Bioisosteric modification of Linezolid identified the potential M. tuberculosis protein synthesis inhibitors to overcome the myelosuppression and serotonergic toxicity associated with Linezolid in the treatment of the multi-drug resistance tuberculosis (MDR-TB)

Structural exploration of selected C6 and C7-substituted coumarin isomers as selective MAO-B inhibitors

(2022) Yassir Boulaamane et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Molecular modelling and structure-activity relationship of a natural derivative of o-hydroxybenzoate as a potent inhibitor of dual NSP3 and NSP12 of SARS-CoV-2: in silico study

(2022) Yusuf Oloruntoyin Ayipo et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Design, synthesis, molecular docking and molecular dynamics studies of novel triazolothiadiazine derivatives containing furan or thiophene rings as anticancer agents

(2022) Derya Osmaniye et al.   BIOORGANIC CHEMISTRY

Optimizing cardio, hepato and phospholipidosis toxicity of the Bedaquiline by chemoinformatics and molecular modelling approach

(2022) R. Girase et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

Potent Bioactive Compounds From Seaweed Waste to Combat Cancer Through Bioinformatics Investigation

(2022) Kaushik Kumar Bharadwaj et al.   Frontiers in Nutrition

Phytochemicals from Amberboa ramosa as potential DPP-IV inhibitors for the management of Type-II diabetes mellitus: Inferences from in-silico investigations

(2022) Rakesh Kumar Paul et al.   JOURNAL OF MOLECULAR STRUCTURE

Computational investigation of phytochemicals from Withania somnifera (Indian ginseng/ashwagandha) as plausible inhibitors of GluN2B-containing NMDA receptors

(2021) Iqrar Ahmad et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Synthesis, molecular docking, DFT study, and in vitro antimicrobial activity of some 4‐(biphenyl‐4‐yl)‐1,4‐dihydropyridine and 4‐(biphenyl‐4‐yl)pyridine derivatives

(2021) Alimamad Malani et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Tomatidine and Patchouli Alcohol as Inhibitors of SARS-CoV-2 Enzymes (3CLpro, PLpro and NSP15) by Molecular Docking and Molecular Dynamics Simulations

(2021) Rafat Zrieq et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SwissBioisostere 2021: updated structural, bioactivity and physicochemical data delivered by a reshaped web interface

(2021) Alessandro Cuozzo et al.   NUCLEIC ACIDS RESEARCH

Synthesis, molecular modelling study of the methaqualone analogues as anti-convulsant agent with improved cognition activity and minimized neurotoxicity

(2021) Iqrar Ahmad et al.   JOURNAL OF MOLECULAR STRUCTURE

Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis

(2020) Hongyi Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigating the Impact of Different Acrylamide (Electrophilic Warhead) on Osimertinib’s Pharmacological Spectrum by Molecular Mechanic and Quantum Mechanic Approach

(2020) Harun Patel et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Electrostatic Complementarity as a Fast and Effective Tool to Optimize Binding and Selectivity of Protein–Ligand Complexes

(2019) Matthias R. Bauer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyridine and nitro-phenyl linked 1,3,4-thiadiazoles as MDR-TB inhibitors

(2019) Harun Patel et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Practical High-Quality Electrostatic Potential Surfaces for Drug Discovery Using a Graph-Convolutional Deep Neural Network

(2019) Prakash Chandra Rathi et al.   JOURNAL OF MEDICINAL CHEMISTRY

An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria

(2016) Amit Kaushik et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Linezolid in the treatment of drug-resistant tuberculosis: the challenge of its narrow therapeutic index

(2016) Sean Wasserman et al.   Expert Review of Anti-Infective Therapy

Linezolid Induced Adverse Drug Reactions - An Update

(2015) Kamal Kishor et al.   CURRENT DRUG METABOLISM

SwissBioisostere: a database of molecular replacements for ligand design

(2012) Matthias Wirth et al.   NUCLEIC ACIDS RESEARCH

Linezolid, the first oxazolidinone antibacterial agent

(2011) Karen L. Leach et al.   Annals of the New York Academy of Sciences

In Vitro and In Vivo Activities of LCB01-0371, a New Oxazolidinone

(2010) J.-W. Jeong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibacterial oxazolidinones: emerging structure–toxicity relationships

(2010) Adam R Renslo   Expert Review of Anti-Infective Therapy

Linezolid in the Treatment of Multidrug‐Resistant Tuberculosis

(2009) G. F. Schecter et al.   CLINICAL INFECTIOUS DISEASES

Zyvox® Annual Appraisal of Potency and Spectrum program: linezolid surveillance program results for 2008

(2009) Ronald N. Jones et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Early and Extended Early Bactericidal Activity of Linezolid in Pulmonary Tuberculosis

(2008) Reynaldo Dietze et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

New oxazolidinone derivatives as antibacterial agents with improved activity

(2008) Giovanna Poce et al.   EXPERT OPINION ON THERAPEUTIC PATENTS