Phosphatidylcholine deficiency increases ferroptosis susceptibility in the Caenorhabditis elegans germline

Search and sequence analysis tools services from EMBL-EBI in 2022

(2022) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Spns1 is a lysophospholipid transporter mediating lysosomal phospholipid salvage

(2022) Menglan He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early-life vitamin B12 orchestrates lipid peroxidation to ensure reproductive success via SBP-1/SREBP1 in Caenorhabditis elegans

(2022) Shenlu Qin et al.   Cell Reports

Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures

(2021) David Sehnal et al.   NUCLEIC ACIDS RESEARCH

Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects

(2021) Emeline Dierge et al.   Cell Metabolism

Ether phospholipids govern ferroptosis

(2021) Hyemin Lee et al.   Journal of Genetics and Genomics

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: Evidence of ferroptosis

(2020) Azhaar Ashraf et al.   Redox Biology

Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans

(2020) Yanan Sun et al.   eLife

Dietary Lipids Induce Ferroptosis in Caenorhabditis elegans and Human Cancer Cells

(2020) Marcos A. Perez et al.   DEVELOPMENTAL CELL

Lysosomal activity regulates Caenorhabditis elegans mitochondrial dynamics through vitamin B12 metabolism

(2020) Wei Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal lipolysis participates in PUFA‐mediated neural function and neurodegeneration

(2020) Leilei Yang et al.   EMBO REPORTS

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

(2020) Yilong Zou et al.   NATURE

Caenorhabditis elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor

(2020) Gabrielle E Giese et al.   eLife

The Metabolic Underpinnings of Ferroptosis

(2020) Jiashuo Zheng et al.   Cell Metabolism

Phospholipid flippases in membrane remodeling and transport carrier biogenesis

(2019) Jordan T Best et al.   CURRENT OPINION IN CELL BIOLOGY

Ferritin heavy chain protects the developing wing from reactive oxygen species and ferroptosis

(2019) Simone Mumbauer et al.   PLoS Genetics

Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms

(2019) Xiao Yang et al.   PLoS Genetics

PCYT1A Regulates Phosphatidylcholine Homeostasis from the Inner Nuclear Membrane in Response to Membrane Stored Curvature Elastic Stress

(2018) Afreen Haider et al.   DEVELOPMENTAL CELL

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish

(2017) Gang Zhai et al.   Journal of Genetics and Genomics

Lipid metabolic perturbation is an early-onset phenotype in adult spinster mutants: a Drosophila model for lysosomal storage disorders

(2017) Sarita Hebbar et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

The lysosomal membrane protein SCAV-3 maintains lysosome integrity and adult longevity

(2016) Yuan Li et al.   JOURNAL OF CELL BIOLOGY

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

(2016) Sung Eun Kim et al.   Nature Nanotechnology

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans Gene Expression and Life History Traits

(2014) Emma Watson et al.   CELL

A Lipid Droplet-Associated GFP Reporter-Based Screen Identifies New Fat Storage Regulators in C. elegans

(2014) Zhenglong Liu et al.   Journal of Genetics and Genomics

Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease

(2014) F. Payne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyunsaturated phospholipids facilitate membrane deformation and fission by endocytic proteins

(2014) M. Pinot et al.   SCIENCE

A sub-nanometre view of how membrane curvature and composition modulate lipid packing and protein recruitment

(2014) Stefano Vanni et al.   Nature Communications

Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency

(2014) Tomoyuki Sasaki et al.   PLoS Genetics

Fertility and Germline Stem Cell Maintenance under Different Diets Requires nhr-114/HNF4 in C. elegans

(2013) Xicotencatl Gracida et al.   CURRENT BIOLOGY

C13C4.5/Spinster, an evolutionarily conserved protein that regulates fertility in C. elegans through a lysosome-mediated lipid metabolism process

(2013) Mei Han et al.   Protein & Cell

Crystal structure of a bacterial homologue of glucose transporters GLUT1–4

(2012) Linfeng Sun et al.   NATURE

A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates Lipogenesis in Metazoans

(2011) Amy K. Walker et al.   CELL

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

Spinster is required for autophagic lysosome reformation and mTOR reactivation following starvation

(2011) Y. Rong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

System xc−and Thioredoxin Reductase 1 Cooperatively Rescue Glutathione Deficiency

(2010) Pankaj Kumar Mandal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian iron transport

(2009) Gregory Jon Anderson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ce-Duox1/BLI-3 Generates Reactive Oxygen Species as a Protective Innate Immune Mechanism in Caenorhabditis elegans

(2009) V. Chavez et al.   INFECTION AND IMMUNITY