Dynein at the kinetochore

Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congression

(2023) Jingchao Wu et al.   CURRENT BIOLOGY

Non-centrosomal microtubules at kinetochores promote rapid chromosome biorientation during mitosis in human cells

(2022) Fioranna Renda et al.   CURRENT BIOLOGY

Structure of the RZZ complex and molecular basis of Spindly‐driven corona assembly at human kinetochores

(2022) Tobias Raisch et al.   EMBO JOURNAL

JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport

(2022) Ricardo Celestino et al.   JOURNAL OF CELL BIOLOGY

Three-dimensional structure of kinetochore-fibers in human mitotic spindles

(2022) Robert Kiewisz et al.   eLife

The Four Causes: The Functional Architecture of Centromeres and Kinetochores

(2022) Andrew D. McAinsh et al.   Annual Review of Genetics

Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin

(2022) Ennio A. d’Amico et al.   JOURNAL OF CELL BIOLOGY

Lis1-dynein drives corona compaction and limits erroneous microtubule attachment at kinetochores

(2022) Olivera Mitevska et al.   JOURNAL OF CELL SCIENCE

Structure of dynein–dynactin on microtubules shows tandem adaptor binding

(2022) Sami Chaaban et al.   NATURE

The Disordered Spindly C-terminus Interacts with RZZ Subunits ROD-1 and ZWL-1 in the Kinetochore through the Same Sites in C. Elegans

(2021) Morkos A. Henen et al.   JOURNAL OF MOLECULAR BIOLOGY

Cryo‐EM reveals the complex architecture of dynactin's shoulder region and pointed end

(2021) Clinton K Lau et al.   EMBO JOURNAL

Dynein light intermediate chains as pivotal determinants of dynein multifunctionality

(2021) Amrita Kumari et al.   JOURNAL OF CELL SCIENCE

On and off controls within dynein–dynactin on native cargoes

(2021) Paulomi Sanghavi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spindle assembly checkpoint activation and silencing at kinetochores

(2021) Pablo Lara-Gonzalez et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Phosphorylation and Pin1 binding to the LIC1 subunit selectively regulate mitotic dynein functions

(2021) Amrita Kumari et al.   JOURNAL OF CELL BIOLOGY

Evolutionary Dynamics of the Spindle Assembly Checkpoint in Eukaryotes

(2020) Geert J.P.L. Kops et al.   CURRENT BIOLOGY

The Dynein Adaptor RILP Controls Neuronal Autophagosome Biogenesis, Transport, and Clearance

(2020) Noopur V. Khobrekar et al.   DEVELOPMENTAL CELL

Cyclin B1 scaffolds MAD 1 at the kinetochore corona to activate the mitotic checkpoint

(2020) Lindsey A Allan et al.   EMBO JOURNAL

CENP-F stabilizes kinetochore-microtubule attachments and limits dynein stripping of corona cargoes

(2020) Philip Auckland et al.   JOURNAL OF CELL BIOLOGY

Dynactin p150 promotes processive motility of DDB complexes by minimizing diffusional behavior of dynein

(2020) Qingzhou Feng et al.   MOLECULAR BIOLOGY OF THE CELL

LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes

(2020) Zaw Min Htet et al.   NATURE CELL BIOLOGY

Lis1 activates dynein motility by modulating its pairing with dynactin

(2020) Mohamed M. Elshenawy et al.   NATURE CELL BIOLOGY

Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity

(2020) Matthew G. Marzo et al.   NATURE CELL BIOLOGY

Crowning the Kinetochore: The Fibrous Corona in Chromosome Segregation

(2020) Geert J.P.L. Kops et al.   TRENDS IN CELL BIOLOGY

Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAA0528

(2019) Dail E. Chapman et al.   Nature Communications

A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport

(2019) Ricardo Celestino et al.   PLOS BIOLOGY

Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex

(2019) Gang Zhang et al.   EMBO JOURNAL

Spindle checkpoint silencing at kinetochores with submaximal microtubule occupancy

(2019) Banafsheh Etemad et al.   JOURNAL OF CELL SCIENCE

Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions

(2019) Laura Pirovano et al.   Nature Communications

Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner

(2019) Jonathan Kuhn et al.   JOURNAL OF CELL BIOLOGY

LIS1 regulates cargo-adapter–mediated activation of dynein by overcoming its autoinhibition in vivo

(2019) Rongde Qiu et al.   JOURNAL OF CELL BIOLOGY

Force-generating mechanisms of anaphase in human cells

(2019) Kruno Vukušić et al.   JOURNAL OF CELL SCIENCE

Polo regulates Spindly to prevent premature stabilization of kinetochore–microtubule attachments

(2019) João Barbosa et al.   EMBO JOURNAL

The kinetochore proteins CENP-E and CENP-F directly and specifically interact with distinct BUB mitotic checkpoint Ser/Thr kinases

(2018) Giuseppe Ciossani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antagonism between the dynein and Ndc80 complexes at kinetochores controls the stability of kinetochore–microtubule attachments during mitosis.

(2018) Mohammed A. Amin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microtubules assemble near most kinetochores during early prometaphase in human cells

(2018) Vitali Sikirzhytski et al.   JOURNAL OF CELL BIOLOGY

F-Actin nucleated on chromosomes coordinates their capture by microtubules in oocyte meiosis

(2018) Mariia Burdyniuk et al.   JOURNAL OF CELL BIOLOGY

Cdk1 phosphorylation of the dynein adapter Nde1 controls cargo binding from G2 to anaphase

(2018) Caitlin L. Wynne et al.   JOURNAL OF CELL BIOLOGY

The ESCRT protein Chmp4c regulates mitotic spindle checkpoint signaling

(2018) Eleni Petsalaki et al.   JOURNAL OF CELL BIOLOGY

Nde1 promotes diverse dynein functions through differential interactions and exhibits an isoform-specific proteasome association

(2018) Julie K. Monda et al.   MOLECULAR BIOLOGY OF THE CELL

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis

(2018) Carlos Sacristan et al.   NATURE CELL BIOLOGY

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity

(2018) In-Gyun Lee et al.   Nature Communications

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility

(2018) Danielle A. Grotjahn et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised

(2018) Jonne A. Raaijmakers et al.   Cell Reports

Dynein–Dynactin–NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble

(2018) Masako Okumura et al.   eLife

Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex

(2018) Thomas E Sladewski et al.   eLife

RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs

(2018) Mark A McClintock et al.   eLife

Bub1 is not essential for the checkpoint response to unattached kinetochores in diploid human cells

(2018) Cerys E. Currie et al.   CURRENT BIOLOGY

Cryo-EM shows how dynactin recruits two dyneins for faster movement

(2018) Linas Urnavicius et al.   NATURE

Distinct Roles of RZZ and Bub1-KNL1 in Mitotic Checkpoint Signaling and Kinetochore Expansion

(2018) Jose-Antonio Rodriguez-Rodriguez et al.   CURRENT BIOLOGY

Self-Assembly of the RZZ Complex into Filaments Drives Kinetochore Expansion in the Absence of Microtubule Attachment

(2018) Cláudia Pereira et al.   CURRENT BIOLOGY

BUB-1 promotes amphitelic chromosome biorientation via multiple activities at the kinetochore

(2018) Frances Edwards et al.   eLife

Molecular mechanism of dynein recruitment to kinetochores by the Rod–Zw10–Zwilch complex and Spindly

(2017) José B. Gama et al.   JOURNAL OF CELL BIOLOGY

Structure of the RZZ complex and molecular basis of its interaction with Spindly

(2017) Shyamal Mosalaganti et al.   JOURNAL OF CELL BIOLOGY

Spindle assembly checkpoint satisfaction occurs via end-on but not lateral attachments under tension

(2017) Jonathan Kuhn et al.   JOURNAL OF CELL BIOLOGY

Disease-associated mutations in human BICD2 hyperactivate motility of dynein–dynactin

(2017) Walter Huynh et al.   JOURNAL OF CELL BIOLOGY

NudE regulates dynein at kinetochores but is dispensable for other dynein functions in the C. elegans early embryo

(2017) Patrícia A. Simões et al.   JOURNAL OF CELL SCIENCE

DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis

(2017) Fei Ye et al.   NEURON

NuMA recruits dynein activity to microtubule minus-ends at mitosis

(2017) Christina L Hueschen et al.   eLife

Lissencephaly-1 is a context-dependent regulator of the human dynein complex

(2017) Janina Baumbach et al.   eLife

Tyrosination of α‐tubulin controls the initiation of processive dynein–dynactin motility

(2016) Richard J McKenney et al.   EMBO JOURNAL

Loss of CENP-F results in distinct microtubule-related defects without chromosomal abnormalities

(2016) Elise R. Pfaltzgraff et al.   MOLECULAR BIOLOGY OF THE CELL

Dynein Light Intermediate Chain 2 Facilitates the Metaphase to Anaphase Transition by Inactivating the Spindle Assembly Checkpoint

(2016) Sagar P. Mahale et al.   PLoS One

Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro

(2016) Babu J. N. Reddy et al.   Nature Communications

Structural basis for cargo binding and autoinhibition of Bicaudal-D1 by a parallel coiled-coil with homotypic registry

(2015) Shin-ichi Terawaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RZZ and Mad1 dynamics in Drosophila mitosis

(2015) Lénaïg Défachelles et al.   CHROMOSOME RESEARCH

KNL1-Bubs and RZZ Provide Two Separable Pathways for Checkpoint Activation at Human Kinetochores

(2015) Virginia Silió et al.   DEVELOPMENTAL CELL

A novel role of farnesylation in targeting a mitotic checkpoint protein, human Spindly, to kinetochores

(2015) Devinderjit K. Moudgil et al.   JOURNAL OF CELL BIOLOGY

Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors

(2015) Andrew J. Holland et al.   MOLECULAR BIOLOGY OF THE CELL

Adaptive changes in the kinetochore architecture facilitate proper spindle assembly

(2015) Valentin Magidson et al.   NATURE CELL BIOLOGY

Microtubule detyrosination guides chromosomes during mitosis

(2015) M. Barisic et al.   SCIENCE

The structure of the dynactin complex and its interaction with dynein

(2015) L. Urnavicius et al.   SCIENCE

Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint

(2015) Gang Zhang et al.   Nature Communications

The RZZ complex requires the N-terminus of KNL1 to mediate optimal Mad1 kinetochore localization in human cells

(2015) Gina V. Caldas et al.   Open Biology

In vitroreconstitution of a highly processive recombinant human dynein complex

(2014) Max A Schlager et al.   EMBO JOURNAL

Dynein-dependent transport of spindle assembly checkpoint proteins off kinetochores toward spindle poles

(2014) Patrícia M.A. Silva et al.   FEBS LETTERS

CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to kinetochore attachment status

(2014) Daniel R. Matson et al.   JOURNAL OF CELL BIOLOGY

Direct kinetochore–spindle pole connections are not required for chromosome segregation

(2014) Vitali Sikirzhytski et al.   JOURNAL OF CELL BIOLOGY

Force on spindle microtubule minus ends moves chromosomes

(2014) Mary Williard Elting et al.   JOURNAL OF CELL BIOLOGY

Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces

(2014) Marin Barisic et al.   NATURE CELL BIOLOGY

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes

(2014) R. J. McKenney et al.   SCIENCE

Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit

(2013) Ting-Yu Yeh et al.   EMBO JOURNAL

Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dynein

(2013) Y. Liu et al.   GENES & DEVELOPMENT

LIS1 controls mitosis and mitotic spindle organization via the LIS1–NDEL1–dynein complex

(2013) Hyang Mi Moon et al.   HUMAN MOLECULAR GENETICS

Spindle assembly checkpoint proteins are positioned close to core microtubule attachment sites at kinetochores

(2013) Dileep Varma et al.   JOURNAL OF CELL BIOLOGY

Systematic dissection of dynein regulators in mitosis

(2013) Jonne A. Raaijmakers et al.   JOURNAL OF CELL BIOLOGY

Nudel/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis

(2013) Shusheng Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Crosstalk Between Microtubule Attachment Complexes Ensures Accurate Chromosome Segregation

(2013) D. K. Cheerambathur et al.   SCIENCE

The Spatial Arrangement of Chromosomes during Prometaphase Facilitates Spindle Assembly

(2011) Valentin Magidson et al.   CELL

Polo-like Kinase1 Is Required for Recruitment of Dynein to Kinetochores during Mitosis

(2011) Jason R. Bader et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutually Exclusive Cytoplasmic Dynein Regulation by NudE-Lis1 and Dynactin

(2011) Richard J. McKenney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N-terminal coiled-coil of Ndel1 is a regulated scaffold that recruits LIS1 to dynein

(2011) Eliza Żyłkiewicz et al.   JOURNAL OF CELL BIOLOGY

A Nup133-dependent NPC-anchored network tethers centrosomes to the nuclear envelope in prophase

(2011) Stéphanie Bolhy et al.   JOURNAL OF CELL BIOLOGY

Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores

(2011) James M. Kasuboski et al.   MOLECULAR BIOLOGY OF THE CELL

Dynein/Dynactin-Mediated Transport of Kinetochore Components off Kinetochores and onto Spindle Poles Induced by Nordihydroguaiaretic Acid

(2011) Jakub K. Famulski et al.   PLoS One

LIS1 and NudE Induce a Persistent Dynein Force-Producing State

(2010) Richard J. McKenney et al.   CELL

Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells

(2010) R. Gassmann et al.   GENES & DEVELOPMENT

Identification of a Novel Dynein Binding Domain in Nudel Essential for Spindle Pole Organization inXenopusEgg Extract

(2010) Shusheng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning

(2010) C. Lam et al.   JOURNAL OF CELL SCIENCE

Spindly/CCDC99 Is Required for Efficient Chromosome Congression and Mitotic Checkpoint Regulation

(2010) Marin Barisic et al.   MOLECULAR BIOLOGY OF THE CELL

Structural Analysis of the RZZ Complex Reveals Common Ancestry with Multisubunit Vesicle Tethering Machinery

(2010) Filiz Çivril et al.   STRUCTURE

Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint

(2009) Mylavarapu V S Sivaram et al.   EMBO JOURNAL

Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly

(2009) Ying Wai Chan et al.   JOURNAL OF CELL BIOLOGY

Roles of the Drosophila NudE protein in kinetochore function and centrosome migration

(2009) A. Wainman et al.   JOURNAL OF CELL SCIENCE

Chromosome congression in the absence of kinetochore fibres

(2009) Shang Cai et al.   NATURE CELL BIOLOGY

A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex

(2008) R. Gassmann et al.   GENES & DEVELOPMENT

N-terminal region of ZW10 serves not only as a determinant for localization but also as a link with dynein function

(2008) Mamiko Inoue et al.   GENES TO CELLS

Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis

(2008) Jacqueline Whyte et al.   JOURNAL OF CELL BIOLOGY

Direct role of dynein motor in stable kinetochore-microtubule attachment, orientation, and alignment

(2008) Dileep Varma et al.   JOURNAL OF CELL BIOLOGY

Dynein Light Intermediate Chain: An Essential Subunit That Contributes to Spindle Checkpoint Inactivation

(2008) Sarah Mische et al.   MOLECULAR BIOLOGY OF THE CELL