Kobayashi Award 2021: Neuropeptides, receptors, and follicle development in the ascidian, Ciona intestinalis Type A: New clues to the evolution of chordate neuropeptidergic systems from biological niches

Omics Studies for the Identification of Ascidian Peptides, Cognate Receptors, and Their Relevant Roles in Ovarian Follicular Development

(2022) Tsuyoshi Kawada et al.   Frontiers in Endocrinology

Mass spectrometry of short peptides reveals common features of metazoan peptidergic neurons

(2022) Eisuke Hayakawa et al.   Nature Ecology & Evolution

Ancestral glycoprotein hormone and its cognate receptor present in primitive chordate ascidian: Molecular identification and functional characterization

(2022) Li-Kun Yang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Identifying Receptors for Neuropeptides and Peptide Hormones: Challenges and Recent Progress

(2021) Md Shadman Ridwan Abid et al.   ACS Chemical Biology

Vasopressin Promoter Transgenic and Vasopressin Gene-Edited Ascidian, Ciona intestinalis Type A (Ciona robusta): Innervation, Gene Expression Profiles, and Phenotypes

(2021) Tsuyoshi Kawada et al.   Frontiers in Endocrinology

Cionin, a vertebrate cholecystokinin/gastrin homolog, induces ovulation in the ascidian Ciona intestinalis type A

(2021) Tomohiro Osugi et al.   Scientific Reports

Comparative analysis of transcriptomic profiles among ascidians, zebrafish, and mice: Insights from tissue-specific gene expression

(2021) Shin Matsubara et al.   PLoS One

Improved protein structure prediction using potentials from deep learning

(2020) Andrew W. Senior et al.   NATURE

The ventral peptidergic system of the adult ascidian Ciona robusta (Ciona intestinalis Type A) insights from a transgenic animal model

(2020) Tomohiro Osugi et al.   Scientific Reports

Expression Profiling, Downstream Signaling, and Inter-subunit Interactions of GPA2/GPB5 in the Adult Mosquito Aedes aegypti

(2020) David A. Rocco et al.   Frontiers in Endocrinology

Machine learning and AI-based approaches for bioactive ligand discovery and GPCR-ligand recognition

(2020) Sebastian Raschka et al.   METHODS

Peptide receptors and immune-related proteins expressed in the digestive system of a urochordate, Ciona intestinalis

(2019) Honoo Satake et al.   CELL AND TISSUE RESEARCH

Repertoires of G protein-coupled receptors for Ciona-specific neuropeptides

(2019) Akira Shiraishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive single-cell transcriptome lineages of a proto-vertebrate

(2019) Chen Cao et al.   NATURE

The regulation of oocyte maturation and ovulation in the closest sister group of vertebrates

(2019) Shin Matsubara et al.   eLife

A Nearly Complete Genome of Ciona intestinalis Type A (C. robusta) Reveals the Contribution of Inversion to Chromosomal Evolution in the Genus Ciona

(2019) Yutaka Satou et al.   Genome Biology and Evolution

The G protein-coupled receptors deorphanization landscape

(2018) Céline Laschet et al.   BIOCHEMICAL PHARMACOLOGY

Agonists of G-Protein-Coupled Odorant Receptors Are Predicted from Chemical Features

(2018) C. Bushdid et al.   Journal of Physical Chemistry Letters

Regulatory cocktail for dopaminergic neurons in a protovertebrate identified by whole-embryo single-cell transcriptomics

(2018) Takeo Horie et al.   GENES & DEVELOPMENT

Shared evolutionary origin of vertebrate neural crest and cranial placodes

(2018) Ryoko Horie et al.   NATURE

Expression and actions of corticotropin-releasing factor/diuretic hormone-like peptide (CDLP) and teneurin C-terminal associated peptide (TCAP) in the vase tunicate, Ciona intestinalis : Antagonism of the feeding response

(2017) Andrea L. D’Aquila et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

The nervous system of the adult ascidian Ciona intestinalis Type A (Ciona robusta): Insights from transgenic animal models

(2017) Tomohiro Osugi et al.   PLoS One

Transcriptomes of the Premature and Mature Ovaries of an Ascidian, Ciona intestinalis

(2017) Tsuyoshi Kawada et al.   Frontiers in Endocrinology

Invertebrate Gonadotropin-Releasing Hormone-Related Peptides and Their Receptors: An Update

(2017) Tsubasa Sakai et al.   Frontiers in Endocrinology

The significance of Ciona intestinalis as a stem organism in integrative studies of functional evolution of the chordate endocrine, neuroendocrine, and nervous systems

(2016) Shin Matsubara et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

(2015) Xi-Ping Huang et al.   NATURE

Large-Scale Combinatorial Deorphanization of Platynereis Neuropeptide GPCRs

(2015) Philipp Bauknecht et al.   Cell Reports

Chemical Genomics Approach for GPCR–Ligand Interaction Prediction and Extraction of Ligand Binding Determinants

(2013) Akira Shiraishi et al.   Journal of Chemical Information and Modeling

Global view of the evolution and diversity of metazoan neuropeptide signaling

(2013) G. Jekely   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular evolution of peptidergic signaling systems in bilaterians

(2013) O. Mirabeau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPCR Heterodimerization in the Reproductive System: Functional Regulation and Implication for Biodiversity

(2013) Honoo Satake et al.   Frontiers in Endocrinology

Evidence for Differential Regulation of GnRH Signaling via Heterodimerization among GnRH Receptor Paralogs in the Protochordate,Ciona intestinalis

(2012) Tsubasa Sakai et al.   ENDOCRINOLOGY

Molecular and functional characterization of cionin receptors in the ascidian, Ciona intestinalis: the evolutionary origin of the vertebrate cholecystokinin/gastrin family

(2012) Toshio Sekiguchi et al.   JOURNAL OF ENDOCRINOLOGY

Cis-Acting Transcriptional Repression Establishes a Sharp Boundary in Chordate Embryos

(2012) K. S. Imai et al.   SCIENCE

Evolutionary crossroads in developmental biology: the tunicates

(2011) P. Lemaire   DEVELOPMENT

Peptidomic Analysis of the Central Nervous System of the Protochordate,Ciona intestinalis: Homologs and Prototypes of Vertebrate Peptides and Novel Peptides

(2011) Tsuyoshi Kawada et al.   ENDOCRINOLOGY

Analysis of multiple compound-protein interactions reveals novel bioactive molecules

(2011) H. Yabuuchi et al.   Molecular Systems Biology

Localization and enzymatic activity profiles of the proteases responsible for tachykinin-directed oocyte growth in the protochordate, Ciona intestinalis

(2011) Masato Aoyama et al.   PEPTIDES

Plasticity of Animal Genome Architecture Unmasked by Rapid Evolution of a Pelagic Tunicate

(2010) F. Denoeud et al.   SCIENCE

Distinct Expression Patterns of Glycoprotein Hormone-α2 and -β5 in a Basal Chordate Suggest Independent Developmental Functions

(2009) Sandra Dos Santos et al.   ENDOCRINOLOGY

Calcitonin in a protochordate,Ciona intestinalis - the prototype of the vertebrate calcitonin/calcitonin gene-related peptide superfamily

(2009) Toshio Sekiguchi et al.   FEBS Journal

Characterization of a corticotropin-releasing factor (CRF)/diuretic hormone-like peptide from tunicates: Insight into the origins of the vertebrate CRF family

(2009) David A. Lovejoy et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

FLR-2, the glycoprotein hormone alpha subunit, is involved in the neural control of intestinal functions inCaenorhabditis elegans

(2009) Akane Oishi et al.   GENES TO CELLS

Development and Validation of a Novel Protein−Ligand Fingerprint To Mine Chemogenomic Space: Application to G Protein-Coupled Receptors and Their Ligands

(2009) Nathanael Weill et al.   Journal of Chemical Information and Modeling

Functional Diversity of Signaling Pathways through G Protein–Coupled Receptor Heterodimerization with a Species-Specific Orphan Receptor Subtype

(2009) Tsubasa Sakai et al.   MOLECULAR BIOLOGY AND EVOLUTION

A novel inhibitory gonadotropin-releasing hormone-related neuropeptide in the ascidian, Ciona intestinalis

(2009) Tsuyoshi Kawada et al.   PEPTIDES

A Novel Biological Role of Tachykinins as an Up-Regulator of Oocyte Growth: Identification of an Evolutionary Origin of Tachykininergic Functions in the Ovary of the Ascidian,Ciona intestinalis

(2008) Masato Aoyama et al.   ENDOCRINOLOGY

Characterization of a novel vasopressin/oxytocin superfamily peptide and its receptor from an ascidian, Ciona intestinalis

(2008) Tsuyoshi Kawada et al.   PEPTIDES