Deficiency of TRDMT1 impairs exogenous RNA-based response and promotes retrotransposon activity during long-term culture of osteosarcoma cells

Exogenous Coronavirus Interacts With Endogenous Retrotransposon in Human Cells

(2021) Ying Yin et al.   Frontiers in Cellular and Infection Microbiology

The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence

(2021) Dominika Bloniarz et al.   Aging-US

Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme

(2020) Mathilde Cheray et al.   Molecular Cancer

m5C modification of mRNA serves a DNA damage code to promote homologous recombination

(2020) Hao Chen et al.   Nature Communications

Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks

(2019) Kaspar Burger et al.   NUCLEIC ACIDS RESEARCH

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

Clinical genomic sequencing of pediatric and adult osteosarcoma reveals distinct molecular subsets with potentially targetable alterations

(2019) Yoshiyuki Suehara et al.   CLINICAL CANCER RESEARCH

5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs

(2019) Xin Chen et al.   NATURE CELL BIOLOGY

Depletion of TRDMT1 affects 5-methylcytosine modification of mRNA and inhibits HEK293 cell proliferation and migration

(2019) Songlei Xue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RNase H eliminates R‐loops that disrupt DNA replication but is nonessential for efficient DSB repair

(2018) Hongchang Zhao et al.   EMBO REPORTS

Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair

(2018) Wei-Ting Lu et al.   Nature Communications

How RNA transcripts coordinate DNA recombination and repair

(2018) Shane McDevitt et al.   Nature Communications

RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia

(2018) Jason X. Cheng et al.   Nature Communications

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

(2018) Sarah Cohen et al.   Nature Communications

Camptothecin induces G2/M phase arrest through the ATM-Chk2-Cdc25C axis as a result of autophagy-induced cytoprotection: Implications of reactive oxygen species

(2018) Rajapaksha Gedara Prasad Tharanga Jayaso et al.   Oncotarget

Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression

(2018) Anna Lewinska et al.   Redox Biology

Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair

(2018) Takaaki Yasuhara et al.   CELL

RAD52 is required for RNA-templated recombination repair in post-mitotic neurons

(2017) Starr Welty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear phosphorylated Dicer processes double-stranded RNA in response to DNA damage

(2017) Kaspar Burger et al.   JOURNAL OF CELL BIOLOGY

Downregulation of methyltransferase Dnmt2 results in condition-dependent telomere shortening and senescence or apoptosis in mouse fibroblasts

(2017) Anna Lewinska et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Rad52 Inverse Strand Exchange Drives RNA-Templated DNA Double-Strand Break Repair

(2017) Olga M. Mazina et al.   MOLECULAR CELL

Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks

(2017) Flavia Michelini et al.   NATURE CELL BIOLOGY

Bone cancer: Is the osteosarcoma genome targetable?

(2017) Sharon A. Savage et al.   Nature Reviews Endocrinology

Germline and somatic genetics of osteosarcoma — connecting aetiology, biology and therapy

(2017) D. Matthew Gianferante et al.   Nature Reviews Endocrinology

Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation

(2017) Anna Lewinska et al.   Redox Biology

Age-associated de-repression of retrotransposons in theDrosophilafat body, its potential cause and consequence

(2016) Haiyang Chen et al.   AGING CELL

Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair

(2016) Corina Ohle et al.   CELL

Post-transcriptional gene regulation by mRNA modifications

(2016) Boxuan Simen Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span inDrosophila

(2016) Jason G. Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RNA methyltransferase Dnmt2 methylates DNA in the structural context of a tRNA

(2016) Steffen Kaiser et al.   RNA Biology

Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation

(2016) Albert Jeltsch et al.   RNA Biology

Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues

(2016) Marco De Cecco et al.   Aging-US

Structural Chemistry of Human RNA Methyltransferases

(2015) Matthieu Schapira   ACS Chemical Biology

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

(2015) David Roulois et al.   CELL

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

(2015) Katherine B. Chiappinelli et al.   CELL

Type I Interferon Controls Propagation of Long Interspersed Element-1

(2015) Qiujing Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capsaicin-induced genotoxic stress does not promote apoptosis in A549 human lung and DU145 prostate cancer cells

(2015) Anna Lewinska et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination

(2015) Leizhen Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers

(2015) Huili Li et al.   Oncotarget

Long Interspersed Element-1 Protein Expression Is a Hallmark of Many Human Cancers

(2014) Nemanja Rodić et al.   AMERICAN JOURNAL OF PATHOLOGY

The Pivotal Regulatory Landscape of RNA Modifications

(2014) Sheng Li et al.   Annual Review of Genomics and Human Genetics

Transcript-RNA-templated DNA recombination and repair

(2014) Havva Keskin et al.   NATURE

Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

(2014) J. M. C. Tubio et al.   SCIENCE

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

(2014) Michael Van Meter et al.   Nature Communications

Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - Implication in modification of radiation damage

(2014) Anuranjani et al.   Redox Biology

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

(2013) Marco De Cecco et al.   AGING CELL

Suppression of Ku80 Correlates with Radiosensitivity and Telomere Shortening in the U2OS Telomerase-negative Osteosarcoma Cell Line

(2013) Liu Hu et al.   Asian Pacific Journal of Cancer Prevention

Efficient RNA virus control in Drosophila requires the RNA methyltransferase Dnmt2

(2013) Zeljko Durdevic et al.   EMBO REPORTS

SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres

(2013) Bingbing Wan et al.   Cell Reports

Understanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease Progression

(2013) Limin Zhu et al.   Frontiers in Oncology

Site-specific DICER and DROSHA RNA products control the DNA-damage response

(2012) Sofia Francia et al.   NATURE

RNA-driven genetic changes in bacteria and in human cells

(2011) Ying Shen et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Addition of pamidronate to chemotherapy for the treatment of osteosarcoma

(2010) Paul A. Meyers et al.   CANCER

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

(2010) M. Schaefer et al.   GENES & DEVELOPMENT

The ACF1 Complex Is Required for DNA Double-Strand Break Repair in Human Cells

(2010) Li Lan et al.   MOLECULAR CELL

Small RNA sorting: matchmaking for Argonautes

(2010) Benjamin Czech et al.   NATURE REVIEWS GENETICS

Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization

(2009) V Gama et al.   CELL DEATH AND DIFFERENTIATION

Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2

(2009) Sameer Phalke et al.   NATURE GENETICS

Telomere shortening is correlated with the DNA damage response and telomeric protein down-regulation in colorectal preneoplastic lesions

(2008) C. M. Raynaud et al.   ANNALS OF ONCOLOGY

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL