Cytoplasmic HMGB1 induces renal tubular ferroptosis after ischemia/reperfusion

PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis

(2022) Hai-Liang Zhang et al.   NATURE CELL BIOLOGY

The mechanism of HMGB1 secretion and release

(2022) Ruochan Chen et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Blocking connexin 43 and its promotion of ATP release from renal tubular epithelial cells ameliorates renal fibrosis

(2022) Huzi Xu et al.   Cell Death & Disease

ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation

(2021) Yu Cui et al.   BRAIN BEHAVIOR AND IMMUNITY

HMGB1 regulates ferroptosis through Nrf2 pathway in mesangial cells in response to high glucose

(2021) You Wu et al.   BIOSCIENCE REPORTS

Acute kidney injury

(2021) John A. Kellum et al.   Nature Reviews Disease Primers

XJB-5-131 inhibited ferroptosis in tubular epithelial cells after ischemia−reperfusion injury

(2020) Zhi Zhao et al.   Cell Death & Disease

Identification of Milk Fat Metabolism-Related Pathways of the Bovine Mammary Gland during Mid and Late Lactation and Functional Verification of the ACSL4 Gene

(2020) Yongliang Fan et al.   Genes

Regulated necrosis in kidney ischemia-reperfusion injury

(2019) Aspasia Pefanis et al.   KIDNEY INTERNATIONAL

Acute kidney injury

(2019) Claudio Ronco et al.   LANCET

Renal tubule injury: a driving force toward chronic kidney disease

(2018) Bi-Cheng Liu et al.   KIDNEY INTERNATIONAL

Pretreatment of Huaiqihuang extractum protects against cisplatin-induced nephrotoxicity

(2018) Yujiao Guo et al.   Scientific Reports

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury

(2018) Ruochen Qi et al.   Cell Death & Disease

Plantago asiatica L. Ameliorates Puromycin Aminonucleoside-Induced Nephrotic Syndrome by Suppressing Inflammation and Apoptosis

(2017) Min Kho et al.   Nutrients

Acute Kidney Injury

(2016) Anna Zuk et al.   Annual Review of Medicine

Improved renal ischemia tolerance in females influences kidney transplantation outcomes

(2016) David D. Aufhauser et al.   JOURNAL OF CLINICAL INVESTIGATION

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI

(2016) Diego Martin-Sanchez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

High Mobility Group Box 1 Promotes Angiogenesis from Bone Marrow-derived Endothelial Progenitor Cells after Myocardial Infarction

(2015) Yuichi Nakamura et al.   Journal of Atherosclerosis and Thrombosis

Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation

(2015) Xiaorong Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Necroinflammation in Kidney Disease

(2015) S. R. Mulay et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

High-mobility group box 1 is a novel deacetylation target of Sirtuin1

(2015) May M. Rabadi et al.   KIDNEY INTERNATIONAL

High-Mobility Group Box 1 Is Dispensable for Autophagy, Mitochondrial Quality Control, and Organ Function In Vivo

(2014) Peter Huebener et al.   Cell Metabolism

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

(2014) Peter Huebener et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulated Cell Death in AKI

(2014) A. Linkermann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The NLRP3/ASC inflammasome promotes T-cell-dependent immune complex glomerulonephritis by canonical and noncanonical mechanisms

(2014) Kirstin Andersen et al.   KIDNEY INTERNATIONAL

Carbon monoxide potently prevents ischemia-induced high-mobility group box 1 translocation and release and protects against lethal renal ischemia–reperfusion injury

(2014) Yongle Ruan et al.   KIDNEY INTERNATIONAL

HMGB1 in health and disease

(2014) Rui Kang et al.   MOLECULAR ASPECTS OF MEDICINE

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective Effect of Neutralization of the Extracellular High-Mobility Group Box 1 on Renal Ischemia-Reperfusion Injury in Miniature Swine

(2014) Kohei Miura et al.   TRANSPLANTATION

Cardiac nuclear high mobility group box 1 prevents the development of cardiac hypertrophy and heart failure

(2013) Akira Funayama et al.   CARDIOVASCULAR RESEARCH

Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: A role for intracellular high-mobility group box 1 in cellular protection

(2013) Hai Huang et al.   HEPATOLOGY

Preconditioning with recombinant high-mobility group box 1 protein protects the kidney against ischemia–reperfusion injury in mice

(2013) Huiling Wu et al.   KIDNEY INTERNATIONAL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis

(2012) Agneta Zickert et al.   ARTHRITIS RESEARCH & THERAPY

Hemoperfusion Treatment in a Septic Shock Patient with Autosomal Dominant Polycystic Kidney Disease and Increased HMGB1 Protein Levels

(2011) Tsukasa Nakamura et al.   BLOOD PURIFICATION

High-Mobility Group Box 1 Is Essential for Mitochondrial Quality Control

(2011) Daolin Tang et al.   Cell Metabolism

HMGB1 Contributes to Kidney Ischemia Reperfusion Injury

(2010) H. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Neutralization of the extracellular HMGB1 released by ischaemic-damaged renal cells protects against renal ischaemia-reperfusion injury

(2010) J. Li et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

High-mobility group box 1 restores cardiac function after myocardial infarction in transgenic mice

(2008) T. Kitahara et al.   CARDIOVASCULAR RESEARCH

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(2008) Annette Bruchfeld et al.   MOLECULAR MEDICINE