Article
Immunology
ChunYan Yuan
Summary: IL-33 is a cytokine that modulates inflammation and immune responses, primarily associated with the development of Th2 immunological responses. It has been shown to be elevated in various autoimmune disorders, suggesting a role in inducing autoimmunity and inflammatory damage. The IL-33/ST2 axis holds promising potential as a therapeutic target for autoimmune disease treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medical Laboratory Technology
Seyedeh Mahsa Mahmoudinezhad Dezfouli, Shima Salehi, Shaqayeq Khosravi
Summary: Infancy and early childhood are the most common ages for acute pyretic Kawasaki disease (KD). The etiology remains unknown, but it is believed to be caused by a contagious pathogen that induces an inflammatory response. High-dose intravenous immunoglobulin (IVIG) administration can resolve the inflammation and decrease the incidence of coronary anomalies. The etiology is linked to cytokines, and treatment strategies aim to regulate these cytokines.
CLINICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Anna Lebedeva, Ivan Molodtsov, Alexandra Anisimova, Anastasia Berestovskaya, Oleg Dukhin, Antonina Elizarova, Wendy Fitzgerald, Darya Fomina, Kseniya Glebova, Oxana Ivanova, Anna Kalinskaya, Anastasia Lebedeva, Maryana Lysenko, Elena Maryukhnich, Elena Misyurina, Denis Protsenko, Alexander Rosin, Olga Sapozhnikova, Denis Sokorev, Alexander Shpektor, Daria Vorobyeva, Elena Vasilieva, Leonid Margolis
Summary: COVID-19 patients with cytokine storm syndrome (CSS) and those without formed distinct clusters based on their cytokine concentrations. However, the administration of tocilizumab therapy did not fully correspond to these CSS clusters. IL-1RA was found to be prognostically significant in both groups and may be useful in defining the onset of a cytokine storm and indicating anti-cytokine therapy in COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Kenta Fujimura, Tadayoshi Karasawa, Takanori Komada, Naoya Yamada, Yoshiko Mizushina, Chintogtokh Baatarjav, Takayoshi Matsumura, Kinya Otsu, Norihiko Takeda, Hiroaki Mizukami, Kazuomi Kario, Masafumi Takahashi
Summary: Sepsis is a life-threatening syndrome, and its associated mortality is increased when cardiac dysfunction and damage (septic cardiomyopathy [SCM]) occur. The NLRP3 inflammasome plays a critical role in the pathophysiology of SCM, with the activation of IL-1 beta and IL-18 contributing to the development of SCM.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Review
Immunology
Praxedis Martin, Jeremie D. Goldstein, Loic Mermoud, Alejandro Diaz-Barreiro, Gaby Palmer
Summary: IL-1 family cytokines play important roles in skin disorders, and dysregulated signaling may lead to the development of chronic inflammatory diseases. Anti-inflammatory IL-1 family members such as IL-1Ra and IL-36Ra control the biological activity of pro-inflammatory IL-1 family agonists. These cytokines are highly expressed in the epidermis and have therapeutic potential for human inflammatory skin diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Obstetrics & Gynecology
Zubeen D. Azari, Fatimah Aljubran, Warren B. Nothnick
Summary: Emerging data suggests that endometriosis is associated with subclinical atherosclerosis, and both diseases are linked to inflammation. MicroRNAs play a crucial role in regulating inflammatory pathways and their circulating levels have been found altered in both endometriosis and atherosclerosis. This review discusses the differentially expressed inflammatory circulating miRNAs in endometriosis, compares them to circulating levels associated with atherosclerosis when possible, and explores their mechanistic studies in relevant models.
REPRODUCTIVE SCIENCES
(2022)
Review
Immunology
Vu L. Ngo, Michal Kuczma, Estera Maxim, Timothy L. Denning
Summary: IL-36, a group of cytokines belonging to the IL-1 superfamily, plays a role in the pathogenesis of inflammatory disorders. In the gastrointestinal tract, IL-36 has a complex function with receptor ligands having important roles in inflammatory settings. Ongoing trials aim to block IL-36R signaling for treating chronic intestinal inflammation.
