Knockout of TRDMT1 methyltransferase affects DNA methylome in glioblastoma cells

Deficiency of TRDMT1 impairs exogenous RNA-based response and promotes retrotransposon activity during long-term culture of osteosarcoma cells

(2022) Gabriela Betlej et al.   TOXICOLOGY IN VITRO

DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis

(2022) Jagoda Adamczyk-Grochala et al.   APOPTOSIS

The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence

(2021) Dominika Bloniarz et al.   Aging-US

m5C modification of mRNA serves a DNA damage code to promote homologous recombination

(2020) Hao Chen et al.   Nature Communications

Depletion of TRDMT1 affects 5-methylcytosine modification of mRNA and inhibits HEK293 cell proliferation and migration

(2019) Songlei Xue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression

(2018) Anna Lewinska et al.   Redox Biology

The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space

(2018) Johanna Klughammer et al.   NATURE MEDICINE

Downregulation of methyltransferase Dnmt2 results in condition-dependent telomere shortening and senescence or apoptosis in mouse fibroblasts

(2017) Anna Lewinska et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Spatiotemporal genomic architecture informs precision oncology in glioblastoma

(2017) Jin-Ku Lee et al.   NATURE GENETICS

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

(2016) Michele Ceccarelli et al.   CELL

CpG sites with continuously increasing or decreasing methylation from early to late human fetal brain development

(2016) Eberhard Schneider et al.   GENE

Clonal evolution of glioblastoma under therapy

(2016) Jiguang Wang et al.   NATURE GENETICS

Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity

(2015) Mona Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells

(2015) Anna Lewinska et al.   TOXICOLOGY LETTERS

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

(2010) M. Schaefer et al.   GENES & DEVELOPMENT

BSMAP: whole genome bisulfite sequence MAPping program

(2009) Yuanxin Xi et al.   BMC BIOINFORMATICS

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE