Article
Oncology
Dai Zhang, Yi Zheng, Si Yang, Yiche Li, Meng Wang, Jia Yao, Yujiao Deng, Na Li, Bajin Wei, Ying Wu, Yuyao Zhu, Hongtao Li, Zhijun Dai
Summary: This study developed an 11-gene signature related to glycolysis for predicting survival in patients with breast cancer, which showed good prognostic ability independent of clinical features. The findings provide insights into identifying breast cancer patients with a poor prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Menglin He, Cheng Hu, Jian Deng, Hui Ji, Weiqian Tian
Summary: We developed a novel six-gene signature related to glycolysis to predict the survival of patients with breast cancer. This signature was able to accurately predict patient outcomes and independent of clinical factors. The expression levels of the six biomarkers in breast cancer tissues were higher than in normal tissues, indicating their potential as prognostic markers.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Medical Laboratory Technology
Ang Li, Sinan Hou, Jian Chen, Yanfang Jiang
Summary: This study developed a novel risk signature for predicting the survival of patients with pancreatic adenocarcinoma, involving three genes (KIF20A, CHST2, and MET) significantly associated with overall survival. Using a large cohort and multivariate Cox regression analysis, the study confirmed the independent prognostic value of this signature.
CLINICA CHIMICA ACTA
(2021)
Article
Immunology
Shuning Ding, Xi Sun, Li Zhu, Yafen Li, Weiguo Chen, Kunwei Shen
Summary: In this study, a four-gene signature based on immune-related genes was developed for prognostic prediction in breast cancer. The results showed that patients in the low-risk group had significantly better overall survival compared to those in the high-risk group. The immune-related prognostic signature (IRPS) was found to be an independent predictor of patient survival and when combined with clinical factors, showed good predictive performance.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Ziming Xu, Shiwei Zhang, Fulai Nian, Shangyu Xu
Summary: This study developed a glycolysis-related gene signature to predict patients' survival with LUSC and explore new therapeutic targets. The model can divide patients into high- and low-risk groups, showing significant differences in overall survival, and providing new biomarkers for targeted therapy in LUSC patients.
Article
Cell Biology
Mengkai Yang, Xiaojun Ma, Zhuoying Wang, Tao Zhang, Yingqi Hua, Zhengdong Cai
Summary: The study established a novel glycolysis-related risk signature that could predict the prognosis of patients with osteosarcoma, with patients in the high-risk group showing poor outcomes. Additionally, the low-risk group exhibited higher immune scores and immune infiltration levels compared to the high-risk group.
Article
Oncology
Jing Yu, Ting-Ting Liu, Lei-Lei Liang, Jing Liu, Hong-Qing Cai, Jia Zeng, Tian-Tian Wang, Jian Li, Lin Xiu, Ning Li, Ling-Ying Wu
Summary: A novel risk signature incorporating five glycolysis-related genes was identified to effectively assess the prognosis and guide the treatment of OC patients. This signature was associated with KEGG pathways related to axon guidance, mTOR signalling, tight junctions, etc., and could accurately predict survival rate. Lower expression levels of ISG20 and SEH1L in tumor tissues compared to normal tissues were observed, and overexpression of ISG20 or SEH1L inhibited proliferation, migration, invasion in vitro, and tumor growth in vivo.
CANCER CELL INTERNATIONAL
(2021)
Article
Genetics & Heredity
Zhenming Zheng, Cong Lai, Wenshuang Li, Caixia Zhang, Kaiqun Ma, Yousheng Yao
Summary: A novel prognostic prediction model for BCa was established based on 9 glycolysis-related lncRNAs, effectively distinguishing high-risk and low-risk BCa patients, providing a new point of reference for clinicians to make individualized treatment and review plans for patients with different levels of risk.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Junjie Kong, Guangsheng Yu, Wei Si, Guangbing Li, Jiawei Chai, Yong Liu, Jun Liu
Summary: We identified five glycolysis-related genes (GRGs) associated with hepatocellular carcinoma (HCC) prognosis and constructed two gene signatures related to overall survival (OS) and disease-free survival (DFS) in HCC. The findings of this study may contribute to prognosis prediction and advancement in HCC treatment.
Article
Oncology
Tian-cheng Cheng, Jia-hao Wu, Bei Zhu, Hai-yan Gao, Lin Zheng, Wei-xian Chen
Summary: In this study, a five-gene signature including BCL2, SLC40A1, TFF1, APOOL, and PRAME was established for prognostic prediction in breast cancer. The signature showed good performance in survival prediction and was associated with cancer progression, immune infiltration, immune response, and drug resistance.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Genetics & Heredity
Xiaolu Zhang, Jia Wang, Jing Zhuang, Cun Liu, Chundi Gao, Huayao Li, Xiaoran Ma, Jie Li, Changgang Sun
Summary: By studying glycolysis-related genes, we established a four-gene breast cancer prediction signature that includes PGK1, SDHC, PFKL, and NUP43. This signature can help assess patients' risk and guide personalized treatment.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Xuejing Shi, Baoqiang Xiao, Rui Feng
Summary: In this study, mRNA and miRNA expression profiles of breast cancer patients were collected to explore a novel prognostic strategy using bioinformatics tools. Six glycolysis-related miRNAs were found to be correlated with prognosis of breast cancer. The established risk score model based on these miRNAs effectively predicted the prognosis of breast cancer patients, with the high risk group having significantly poorer outcomes.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Oncology
Yuxia Ruan, Qiang Tang, Jianghua Qiao, Jiabin Wang, Huimin Li, Xiayu Yue, Yadong Sun, Peili Wang, Hanzhao Yang, Zhenzhen Liu
Summary: This study identified 108 glycolysis-related differentially expressed genes (DEGs) between breast cancer tumor tissues and normal tissues, and divided patients into two distinct clusters with different characteristics. A 10-gene signature was constructed to classify TNBC into low- and high-risk groups, and the high-risk group had significantly lower survival. A prognostic nomogram was constructed and validated to accurately predict individual overall survival of TNBC, and the risk score also predicted drug sensitivity of chemotherapeutic agents and immunotherapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kezhen Yi, Jianyuan Wu, Xuan Tang, Qian Zhang, Bicheng Wang, Fubing Wang
Summary: In this study, a glycolysis-related five-gene signature associated with the prognosis of COAD patients was identified, and a risk staging model was developed. Results suggest that prognostic markers based on glycolysis-related genes may be a reliable predictive tool for the prognosis of COAD patients. The predictive value of the glycolysis-related gene signature was shown to be independent of clinical variables, potentially valuable for clinical management.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Qianwei Xing, Tengyue Zeng, Shouyong Liu, Hong Cheng, Limin Ma, Yi Wang
Summary: A novel signature based on 10 prognostic GRGs was successfully established and externally and internally validated for predicting OS of ccRCC, assisting clinicians in better predicting patients' survival.
Article
Obstetrics & Gynecology
Qian Ying, Xueqin You, Jingye You, Jimei Wang
Summary: In this retrospective study, the correlation and consistency between transcutaneous bilirubin (TcB) measured by a JM-103 bilirubinometer and total serum bilirubin (TSB) were analyzed. Overall, there was a strong correlation between TcB and TSB, but differences were observed in certain subgroups such as preterm infants, outpatients, and infants with high TSB levels. Factors like small for gestational age, postnatal age of hour, ABO hemolytic disease, and outpatient setting were found to contribute to inconsistencies between TcB and TSB.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Biochemical Research Methods
Feng Jiang, Chuyan Wu, Ming Wang, Ke Wei, Jimei Wang
Summary: A signature of 9 lncRNAs related to autophagy has been identified as a prognostic marker for breast cancer. The high-risk group showed shorter survival time compared to the low-risk group. This lncRNA signature demonstrated high sensitivity and precision. Gene set enrichment analysis revealed significant enrichment of cancer pathways.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2022)
Article
Cell Biology
Feng Jiang, Yifang Hu, Xiaoqin Liu, Ming Wang, Chuyan Wu
Summary: This study reveals the significance and impact of m(6)A modification patterns in the tumor microenvironment. By assessing the m(6)A modification patterns, it is possible to predict the inflammatory stage, subtype, TME interstitial activity, and prognosis of tumors, leading to the development of more effective immunotherapy strategies.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Oncology
Chen-Rui Guo, Yan Mao, Feng Jiang, Chen-Xia Juan, Guo-Ping Zhou, Ning Li
Summary: Evidence has shown the importance of lncRNAs in genome instability, with 185 candidate lncRNAs associated with genomic instability in lung adenocarcinoma identified in this study. A six lncRNA-based signature was established for assigning patients to high- and low-risk groups with different prognoses, which was validated in separate cohorts of LUAD patients and found to be closely linked to genomic mutation rates.
Article
Gastroenterology & Hepatology
Yuanyuan Feng, Xinfang Tang, Changcheng Li, Ying Su, Xiaoyu Wang, Ning Li, Anna Zhang, Feng Jiang, Chuyan Wu
Summary: This study reveals the association between ARID1A expression and prognosis in hepatocellular carcinoma, with higher expression levels indicating worse prognosis. ARID1A expression is inversely related to tumor immune cell infiltration.
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Endocrinology & Metabolism
Yifang Hu, Ni Zeng, Yaoqi Ge, Dan Wang, Xiaoxuan Qin, Wensong Zhang, Feng Jiang, Yun Liu
Summary: This study firstly revealed the shared gene signatures and molecular processes between PC and T2DM, and identified S100A6 as a potential biomarker and therapeutic target for patients with these conditions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Jie Wu, Lichun Lu, Chen Wang, Feng Jiang
Summary: This study found that pyroptosis-based lncRNAs were useful in predicting the survival of LGG patients, suggesting that they may be used as a therapeutic target in the future.
JOURNAL OF ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yan Mao, Feng Jiang, Xue-Jiao Xu, Lan-Bo Zhou, Rui Jin, Li -Li Zhuang, Chen-Xia Juan, Guo-Ping Zhou
Summary: This study found that IGF2BP1 induces pyroptosis in renal tubular cells, which is associated with the development of septic acute kidney injury (AKI). The upregulation of MIF through IGF2BP1-mediated regulation of E2F1 was crucial for pyroptosis induction. Inhibiting IGF2BP1 could be a potential therapy for septic AKI.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Erli Mao, Zhaohui Qu, Juan Jin, Cui Yao, Wenjun Lyu, Feng Jiang, Hui Ding, Chuyan Wu
Summary: This study examines the rehabilitation nursing of patients with both COVID-19 and cerebral infarction. It is found that developing a nursing plan for COVID-19 patients and implementing early rehabilitation nursing for cerebral infarction patients are crucial. Timely rehabilitation nursing intervention significantly improves treatment outcomes and enhances patient rehabilitation in terms of complications, motor function, and daily activities.
Article
Dermatology
Yuan Li, Wei Zhang, Gaihe Chen, Peng Zhao, Chuyan Wu, Yunlei Bao, Feng Jiang, Ni Zeng, Yan Ding
Summary: This study used Mendelian randomization to investigate the relationship between childhood BMI and psoriasis. The analysis of the data found a causal relationship between childhood BMI and psoriasis, suggesting that an increased childhood BMI is associated with a higher risk of psoriasis.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Urology & Nephrology
Fang Wang, Xiaoli Wang, Yuanxiang Shi, Ling Li, Yu Zheng, Huaying Liu, Min Zeng, Feng Jiang, Zhimin Wu
Summary: The study developed a risk model to predict urinary tract infection risk for cervical cancer patients who underwent indwelling catheterization after radical surgery, incorporating factors such as age, history of chemotherapy before surgery, indwelling catheterization duration, whether it is secondary indwelling catheterization, and history of UTI.
PROGRES EN UROLOGIE
(2023)
Article
Multidisciplinary Sciences
Zhengyun Hu, Chong Liu, Yan Mao, Jianwei Shi, Jinwen Xu, Guoping Zhou, Feng Jiang
Summary: This study investigated the role of ferroptosis-related genes in bronchopulmonary dysplasia (BPD) using a database analysis. It identified 20 differentially expressed genes associated with BPD and developed a predictive nomogram. The study also found significant differences in immune cell infiltration between BPD and control samples.