Article
Cell Biology
Yuri Park, Yeon Jean Cho, Nuri Sung, Mi Jin Park, Xiaoming Guan, William E. Gibbons, Bert W. O'Malley, Sang Jun Han
Summary: In this study, researchers identified a natural product called oleuropein that selectively inhibits ER beta activity without affecting ER alpha activity, thus suppressing the progression of endometriosis and improving fertility in patients.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
James Byrne, Kevin Baker, Aileen Houston, Elizabeth Brint
Summary: The IL-36 family of cytokines was first identified in 2000, and its functions in health and disease have only been appreciated in the last decade. Over activation of IL-36 has been associated with many inflammatory diseases including Psoriasis and cancer.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Nandhini Balunathan, G. Usha Rani, Venkatachalam Perumal, P. Kumarasamy
Summary: This study aimed to analyze the polymorphisms in Interleukin 4, Interleukin 18, FCRL3, and sPLA2IIa genes to identify their significant association with the risk of endometriosis. The results showed that the polymorphisms in Interleukin 18 and FCRL3 genes were significantly associated with endometriotic tissue and blood samples of endometriosis, while no significant difference was found in Interleukin 4 and sPLA2IIa gene polymorphisms. These findings provide valuable knowledge of endometriosis's pathogenesis.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Clinical Neurology
Ryul Kim, Han-Joon Kim, Jung Hwan Shin, Chan Young Lee, Seung Ho Jeon, Beomseok Jeon
Summary: This study found that peripheral inflammation in early-stage Parkinson's disease (PD) may be related to the progression of nonmotor symptoms (NMSs), particularly mood symptoms. By measuring six inflammatory markers, the researchers found that elevated levels of IL-2 and IL-6 were associated with the progression of NMSs.
MOVEMENT DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Gerwyn Morris, Chiara C. Bortolasci, Basant K. Puri, Wolfgang Marx, Adrienne O'Neil, Eugene Athan, Ken Walder, Michael Berk, Lisa Olive, Andre F. Carvalho, Michael Maes
Summary: An analysis of cytokine storms in diseases like COVID-19, H1N1 influenza, cytokine release syndrome (CRS), and macrophage activation syndrome (MAS) reveals common immunological and biochemical abnormalities. These include hyperactive coagulation systems, elevated levels of cytokines, proinflammatory chemokines, and activated macrophages. Differences in immune responses and cytokine levels are also observed among these diseases. Additional elements such as Inflammasome activity and DAMPs contribute to the pathophysiology of cytokine storms.
Article
Microbiology
Dewei Li, Abidan Ainiwaer, Xuran Zheng, Maolin Wang, Yang Shi, Zibigu Rousu, Xinling Hou, Xuejiao Kang, Muesier Maimaiti, Hui Wang, Jing Li, Chuanshan Zhang
Summary: Infection with the cestode Echinococcus multilocularis (E. multilocularis) causes alveolar echinococcosis (AE), which is a tumor-like disease that predominantly affects the liver but can spread to any organ. High expression of the inhibitory receptor LAG3 promotes the formation of Th2 cells and Tregs, resulting in immune tolerance and disease progression in chronic E. multilocularis infection. LAG3 deficiency enhances the type 1 CD4(+) T-cell immune response and inhibits metacestode growth in vivo. These findings suggest that LAG3 blockade may be an effective immunotherapeutic strategy against AE.
Review
Dermatology
Amir Mohammad Beyzaee, Mohamad Goldust, Anant Patil, Ghasem Rahmatpour Rokni, Samira Beyzaee
Summary: This narrative review summarizes the evidence related to cytokines and vitiligo development in the past 20 years. The dysregulated levels of cytokines and their synergistic function play a crucial role in the onset and progression of the disease. Increased secretion of pro-inflammatory mediators and reduction of anti-inflammatory mediators are associated with the pathogenesis of autoimmune vitiligo. In addition, decreased vitamin D levels may have a significant role in vitiligo development by affecting immune responses.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ali Ganji, Iman Farahani, Amir Mohammad Saeedifar, Ghasem Mosayebi, Ali Ghazavi, Muhammed Majeed, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: Curcumin exerts anti-inflammatory effects by interfering with LPS-induced inflammatory pathways, potentially reducing the pathophysiological consequences of LPS toxicity.
Further clinical studies are needed to confirm the efficacy of Curcumin in reducing inflammatory responses.
