Active-targeting long-acting protein-glycopolymer conjugates for selective cancer therapy

LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation

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Precision Conjugation: An Emerging Tool for Generating Protein‐Polymer Conjugates

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Lysosome-targeting chimaeras for degradation of extracellular proteins

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Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

(2019) D. Scott Wilson et al.   NATURE MATERIALS

Synthetically glycosylated antigens induce antigen-specific tolerance and prevent the onset of diabetes

(2019) D. Scott Wilson et al.   Nature Biomedical Engineering

Site-selective protein modification with polymers for advanced biomedical applications

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Polymerization Induced Self-Assembly of a Site-Specific Interferon α-Block Copolymer Conjugate into Micelles with Remarkably Enhanced Pharmacology

(2018) Xinyu Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biopharmaceutical benchmarks 2018

(2018) Gary Walsh   NATURE BIOTECHNOLOGY

Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876

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Site-specific in situ growth of an interferon-polymer conjugate that outperforms PEGASYS in cancer therapy

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Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876

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In situ growth of a C-terminal interferon-alpha conjugate of a phospholipid polymer that outperforms PEGASYS in cancer therapy

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Zwitterionic polymer-protein conjugates reduce polymer-specific antibody response

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PTEN dephosphorylates AKT to prevent the expression of GLUT1 on plasmamembrane and to limit glucose consumption in cancer cells

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One-step synthesis of glycoprotein mimics in vitro: improvement of protein activity, stability and application in CPP hydrolysis

(2016) Yuecheng Cui et al.   Journal of Materials Chemistry B

A brush-polymer/exendin-4 conjugate reduces blood glucose levels for up to five days and eliminates poly(ethylene glycol) antigenicity

(2016) Yizhi Qi et al.   Nature Biomedical Engineering

Enhancing Pharmacokinetics, Tumor Accumulation, and Antitumor Efficacy by Elastin-Like Polypeptide Fusion of Interferon Alpha

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Glycopolymer Nanobiotechnology

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Modulation of Complement Activation and Amplification on Nanoparticle Surfaces by Glycopolymer Conformation and Chemistry

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Recent advances in the preparation of glycopolymer bioconjugates

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Trehalose Glycopolymers for Stabilization of Protein Conjugates to Environmental Stressors

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High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans

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A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner

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In situ growth of a stoichiometric PEG-like conjugate at a protein's N-terminus with significantly improved pharmacokinetics

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Poly(2-methacryloyloxyethyl phosphorylcholine) for Protein Conjugation

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The effect of Fc glycan forms on human IgG2 antibody clearance in humans

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Protein therapeutics: a summary and pharmacological classification

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