Regulation of Adenine Nucleotide Metabolism by Adenylate Kinase Isozymes: Physiological Roles and Diseases

Adenylate kinase 1 overexpression increases locomotor activity in medaka fish

(2022) Michiyo Maruyama et al.   PLoS One

Red cell adenylate kinase deficiency in China: molecular study of 2 new mutations (413G > A, 223dupA)

(2022) Sijia He et al.   BMC Medical Genomics

Adenylate Kinase Isozyme 3 Regulates Mitochondrial Energy Metabolism and Knockout Alters HeLa Cell Metabolism

(2022) Koichi Fujisawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AK4P1 is a cancer‑promoting pseudogene in pancreatic adenocarcinoma cells whose transcripts can be transmitted by exosomes

(2022) Ling Li et al.   Oncology Letters

Adenylate kinase AK2 isoform integral in embryo and adult heart homeostasis

(2021) Song Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of novel cell glycolysis related gene signature predicting survival in patients with breast cancer

(2021) Feng Jiang et al.   Scientific Reports

Distinctive clinical presentation and pathogenic specificities of anti-AK5 encephalitis

(2021) Sergio Muñiz-Castrillo et al.   BRAIN

Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression

(2021) Ruidan Xu et al.   FEBS LETTERS

Identification of novel DNA hypermethylation of the adenylate kinase 5 promoter in colorectal adenocarcinoma

(2021) Bokyung Ahn et al.   Scientific Reports

AK2 Promotes the Migration and Invasion of Lung Adenocarcinoma by Activating TGF-β/Smad Pathway In vitro and In vivo

(2021) Fangfang Cai et al.   Frontiers in Pharmacology

Adenylate Kinase 4—A Key Regulator of Proliferation and Metabolic Shift in Human Pulmonary Arterial Smooth Muscle Cells via Akt and HIF-1α Signaling Pathways

(2021) Magdalena Wujak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel homozygous missense mutation in AK7 causes multiple morphological anomalies of the flagella and oligoasthenoteratozoospermia

(2021) Mingfei Xiang et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Emerging Potential of Exosomes in Regenerative Medicine for Temporomandibular Joint Osteoarthritis

(2020) Yeon-Hee Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosome‐delivered circRNA promotes glycolysis to induce chemoresistance through the miR‐122‐PKM2 axis in colorectal cancer

(2020) Xinyi Wang et al.   Molecular Oncology

MiR-96-5p promotes breast cancer migration by activating MEK/ERK signaling

(2020) Wei-yan Qin et al.   JOURNAL OF GENE MEDICINE

Adenylate Kinase and Metabolic Signaling in Cancer Cells

(2020) Aleksandr Klepinin et al.   Frontiers in Oncology

Adenylate kinase 1 deficiency disrupts mouse sperm motility under conditions of energy stress

(2020) Minyu Xie et al.   BIOLOGY OF REPRODUCTION

hCINAP is a potential direct HIF-1 target gene and is required for hypoxia-induced EMT and apoptosis in cervical cancer cells

(2020) yong zhang et al.   Biochemistry and Cell Biology

Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m6A-Based Epitranscriptomic Mechanism

(2020) Xiaochuan Liu et al.   MOLECULAR THERAPY

Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis

(2019) Yi-Hua Jan et al.   Journal of Hematology & Oncology

Adenylate kinase 4 promotes bladder cancer cell proliferation and invasion

(2019) Feng Xin et al.   CLINICAL AND EXPERIMENTAL MEDICINE

A model for reticular dysgenesis shows impaired sensory organ development and hair cell regeneration linked to cellular stress

(2019) Alberto Rissone et al.   Disease Models & Mechanisms

Prognostic and therapeutic potential of Adenylate kinase 2 in lung adenocarcinoma

(2019) Huibin Liu et al.   Scientific Reports

Mitochondrial Activity and Unfolded Protein Response are Required for Neutrophil Differentiation

(2018) Ayako Tanimura et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Homozygous missense mutation L673P in adenylate kinase 7 (AK7) leads to primary male infertility and multiple morphological anomalies of the flagella but not to primary ciliary dyskinesia

(2018) Patrick Lorès et al.   HUMAN MOLECULAR GENETICS

Proteomic Analysis of Neuroblastoma-Derived Exosomes: New Insights into a Metastatic Signature

(2017) Marta Colletti et al.   PROTEOMICS

Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation

(2017) Yapeng Ji et al.   Nature Communications

Limb girdle myasthenia with digenic RAPSN and a novel disease gene AK9 mutations

(2016) Ching-Wan Lam et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Modulation of anti-cancer drug sensitivity through the regulation of mitochondrial activity by adenylate kinase 4

(2016) Koichi Fujisawa et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth

(2016) Dongmei Bai et al.   Nature Communications

Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs

(2015) Mian He et al.   CARCINOGENESIS

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

(2015) Anoek Zomer et al.   CELL

Reticular dysgenesis–associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress

(2015) Alberto Rissone et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adenine Nucleotide Metabolism and a Role for AMP in Modulating Flagellar Waveforms in Mouse Sperm1

(2014) Melissa L. Vadnais et al.   BIOLOGY OF REPRODUCTION

The many isoforms of human adenylate kinases

(2014) Christakis Panayiotou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets

(2014) Annika Pienimaeki-Roemer et al.   TRANSFUSION

The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth

(2014) Hyunjoo Kim et al.   Nature Communications

A Mitochondrial RNAi Screen Defines Cellular Bioenergetic Determinants and Identifies an Adenylate Kinase as a Key Regulator of ATP Levels

(2014) Nathan J. Lanning et al.   Cell Reports

Differential expression of adenylate kinase 4 in the context of disparate stress response strategies of HEK293 and HepG2 cells

(2013) Fanzhi Kong et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase

(2013) Marjan Amiri et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Characterization and proteomic analysis of ovarian cancer-derived exosomes

(2013) Bing Liang et al.   Journal of Proteomics

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

(2013) Marco Prunotto et al.   Journal of Proteomics

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

(2013) Fatih Arslan et al.   Stem Cell Research

New Adenylate Kinase 7 (AK7) Mutation in Primary Ciliary Dyskinesia

(2012) Manuel Mata et al.   American Journal of Rhinology & Allergy

Adenylate kinase 2 (AK2) promotes cell proliferation in insect development

(2012) Ru-Ping Chen et al.   BMC MOLECULAR BIOLOGY

Adenylate Kinase-4 Is a Marker of Poor Clinical Outcomes That Promotes Metastasis of Lung Cancer by Downregulating the Transcription Factor ATF3

(2012) Y.-H. Jan et al.   CANCER RESEARCH

A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes

(2012) Delfin A.A. Raj et al.   KIDNEY INTERNATIONAL

Two Distinct Populations of Exosomes Are Released from LIM1863 Colon Carcinoma Cell-derived Organoids

(2012) Bow J. Tauro et al.   MOLECULAR & CELLULAR PROTEOMICS

Rhythmic Nucleotide Synthesis in the Liver: Temporal Segregation of Metabolites

(2012) Jean-Michel Fustin et al.   Cell Reports

Exosomes as intercellular signalosomes and pharmacological effectors

(2011) Michel Record et al.   BIOCHEMICAL PHARMACOLOGY

Identification of a novel nuclear-localized adenylate kinase from Drosophila melanogaster

(2011) Geng Meng et al.   BIOCHEMISTRY-MOSCOW

Crosstalk between Components of Circadian and Metabolic Cycles in Mammals

(2011) Gad Asher et al.   Cell Metabolism

Expression of PTRF in PC-3 Cells Modulates Cholesterol Dynamics and the Actin Cytoskeleton Impacting Secretion Pathways

(2011) Kerry L. Inder et al.   MOLECULAR & CELLULAR PROTEOMICS

The role of clock genes and rhythmicity in the liver

(2011) I. Schmutz et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Circadian rhythms: Redox redux

(2011) Joseph Bass et al.   NATURE

Adenylate Kinase 3 Sensitizes Cells to Cigarette Smoke Condensate Vapor Induced Cisplatin Resistance

(2011) Xiaofei Chang et al.   PLoS One

Congenital Hydrocephalus in Genetically Engineered Mice

(2011) P. Vogel et al.   VETERINARY PATHOLOGY

Role of Adenylate Kinase Type 7 Expression on Cilia Motility: Possible Link in Primary Ciliary Dyskinesia

(2010) Javier Milara et al.   American Journal of Rhinology & Allergy

The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes

(2010) Christakis Panayiotou et al.   BIOCHEMICAL JOURNAL

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

(2010) Sonja I Buschow et al.   IMMUNOLOGY AND CELL BIOLOGY

Adenylate Kinase 2 Links Mitochondrial Energy Metabolism to the Induction of the Unfolded Protein Response

(2010) Alison Burkart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecules in motion: influences of diffusion on metabolic structure and function in skeletal muscle

(2010) S. T. Kinsey et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes

(2010) Jung Eun Park et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification of genes selectively disallowed in the pancreatic islet

(2010) Timothy J. Pullen et al.   Islets

Localization of Adenylate Kinase 4 in Mouse Tissues

(2009) Keiko Miyoshi et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

Identification of two active functional domains of human adenylate kinase 5

(2009) Nicola Solaroli et al.   FEBS LETTERS

Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury

(2009) S. Bruno et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation

(2009) K. A. Lamia et al.   SCIENCE

Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?

(2008) Mehmet Kesimer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mutation of Murine Adenylate Kinase 7 Underlies a Primary Ciliary Dyskinesia Phenotype

(2008) Angeles Fernandez-Gonzalez et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase

(2008) Rujuan Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Large-Scale Proteomics and Phosphoproteomics of Urinary Exosomes

(2008) P. A. Gonzales et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness

(2008) Chantal Lagresle-Peyrou et al.   NATURE GENETICS

Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2

(2008) Ulrich Pannicke et al.   NATURE GENETICS