Spontaneous and multifaceted ATP release from astrocytes at the scale of hundreds of synapses

Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions

(2022) Eszter Császár et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ultrastructural view of astrocyte arborization, astrocyte-astrocyte and astrocyte-synapse contacts, intracellular vesicle-like structures, and mitochondrial network

(2022) Sydney Aten et al.   PROGRESS IN NEUROBIOLOGY

Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions

(2022) Shaopeng Chi et al.   NEURON

Real-time denoising enables high-sensitivity fluorescence time-lapse imaging beyond the shot-noise limit

(2022) Xinyang Li et al.   NATURE BIOTECHNOLOGY

Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement

(2021) Youichi Iwai et al.   Frontiers in Neural Circuits

Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice

(2021) Qian Wang et al.   Nature Communications

A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo

(2021) Zhaofa Wu et al.   NEURON

SciPy 1.0: fundamental algorithms for scientific computing in Python

(2020) Pauli Virtanen et al.   NATURE METHODS

New frontiers in probing the dynamics of purinergic transmitters in vivo

(2020) Zhaofa Wu et al.   NEUROSCIENCE RESEARCH

Structural basis of astrocytic Ca2+ signals at tripartite synapses

(2020) Misa Arizono et al.   Nature Communications

Direct Readout of Neural Stem Cell Transgenesis with an Integration-Coupled Gene Expression Switch

(2020) Takuma Kumamoto et al.   NEURON

Two-Photon Voltage Imaging of Spontaneous Activity from Multiple Neurons Reveals Network Activity in Brain Tissue

(2020) Binglun Li et al.   iScience

Array programming with NumPy

(2020) Charles R. Harris et al.   NATURE

Infrared Excitation Induces Heating and Calcium Microdomain Hyperactivity in Cortical Astrocytes

(2020) Elke Schmidt et al.   BIOPHYSICAL JOURNAL

Melanopsin for precise optogenetic activation of astrocyte-neuron networks

(2019) Sara Mederos et al.   GLIA

A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP

(2019) Mark A. Lobas et al.   Nature Communications

Accurate quantification of astrocyte and neurotransmitter fluorescence dynamics for single-cell and population-level physiology

(2019) Yizhi Wang et al.   NATURE NEUROSCIENCE

Volume Electron Microscopy Study of the Relationship Between Synapses and Astrocytes in the Developing Rat Somatosensory Cortex

(2019) Toko Kikuchi et al.   CEREBRAL CORTEX

Astroglia-Derived ATP Modulates CNS Neuronal Circuits

(2019) Peter Illes et al.   TRENDS IN NEUROSCIENCES

ATP Release Channels

(2018) Akiyuki Taruno   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gliotransmission: Beyond Black-and-White

(2018) Iaroslav Savtchouk et al.   JOURNAL OF NEUROSCIENCE

Multiple Lines of Evidence Indicate That Gliotransmission Does Not Occur under Physiological Conditions

(2018) Todd A. Fiacco et al.   JOURNAL OF NEUROSCIENCE

Functional Roles of Astrocyte Calcium Elevations: From Synapses to Behavior

(2018) Sónia Guerra-Gomes et al.   Frontiers in Cellular Neuroscience

Neuronal activity determines distinct gliotransmitter release from a single astrocyte

(2018) Ana Covelo et al.   eLife

TI Workbench, an integrated software package for electrophysiology and imaging

(2018) Takafumi Inoue   Microscopy

Intracortical astrocyte subpopulations defined by astrocyte reporter Mice in the adult brain

(2018) Lydie Morel et al.   GLIA

Morphological profile determines the frequency of spontaneous calcium events in astrocytic processes

(2018) Yu-Wei Wu et al.   GLIA

Spatiotemporal pattern of calcium activity in astrocytic network

(2018) Alexey Semyanov   CELL CALCIUM

Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors

(2017) M Jun et al.   MOLECULAR PSYCHIATRY

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

(2017) Amit Agarwal et al.   NEURON

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

(2017) Hua Chai et al.   NEURON

Imaging extracellular ATP with a genetically-encoded, ratiometric fluorescent sensor

(2017) Jason M. Conley et al.   PLoS One

Three-dimensional Ca2+imaging advances understanding of astrocyte biology

(2017) Erika Bindocci et al.   SCIENCE

Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons

(2017) Zhibing Tan et al.   Nature Communications

Skull optical clearing window for in vivo imaging of the mouse cortex at synaptic resolution

(2017) Yan-Jie Zhao et al.   Light-Science & Applications

An autocrine purinergic signaling controls astrocyte-induced neuronal excitation

(2017) Weida Shen et al.   Scientific Reports

Astrocyte calcium waves propagate proximally by gap junction and distally by extracellular diffusion of ATP released from volume-regulated anion channels

(2017) Yuki Fujii et al.   Scientific Reports

Ca2+transients in astrocyte fine processes occur via Ca2+influx in the adult mouse hippocampus

(2016) Ravi L. Rungta et al.   GLIA

Astrocyte calcium signaling: the third wave

(2016) Narges Bazargani et al.   NATURE NEUROSCIENCE

Probing the Complexities of Astrocyte Calcium Signaling

(2016) Eiji Shigetomi et al.   TRENDS IN CELL BIOLOGY

A simple and efficient seamless DNA cloning method using SLiCE from Escherichia coli laboratory strains and its application to SLiP site-directed mutagenesis

(2015) Ken Motohashi   BMC BIOTECHNOLOGY

Astrocyte VAMP3 vesicles undergo Ca2+-independent cycling and modulate glutamate transporter trafficking

(2015) Dongdong Li et al.   JOURNAL OF PHYSIOLOGY-LONDON

Astrocytes, but Not Neurons, Exhibit Constitutive Activation of P2X7 Receptors in Mouse Acute Cortical Slices under Non-stimulated Resting Conditions

(2014) Yosuke Kamatsuka et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Astroglial Connexin43 Hemichannels Tune Basal Excitatory Synaptic Transmission

(2014) O. Chever et al.   JOURNAL OF NEUROSCIENCE

Conditions and Constraints for Astrocyte Calcium Signaling in the Hippocampal Mossy Fiber Pathway

(2014) Martin D. Haustein et al.   NEURON

Gliotransmitters Travel in Time and Space

(2014) Alfonso Araque et al.   NEURON

What do we know about gliotransmitter release from astrocytes?

(2014) D. A. Sahlender et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer’s disease mouse model

(2014) Andrea Delekate et al.   Nature Communications

A long Stokes shift red fluorescent Ca2+ indicator protein for two-photon and ratiometric imaging

(2014) Jiahui Wu et al.   Nature Communications

Exocytosis of ATP From Astrocytes Modulates Phasic and Tonic Inhibition in the Neocortex

(2014) Ulyana Lalo et al.   PLOS BIOLOGY

Astrocyte-derived ATP modulates depressive-like behaviors

(2013) Xiong Cao et al.   NATURE MEDICINE

Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles

(2013) Christian Giaume et al.   Frontiers in Pharmacology

Immunoregulation through extracellular nucleotides

(2012) L. Vitiello et al.   BLOOD

Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

(2012) Jimmy Stehberg et al.   FASEB JOURNAL

ATP signaling is deficient in cultured pannexin1-null mouse astrocytes

(2012) Sylvia O. Suadicani et al.   GLIA

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Neuromodulation by Extracellular ATP and P2X Receptors in the CNS

(2012) Baljit S. Khakh et al.   NEURON

Pannexin1 Stabilizes Synaptic Plasticity and Is Needed for Learning

(2012) Nora Prochnow et al.   PLoS One

Calcium Signaling and Gliotransmission in Normal vs. Reactive Astrocytes

(2012) Cendra Agulhon et al.   Frontiers in Pharmacology

Astrocytes Are Endogenous Regulators of Basal Transmission at Central Synapses

(2011) Aude Panatier et al.   CELL

Glutamate released spontaneously from astrocytes sets the threshold for synaptic plasticity

(2011) Christian Bonansco et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior

(2010) Michael M. Halassa et al.   Annual Review of Physiology

Long-term potentiation depends on release of d-serine from astrocytes

(2010) Christian Henneberger et al.   NATURE

Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss

(2009) Michael M. Halassa et al.   NEURON

Cortical Layer 1 and Layer 2/3 Astrocytes Exhibit Distinct Calcium Dynamics In Vivo

(2008) Norio Takata et al.   PLoS One