Associated Virus Capsid Proteins

(2017) Xiaoying Jin et al.   Human Gene Therapy Methods

A Precise Chemical Strategy To Alter the Receptor Specificity of the Adeno-Associated Virus

(2016) Rachel E. Kelemen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Viral vectors for gene therapy: Current state and clinical perspectives

(2016) A. N. Lukashev et al.   BIOCHEMISTRY-MOSCOW

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain

(2016) Benjamin E Deverman et al.   NATURE BIOTECHNOLOGY

AAV ancestral reconstruction library enables selection of broadly infectious viral variants

(2015) J Santiago-Ortiz et al.   GENE THERAPY

Comparative Study of Liver Gene Transfer With AAV Vectors Based on Natural and Engineered AAV Capsids

(2015) Lili Wang et al.   MOLECULAR THERAPY

In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector

(2015) Eric Zinn et al.   Cell Reports

Vector Design Tour de Force: Integrating Combinatorial and Rational Approaches to Derive Novel Adeno-associated Virus Variants

(2014) Damien Marsic et al.   MOLECULAR THERAPY

Selection and evaluation of clinically relevant AAV variants in a xenograft liver model

(2013) Leszek Lisowski et al.   NATURE

AAVs Anatomy: Roadmap for Optimizing Vectors for Translational Success

(2012) Angela M. Mitchell et al.   CURRENT GENE THERAPY

Oligomeric Properties of Adeno-Associated Virus Rep68 Reflect Its Multifunctionality

(2012) F. Zarate-Perez et al.   JOURNAL OF VIROLOGY

Site-Specific Modification of Adeno-Associated Viruses via a Genetically Engineered Aldehyde Tag

(2012) Yarong Liu et al.   Small

Engineering Liver-detargeted AAV9 Vectors for Cardiac and Musculoskeletal Gene Transfer

(2011) Nagesh Pulicherla et al.   MOLECULAR THERAPY

Phase 1 Gene Therapy for Duchenne Muscular Dystrophy Using a Translational Optimized AAV Vector

(2011) Dawn E Bowles et al.   MOLECULAR THERAPY

A viral assembly factor promotes AAV2 capsid formation in the nucleolus

(2010) F. Sonntag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals

(2010) C.-S. Hwang et al.   SCIENCE

AAV9-mediated erythropoietin gene delivery into the brain protects nigral dopaminergic neurons in a rat model of Parkinson's disease

(2009) Y-Q Xue et al.   GENE THERAPY

Effect of Adeno-Associated Virus Serotype and Genomic Structure on Liver Transduction and Biodistribution in Mice of Both Genders

(2009) Astrid Pañeda et al.   HUMAN GENE THERAPY

Efficient intracerebral delivery of AAV5 vector encoding human ARSA in non-human primate

(2009) M.-A. Colle et al.   HUMAN MOLECULAR GENETICS

Engineering adeno-associated virus serotype 2-based targeting vectors using a new insertion site-position 453-and single point mutations

(2009) Jorge Boucas et al.   JOURNAL OF GENE MEDICINE

Intravenous Administration of Self-complementary AAV9 Enables Transgene Delivery to Adult Motor Neurons

(2009) Sandra Duque et al.   MOLECULAR THERAPY

Recirculating cardiac delivery of AAV2/1SERCA2a improves myocardial function in an experimental model of heart failure in large animals

(2008) M J Byrne et al.   GENE THERAPY

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

(2008) Salima Hacein-Bey-Abina et al.   JOURNAL OF CLINICAL INVESTIGATION

Systemic AAV6 Delivery Mediating RNA Interference Against SOD1: Neuromuscular Transduction Does Not Alter Disease Progression in fALS Mice

(2008) Chris Towne et al.   MOLECULAR THERAPY

Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection

(2008) Carmela Zincarelli et al.   MOLECULAR THERAPY

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY