Probing the effects of MR120 in preclinical chronic colitis: A first-in-class anti-IBD agent targeting the CCL20/CCR6 axis

Discovery of small-molecules targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases

(2022) Maria Grazia Martina et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

CCR6-CCL20 axis as a therapeutic target for autoimmune diseases

(2021) Heikrujam Thoihen Meitei et al.   AUTOIMMUNITY REVIEWS

UniPR1331: Small Eph/Ephrin Antagonist Beneficial in Intestinal Inflammation by Interfering with Type-B Signaling

(2021) Carmine Giorgio et al.   Pharmaceuticals

Chemokines and Chemokine Receptors as Therapeutic Targets in Inflammatory Bowel Disease; Pitfalls and Promise

(2018) Palak J Trivedi et al.   Journal of Crohns & Colitis

C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release

(2018) Helene Skovdahl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

α7 Nicotinic Agonist AR-R17779 Protects Mice against 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis in a Spleen-Dependent Way

(2017) Andrea Grandi et al.   Frontiers in Pharmacology

Role of chemokine receptors and intestinal epithelial cells in the mucosal inflammation and tolerance

(2016) Neeraja Kulkarni et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A microwave-assisted multicomponent protocol for the synthesis of benzofuran-2-carboxamides

(2016) Paolo Vincetti et al.   TETRAHEDRON LETTERS

Experimental colitis models: Insights into the pathogenesis of inflammatory bowel disease and translational issues

(2015) Vassilis Valatas et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Expression of CCL20 and Its Corresponding Receptor CCR6 Is Enhanced in Active Inflammatory Bowel Disease, and TLR3 Mediates CCL20 Expression in Colonic Epithelial Cells

(2015) Helene Kolstad Skovdahl et al.   PLoS One

Protective role of tumor necrosis factor (TNF) receptors in chronic intestinal inflammation: TNFR1 ablation boosts systemic inflammatory response

(2013) Yi Wang et al.   LABORATORY INVESTIGATION

CC Chemokine Ligand 20 and Its Cognate Receptor CCR6 in Mucosal T Cell Immunology and Inflammatory Bowel Disease: Odd Couple or Axis of Evil?

(2013) Adrian Y. S. Lee et al.   Frontiers in Immunology

Evaluation of chemical mediators and cellular response during acute and chronic gut inflammatory response induced by dextran sodium sulfate in mice

(2012) Allisson Freire Bento et al.   BIOCHEMICAL PHARMACOLOGY

Distinct Cytokine Patterns Identified from Multiplex Profiles of Murine DSS and TNBS-Induced Colitis

(2008) Philip Alex et al.   INFLAMMATORY BOWEL DISEASES