Foxn1 overexpression promotes thymic epithelial progenitor cell proliferation and mTEC maintenance, but does not prevent thymic involution

FOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency

(2021) Ioanna A. Rota et al.   Science Advances

Generation and Regeneration of Thymic Epithelial Cells

(2020) Abdullah S. Alawam et al.   Frontiers in Immunology

Thymic rejuvenation via FOXN1-reprogrammed embryonic fibroblast (FREF) to counteract age-related inflammation

(2020) Jiyoung Oh et al.   JCI Insight

Inborn errors of thymic stromal cell development and function

(2020) Alexandra Y. Kreins et al.   Seminars in Immunopathology

Foxn1 in Skin Development, Homeostasis and Wound Healing

(2018) Joanna Bukowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rapid chromatin repression by Aire provides precise control of immune tolerance

(2018) Andrew S. Koh et al.   NATURE IMMUNOLOGY

Thymic B cell development is controlled by the B potential of progenitors via both hematopoietic-intrinsic and thymic microenvironment-intrinsic regulatory mechanisms

(2018) Shiyun Xiao et al.   PLoS One

Fundamental parameters of the developing thymic epithelium in the mouse

(2018) Mayumi Hirakawa et al.   Scientific Reports

Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus

(2017) Muhammad Myn Uddin et al.   Nature Communications

FOXN1 in thymus organogenesis and development

(2016) Harsh Jayesh Vaidya et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells

(2016) Saulius Žuklys et al.   NATURE IMMUNOLOGY

Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus

(2016) Svetlana Ulyanchenko et al.   Cell Reports

Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution

(2016) Kathy E. O’Neill et al.   PLoS One

Thymic Involution Perturbs Negative Selection Leading to Autoreactive T Cells That Induce Chronic Inflammation

(2015) Brandon D. Coder et al.   JOURNAL OF IMMUNOLOGY

Regeneration of the aged thymus by a single transcription factor

(2014) N. Bredenkamp et al.   DEVELOPMENT

An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts

(2014) Nicholas Bredenkamp et al.   NATURE CELL BIOLOGY

Long-Term Persistence of Functional Thymic Epithelial Progenitor Cells In Vivo under Conditions of Low FOXN1 Expression

(2014) Xin Jin et al.   PLoS One

Generation of both cortical and Aire+medullary thymic epithelial compartments from CD205+progenitors

(2013) Song Baik et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cell-Autonomous Defects in Thymic Epithelial Cells Disrupt Endothelial-Perivascular Cell Interactions in the Mouse Thymus

(2013) Jerrod L. Bryson et al.   PLoS One

FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program

(2013) Rosa Romano et al.   Frontiers in Immunology

From Murine to Human Nude/SCID: The Thymus, T-Cell Development and the Missing Link

(2012) Rosa Romano et al.   Clinical & Developmental Immunology

Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells

(2011) E. C. Zook et al.   BLOOD

Mechanisms of thymus organogenesis and morphogenesis

(2011) J. Gordon et al.   DEVELOPMENT

Foxn1 Regulates Lineage Progression in Cortical and Medullary Thymic Epithelial Cells But Is Dispensable for Medullary Sublineage Divergence

(2011) Craig S. Nowell et al.   PLoS Genetics

Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage

(2010) T. Corbeaux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Foxn1 is essential for vascularization of the murine thymus anlage

(2009) Kazuya Mori et al.   CELLULAR IMMUNOLOGY

Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner

(2008) L. Chen et al.   BLOOD

Identification of Plet-1 as a specific marker of early thymic epithelial progenitor cells

(2008) M. G. L. Depreter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA