The Alzheimer’s Disease Mitochondrial Cascade Hypothesis: A Current Overview

In vivo mitochondrial and glycolytic impairments in patients with Alzheimer disease

(2020) Tatsuhiro Terada et al.   NEUROLOGY

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

(2020) Erik C. B. Johnson et al.   NATURE MEDICINE

Safety and target engagement profile of two oxaloacetate doses in Alzheimer's patients

(2020) Eric D. Vidoni et al.   Alzheimers & Dementia

Exploratory analysis of mtDNA haplogroups in two Alzheimer's longitudinal cohorts

(2020) Russell H. Swerdlow et al.   Alzheimers & Dementia

Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis

(2020) Ian W. Weidling et al.   EXPERIMENTAL NEUROLOGY

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Preliminary Report on the Feasibility and Efficacy of the Modified Atkins Diet for Treatment of Mild Cognitive Impairment and Early Alzheimer’s Disease

(2019) Jason Brandt et al.   JOURNAL OF ALZHEIMERS DISEASE

PTCD1 is required for mitochondrial oxidative-phosphorylation: possible genetic association with Alzheimer's disease

(2019) Daniel Fleck et al.   JOURNAL OF NEUROSCIENCE

TOMM40 ‘523 Associations with Baseline and Longitudinal Cognition in APOE ɛ3 Homozygotes

(2019) Amber Watts et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitonuclear interactions influence Alzheimer’s disease risk

(2019) Shea J. Andrews et al.   NEUROBIOLOGY OF AGING

Modified Ketogenic Diet Is Associated With Improved Cerebrospinal Fluid Biomarker Profile, Cerebral Perfusion, And Cerebral Ketone Body Uptake In Older Adults At-Risk For Alzheimer’s Disease: A Pilot Study

(2019) Bryan J. Neth et al.   NEUROBIOLOGY OF AGING

Mitochondria and Alzheimer’s: Is PTCD1 the Smoking Gun?

(2019) Judy Pa et al.   TRENDS IN NEUROSCIENCES

Brain clusterin protein isoforms and mitochondrial localization

(2019) Sarah K Herring et al.   eLife

Assembly of 809 whole mitochondrial genomes with clinical, imaging, and fluid biomarker phenotyping

(2018) Perry G. Ridge et al.   Alzheimers & Dementia

Evidence for brain glucose dysregulation in Alzheimer's disease

(2018) Yang An et al.   Alzheimers & Dementia

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease

(2018) Russell H. Swerdlow   JOURNAL OF ALZHEIMERS DISEASE

Sex differences in Alzheimer disease — the gateway to precision medicine

(2018) Maria Teresa Ferretti et al.   Nature Reviews Neurology

Long-term Effects of Galantamine Treatment on Brain Functional Activities as Measured by PET in Alzheimer's Disease Patients

(2018) Connor Keller et al.   JOURNAL OF ALZHEIMERS DISEASE

Reduced Mitochondria Cytochrome Oxidase Activity in Adult Children of Mothers with Alzheimer's Disease

(2018) Lisa Mosconi et al.   JOURNAL OF ALZHEIMERS DISEASE

The Impact of Mitochondrial and Nuclear DNA Variants on Late-Onset Alzheimer's Disease Risk

(2018) Aleksandra Maruszak et al.   JOURNAL OF ALZHEIMERS DISEASE

Effect of Cholinergic Signaling on Neuronal Cell Bioenergetics

(2018) Jianghua Lu et al.   JOURNAL OF ALZHEIMERS DISEASE

A Mitochondrial Biomarker-Based Study of S-Equol in Alzheimer’s Disease Subjects: Results of a Single-Arm, Pilot Trial

(2017) Heather M. Wilkins et al.   JOURNAL OF ALZHEIMERS DISEASE

Cytosolic proteostasis through importing of misfolded proteins into mitochondria

(2017) Linhao Ruan et al.   NATURE

TOMM40 ′523 variant and cognitive decline in older persons with APOE ε3/3 genotype

(2017) Lei Yu et al.   NEUROLOGY

Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders?

(2017) Jack van Horssen et al.   NEUROSCIENCE LETTERS

ATP as a biological hydrotrope

(2017) Avinash Patel et al.   SCIENCE

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Platelet cytochrome oxidase and citrate synthase activities in APOE ε4 carrier and non-carrier Alzheimer's disease patients

(2017) Heather M. Wilkins et al.   Redox Biology

The Alzheimer's Disease Mitochondrial Cascade Hypothesis

(2017) Russell H. Swerdlow et al.   JOURNAL OF ALZHEIMERS DISEASE

Systemic Mitochondrial Dysfunction and the Etiology of Alzheimer's Disease and Down Syndrome Dementia

(2017) Pinar E. Coskun et al.   JOURNAL OF ALZHEIMERS DISEASE

Reduced Posterior Cingulate Mitochondrial Activity in Expired Young Adult Carriers of the APOE ε4 Allele, the Major Late-Onset Alzheimer's Susceptibility Gene

(2017) Jon Valla et al.   JOURNAL OF ALZHEIMERS DISEASE

Antioxidants Rescue Mitochondrial Transport in Differentiated Alzheimer’s Disease Trans-Mitochondrial Cybrid Cells

(2016) Qing Yu et al.   JOURNAL OF ALZHEIMERS DISEASE

Chronic consumption ofAnnona muricatajuice triggers and aggravates cerebral tau phosphorylation in wild-type andMAPTtransgenic mice

(2016) Robert Rottscholl et al.   JOURNAL OF NEUROCHEMISTRY

Extracellular Mitochondria and Mitochondrial Components Act as Damage-Associated Molecular Pattern Molecules in the Mouse Brain

(2016) Heather M. Wilkins et al.   Journal of Neuroimmune Pharmacology

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

(2016) Matthew R. Brier et al.   Science Translational Medicine

Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

(2016) Sama F Sleiman et al.   eLife

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

Dose-specific effect of simvastatin on hypoxia-induced HIF-1α and BACE expression in Alzheimer’s disease cybrid cells

(2015) Jin-Heon Jeong et al.   BMC Neurology

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease

(2015) Kaoru Yamamoto et al.   Cell Reports

Role of diffuse low-level heteroplasmy of mitochondrial DNA in Alzheimer’s disease neurodegeneration

(2015) Tiziana Casoli et al.   Frontiers in Aging Neuroscience

Hypoxia-Inducible Factor-1 in Physiological and Pathophysiological Angiogenesis: Applications and Therapies

(2015) Agnieszka Zimna et al.   Biomed Research International

White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease

(2015) Lauren P. Klosinski et al.   EBioMedicine

Is Alzheimer's disease a systemic disease?

(2014) Jill K. Morris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice

(2014) Elizabeth S. Yamada et al.   EXPERIMENTAL NEUROLOGY

PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease

(2014) Magali Dumont et al.   FASEB JOURNAL

Oxidative stress-mediated activation of extracellular signal-regulated kinase contributes to mild cognitive impairment-related mitochondrial dysfunction

(2014) Xueqi Gan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer’s disease

(2014) Jee Hoon Roh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer’s disease

(2014) Lokesh Kukreja et al.   Molecular Neurodegeneration

Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation

(2014) Lezi E et al.   NEUROBIOLOGY OF AGING

Piericidin A Aggravates Tau Pathology in P301S Transgenic Mice

(2014) Matthias Höllerhage et al.   PLoS One

Contribution of non-reference alleles in mtDNA of Alzheimer's disease patients

(2014) Tiziana Casoli et al.   Annals of Clinical and Translational Neurology

Glycolysis–respiration relationships in a neuroblastoma cell line

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell

(2013) Xueqi Gan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Bioenergetic medicine

(2013) Russell H Swerdlow   BRITISH JOURNAL OF PHARMACOLOGY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Prodromal Metabolic Phenotype in MCI Cybrids: Implications for Alzheimer’s Disease

(2013) D. F. Silva et al.   Current Alzheimer Research

Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines

(2013) D. F. Silva et al.   HUMAN MOLECULAR GENETICS

Lactate administration reproduces specific brain and liver exercise-related changes

(2013) Lezi E et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial DNA damage in a mouse model of Alzheimer's disease decreases amyloid beta plaque formation

(2013) Milena Pinto et al.   NEUROBIOLOGY OF AGING

Mitochondrial DNA polymorphisms specifically modify cerebral β-amyloid proteostasis

(2012) Katja Scheffler et al.   ACTA NEUROPATHOLOGICA

Longitudinal modeling of cognitive aging and the TOMM40 effect

(2012) Richard J. Caselli et al.   Alzheimers & Dementia

National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

(2012) Bradley T. Hyman et al.   Alzheimers & Dementia

A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging

(2012) Kathleen M. Hayden et al.   Alzheimers & Dementia

TOMM40 intron 6 poly-T length, age at onset, and neuropathology of AD in individuals with APOE ɛ3/ɛ3

(2012) Ge Li et al.   Alzheimers & Dementia

Cerebral Blood Flow is Diminished in Asymptomatic Middle-Aged Adults with Maternal History of Alzheimer's Disease

(2012) Ozioma C. Okonkwo et al.   CEREBRAL CORTEX

Mitochondria-associated ER membranes in Alzheimer disease

(2012) Eric A. Schon et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Cognitively normal individuals with AD parents may be at risk for developing aging-related cortical thinning patterns characteristic of AD

(2012) Katherine Reiter et al.   NEUROIMAGE

From system to organ to cell: oxygenation and perfusion measurement in anesthesia and critical care

(2012) Patrick Schober et al.   JOURNAL OF CLINICAL MONITORING AND COMPUTING

The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ɛ3/ɛ3 genotype

(2011) Sterling C. Johnson et al.   Alzheimers & Dementia

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Mitochondria and Cell Bioenergetics: Increasingly Recognized Components and a Possible Etiologic Cause of Alzheimer's Disease

(2011) Russell H. Swerdlow   ANTIOXIDANTS & REDOX SIGNALING

The Mitochondrial Cascade Hypothesis for Parkinsons Disease

(2011) Sandra M. Cardoso   CURRENT PHARMACEUTICAL DESIGN

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease

(2011) Baiyang Sheng et al.   JOURNAL OF NEUROCHEMISTRY

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

Structural brain changes in normal individuals with a maternal history of Alzheimer's

(2011) Valentina Berti et al.   NEUROBIOLOGY OF AGING

Amyloid β-induced ER stress is enhanced under mitochondrial dysfunction conditions

(2011) Rui O. Costa et al.   NEUROBIOLOGY OF AGING

Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer's disease

(2011) Kim J. Krishnan et al.   NEUROBIOLOGY OF AGING

Progressive regional atrophy in normal adults with a maternal history of Alzheimer disease

(2011) R. A. Honea et al.   NEUROLOGY

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Defects in amphiphysin 2 (BIN1) and triads in several forms of centronuclear myopathies

(2010) Anne Toussaint et al.   ACTA NEUROPATHOLOGICA

An Inherited Variable Poly-T Repeat Genotype in TOMM40 in Alzheimer Disease

(2010) Allen D. Roses   ARCHIVES OF NEUROLOGY

Oxidative Stress and Amyloid-Beta Pathology in Normal Individuals with A Maternal History of Alzheimer's

(2010) Lisa Mosconi et al.   BIOLOGICAL PSYCHIATRY

The Role of Mitochondria in the Pathogenesis of Type 2 Diabetes

(2010) Mary-Elizabeth Patti et al.   ENDOCRINE REVIEWS

Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways

(2010) Haiying Zhang et al.   EXPERIMENTAL GERONTOLOGY

Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease

(2010) Hung-Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models

(2010) Roman Chrast et al.   JOURNAL OF LIPID RESEARCH

Nerve growth factor attenuates oxidant-induced β-amyloid neurotoxicity in sporadic Alzheimer’s disease cybrids

(2010) Isaac G. Onyango et al.   JOURNAL OF NEUROCHEMISTRY

Tissue-specific differences in mitochondrial activity and biogenesis

(2010) Erika Fernández-Vizarra et al.   MITOCHONDRION

Effects of ApoE4 and maternal history of dementia on hippocampal atrophy

(2010) John P. Andrawis et al.   NEUROBIOLOGY OF AGING

Dietary ketosis enhances memory in mild cognitive impairment

(2010) Robert Krikorian et al.   NEUROBIOLOGY OF AGING

Reduced gray matter volume in normal adults with a maternal family history of Alzheimer disease

(2010) R. A. Honea et al.   NEUROLOGY

Increased fibrillar amyloid-  burden in normal individuals with a family history of late-onset Alzheimer's

(2010) L. Mosconi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Donepezil- and scopolamine-induced rCMRglu changes assessed by PET in conscious rhesus monkeys

(2009) Makoto Asai et al.   ANNALS OF NUCLEAR MEDICINE

PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia

(2009) Weiping Qin et al.   ARCHIVES OF NEUROLOGY

The Alzheimer's disease mitochondrial cascade hypothesis: An update

(2009) Russell H. Swerdlow et al.   EXPERIMENTAL NEUROLOGY

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Association of parental dementia with cognitive and brain MRI measures in middle-aged adults

(2009) S. Debette et al.   NEUROLOGY

Age, Neuropathology, and Dementia

(2009) George M. Savva et al.   NEW ENGLAND JOURNAL OF MEDICINE

A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease

(2009) A D Roses et al.   PHARMACOGENOMICS JOURNAL

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE

Influence of mitochondrial DNA level on cellular energy metabolism: implications for mitochondrial diseases

(2008) Christophe Rocher et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Prevalence of dementia after age 90: Results from The 90+ Study

(2008) M. M. Corrada et al.   NEUROLOGY

Amyloid-  Dynamics Correlate with Neurological Status in the Injured Human Brain

(2008) D. L. Brody et al.   SCIENCE