Optogenetic Control of Muscles: Potential Uses and Limitations

Red Light Optogenetics in Neuroscience

(2022) Kimmo Lehtinen et al.   Frontiers in Cellular Neuroscience

Selective optogenetic control of Gq signaling using human Neuropsin

(2022) Ahmed Wagdi et al.   Nature Communications

Optogenetic activation of the diaphragm

(2022) Ethan S. Benevides et al.   Scientific Reports

Contractile Force of Transplanted Cardiomyocytes Actively Supports Heart Function After Injury

(2022) Tim Stüdemann et al.   CIRCULATION

Wireless, fully implantable cardiac stimulation and recording with on-device computation for closed-loop pacing and defibrillation

(2022) Jokubas Ausra et al.   Science Advances

WiChR, a highly potassium-selective channelrhodopsin for low-light one- and two-photon inhibition of excitable cells

(2022) Johannes Vierock et al.   Science Advances

Optogenetic activation of the tongue in spontaneously breathing mice

(2022) Michele L. Singer et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Dose-Escalation Study of Systemically Delivered rAAVrh74.MHCK7.micro-dystrophin in the mdx Mouse Model of Duchenne Muscular Dystrophy

(2021) Rachael A Potter et al.   HUMAN GENE THERAPY

Optogenetic therapy: high spatiotemporal resolution and pattern discrimination compatible with vision restoration in non-human primates

(2021) Gregory Gauvain et al.   Communications Biology

Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species

(2021) Mohammadsharif Tabebordbar et al.   CELL

Partial recovery of visual function in a blind patient after optogenetic therapy

(2021) José-Alain Sahel et al.   NATURE MEDICINE

Circumventing the packaging limit of AAV-mediated gene replacement therapy for neurological disorders

(2021) Lara Marrone et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Fourth Boy Dies in Clinical Trial of Astellas' AT132

(2021) Alex Philippidis   HUMAN GENE THERAPY

High-Throughput In Vitro, Ex Vivo, and In Vivo Screen of Adeno-Associated Virus Vectors Based on Physical and Functional Transduction

(2020) Adrian Westhaus et al.   HUMAN GENE THERAPY

Muscle-Directed Delivery of an AAV1 Vector Leads to Capsid-Specific T Cell Exhaustion in Nonhuman Primates and Humans

(2020) Gwladys Gernoux et al.   MOLECULAR THERAPY

An Ultra-Sensitive Step-Function Opsin for Minimally Invasive Optogenetic Stimulation in Mice and Macaques

(2020) Xin Gong et al.   NEURON

Optogenetic activation of muscle contraction in vivo

(2020) Elahe Ganji et al.   CONNECTIVE TISSUE RESEARCH

Assessment of Systemic Delivery of rAAVrh74.MHCK7.micro-dystrophin in Children With Duchenne Muscular Dystrophy

(2020) Jerry R. Mendell et al.   JAMA Neurology

Timing of Intensive Immunosuppression Impacts Risk of Transgene Antibodies after AAV Gene Therapy in Nonhuman Primates

(2020) Benjamin J. Samelson-Jones et al.   Molecular Therapy-Methods & Clinical Development

An automated hybrid bioelectronic system for autogenous restoration of sinus rhythm in atrial fibrillation

(2019) Emile C. A. Nyns et al.   Science Translational Medicine

Optogenetic Termination of Cardiac Arrhythmia: Mechanistic Enlightenment and Therapeutic Application?

(2019) Philipp Sasse et al.   Frontiers in Physiology

A muscle hybrid promoter as a novel tool for gene therapy

(2019) Katarzyna Piekarowicz et al.   Molecular Therapy-Methods & Clinical Development

Sono-optogenetics facilitated by a circulation-delivered rechargeable light source for minimally invasive optogenetics

(2019) Xiang Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining the ionic mechanisms of optogenetic control of vascular tone by channelrhodopsin-2

(2018) Nils J G Rorsman et al.   BRITISH JOURNAL OF PHARMACOLOGY

Spectrally distinct channelrhodopsins for two-colour optogenetic peripheral nerve stimulation

(2018) Benjamin E. Maimon et al.   Nature Biomedical Engineering

Optogenetic Peripheral Nerve Immunogenicity

(2018) Benjamin E. Maimon et al.   Scientific Reports

Exposure to wild-type AAV drives distinct capsid immunity profiles in humans

(2018) Klaudia Kuranda et al.   JOURNAL OF CLINICAL INVESTIGATION

A wireless closed-loop system for optogenetic peripheral neuromodulation

(2018) Aaron D. Mickle et al.   NATURE

Potassium channel-based optogenetic silencing

(2018) Yinth Andrea Bernal Sierra et al.   Nature Communications

Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration

(2018) Amine Meliani et al.   Nature Communications

Closed-loop functional optogenetic stimulation

(2018) Shriya S. Srinivasan et al.   Nature Communications

Cardiac Electrophysiological Effects of Light-Activated Chloride Channels

(2018) Ramona A. Kopton et al.   Frontiers in Physiology

Energy-Reduced Arrhythmia Termination Using Global Photostimulation in Optogenetic Murine Hearts

(2018) Raúl A. Quiñonez Uribe et al.   Frontiers in Physiology

Induction of T-Cell Infiltration and Programmed Death Ligand 2 Expression by Adeno-Associated Virus in Rhesus Macaque Skeletal Muscle and Modulation by Prednisone

(2017) Megan L. Cramer et al.   HUMAN GENE THERAPY

Transdermal optogenetic peripheral nerve stimulation

(2017) Benjamin E Maimon et al.   Journal of Neural Engineering

Optogenetic Modulation of Urinary Bladder Contraction for Lower Urinary Tract Dysfunction

(2017) Jae Hong Park et al.   Scientific Reports

Optogenetic termination of ventricular arrhythmias in the whole heart: towards biological cardiac rhythm management

(2016) Emile C.A. Nyns et al.   EUROPEAN HEART JOURNAL

Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations

(2016) Tobias Bruegmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Anion channelrhodopsins for inhibitory cardiac optogenetics

(2016) Elena G. Govorunova et al.   Scientific Reports

Optogenetics design of mechanistically-based stimulation patterns for cardiac defibrillation

(2016) Claudia Crocini et al.   Scientific Reports

Systemic gene transfer enables optogenetic pacing of mouse hearts

(2015) C. C. Vogt et al.   CARDIOVASCULAR RESEARCH

Optogenetics for in vivo cardiac pacing and resynchronization therapies

(2015) Udi Nussinovitch et al.   NATURE BIOTECHNOLOGY

Optogenetic approach for functional assays of the cardiovascular system by light activation of the vascular smooth muscle

(2015) Yang Wu et al.   VASCULAR PHARMACOLOGY

Direct optical activation of skeletal muscle fibres efficiently controls muscle contraction and attenuates denervation atrophy

(2015) Philippe Magown et al.   Nature Communications

Optogenetic control of contractile function in skeletal muscle

(2015) Tobias Bruegmann et al.   Nature Communications

Evaluation of Readministration of a Recombinant Adeno-Associated Virus Vector Expressing Acid Alpha-Glucosidase in Pompe Disease: Preclinical to Clinical Planning

(2015) Manuela Corti et al.   Human Gene Therapy Clinical Development

Independent optical excitation of distinct neural populations

(2014) Nathan C Klapoetke et al.   NATURE METHODS

Adeno-associated viral vectors do not efficiently target muscle satellite cells

(2014) Andrea LH Arnett et al.   Molecular Therapy-Methods & Clinical Development

Human Treg responses allow sustained recombinant adeno-associated virus–mediated transgene expression

(2013) Christian Mueller et al.   JOURNAL OF CLINICAL INVESTIGATION

ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation

(2013) John Y Lin et al.   NATURE NEUROSCIENCE

Phase 2 Clinical Trial of a Recombinant Adeno-Associated Viral Vector Expressing α1-Antitrypsin: Interim Results

(2011) Terence R. Flotte et al.   HUMAN GENE THERAPY

Phase 1 Gene Therapy for Duchenne Muscular Dystrophy Using a Translational Optimized AAV Vector

(2011) Dawn E Bowles et al.   MOLECULAR THERAPY

Ultra light-sensitive and fast neuronal activation with the Ca2+-permeable channelrhodopsin CatCh

(2011) Sonja Kleinlogel et al.   NATURE NEUROSCIENCE

Prevention and Reversal of Antibody Responses Against Factor IX in Gene Therapy for Hemophilia B

(2011) Sushrusha Nayak et al.   Frontiers in Microbiology

Sustained alpha-sarcoglycan gene expression after gene transfer in limb-girdle muscular dystrophy, type 2D

(2010) Jerry R. Mendell et al.   ANNALS OF NEUROLOGY

A user's guide to channelrhodopsin variants: features, limitations and future developments

(2010) John Y. Lin   EXPERIMENTAL PHYSIOLOGY

Orderly recruitment of motor units under optical control in vivo

(2010) Michael E Llewellyn et al.   NATURE MEDICINE

Optogenetic control of heart muscle in vitro and in vivo

(2010) Tobias Bruegmann et al.   NATURE METHODS

Ultrafast optogenetic control

(2010) Lisa A Gunaydin et al.   NATURE NEUROSCIENCE

Limb-girdle muscular dystrophy type 2D gene therapy restores α-sarcoglycan and associated proteins

(2009) Jerry R. Mendell et al.   ANNALS OF NEUROLOGY

Structural Guidance of the Photocycle of Channelrhodopsin-2 by an Interhelical Hydrogen Bond

(2009) Christian Bamann et al.   BIOCHEMISTRY

Construction and analysis of compact muscle-specific promoters for AAV vectors

(2008) B Wang et al.   GENE THERAPY

Light-Induced Rescue of Breathing after Spinal Cord Injury

(2008) W. J. Alilain et al.   JOURNAL OF NEUROSCIENCE

Correction of Multiple Striated Muscles in Murine Pompe Disease Through Adeno-associated Virus–mediated Gene Therapy

(2008) Baodong Sun et al.   MOLECULAR THERAPY