Curcumin has the potential to become a promising drug for the treatment of LPS toxicity in the future.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Obstetrics & Gynecology
Andrei Mihai Malutan, Cristina Drugan, Katharina Walch, Tudor Drugan, Razvan Ciortea, Dan Mihu
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2017)
Article
Obstetrics & Gynecology
Monica G. Hasmasanu, Melinda Baizat, Lucia Maria Procopciuc, Ligia Blaga, Madalina A. Valeanu, Tudor C. Drugan, Gabriela C. Zaharie, Sorana D. Bolboaca
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2018)
Article
Toxicology
Anca Pop, Tudor Drugan, Arno C. Gutleb, Diana Lupu, Julien Cherfan, Felicia Loghin, Bela Kiss
JOURNAL OF APPLIED TOXICOLOGY
(2018)
Article
Clinical Neurology
Ana Banc, Cristina Stan, Alexandra-Stefania Berghe, Tudor Catalin Drugan, Ioan-Stefan Florian
WORLD NEUROSURGERY
(2018)
Article
Infectious Diseases
Narcisse Patrice Komas, Sumantra Ghosh, Mariama Abdou-Chekaraou, Pierre Pradat, Nasser Al Hawajri, Alexandre Manirakiza, Gina Laure Laghoe, Claudine Bekondi, Segolene Brichler, Jean-Omer Ouavene, Abdoulaye Sepou, Brice Martial Yambiyo, Jean Chrysostome Gody, Valentin Fikouma, Athenais Gerber, Natali Abeywickrama Samarakoon, Dulce Alfaiate, Caroline Scholtes, Nora Martel, Frederic Le Gal, Hugo Lo Pinto, Ikram Amri, Olivier Hantz, David Durantel, Jean-Louis Lesbordes, Emmanuel Gordien, Philippe Merle, Tudor Drugan, Christian Trepo, Fabien Zoulim, Jean-Claude Cortay, Alan Campbell Kay, Paul Deny
PLOS NEGLECTED TROPICAL DISEASES
(2018)
Article
Environmental Sciences
Teodora-Irina Adam-Bonci, Paraschiva Chereches-Panta, Eduard-Alexandru Bonci, Sorin Claudiu Man, Ancuta Cutas-Benedec, Tudor Drugan, Raluca Maria Pop, Alexandru Irimie
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Medicine, General & Internal
Ancuta Cutas, Cristina Drugan, Gabriela Roman, Adriana Rusu, Cristina Sorina Catana, Andrei Achimas-Cadariu, Tudor Drugan
Summary: The study found a link between the inflammatory status and the occurrence of microvascular complications in patients with type 1 DM, especially diabetic neuropathy and retinopathy. Chitotriosidase enzymatic activity increased over time, with a faster progression observed in non-smokers. Increased chitotriosidase activity may be a predictor of endothelial dysfunction in type 1 DM.
Article
Environmental Sciences
Mariam Haji-Hassan, Tudor Calinici, Tudor Drugan, Sorana D. Bolboaca
Summary: This study aimed to evaluate students' progress and long-term retention of information in evaluating ultrasound and cadaveric cardiac images. The results showed that the correct identification of cardiovascular structures on ultrasound images significantly improved after training but decreased after six months. In addition, the accurate identification of cardiovascular structures was higher on cadaveric images compared to ultrasound images, and first-year students who received ultrasound training performed better in this regard.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Valentina Sas, Paraschiva Chereches-Panta, Diana Borcau, Cristina-Nicoleta Schnell, Edita-Gabriela Ichim, Daniela Iacob, Alina-Petronela Coblisan, Tudor Drugan, Sorin-Claudiu Man
Summary: Electronic nose (e-nose) is a new technology used to identify volatile organic compounds (VOC) in breath air. It can adequately identify airway inflammation in asthma patients. In this study, the e-nose was able to discriminate pediatric patients with asthma from controls, but the accuracy was lower in the external validation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Lidia Neamti, Tudor Drugan, Cristina Drugan, Ciprian Silaghi, Lidia Ciobanu, Alexandra Craciun
Summary: This study aimed to analyze the most commonly used biomarkers for patient monitoring and follow-up, both independently and as a group, in order to propose an improved activity score that accurately reflects the changes at the intestinal level, to reduce the number of colonoscopic interventions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Larisa Cujba, Cristina Stan, Ovidiu Samoila, Tudor Drugan, Ancuta Benedec (Cutas), Cristina Nicula
Summary: Multiple sclerosis (MS) is a neurological disease that affects the optic nerve and can be diagnosed and monitored using optical coherence tomography (OCT). In a clinical study, patients with MS were compared to healthy controls, and significant thinning of the retinal nerve fiber layer (pRNFL) was observed in MS patients, especially those with optic neuritis. The study also found that retinal changes in MS start from the fovea and spread to the posterior pole.
Article
Medicine, General & Internal
Ioana-Andreea Gheban-Rosca, Bogdan-Alexandru Gheban, Bogdan Pop, Daniela-Cristina Mironescu, Vasile Costel Siserman, Elena Mihaela Jianu, Tudor Drugan, Sorana D. Bolboaca
Summary: This study aimed to evaluate the macro- and microscopic biomarkers of lung damage in patients with fatal COVID-19. The researchers retrospectively analyzed lung tissue samples from autopsies in Romania. The study found that age and infection with the beta variant of the virus were significant factors associated with diffuse alveolar damage.
Proceedings Paper
Computer Science, Interdisciplinary Applications
Roxana-Denisa Capras, Tudor C. Drugan, Sorana D. Bolboaca
2017 IEEE INTERNATIONAL CONFERENCE ON E-HEALTH AND BIOENGINEERING CONFERENCE (EHB)
(2017)
Article
Medical Laboratory Technology
Razvan A. Ciocan, Cristina Drugan, Claudia D. Gherman, Cristina-Sorina Catana, Andra Ciocan, Tudor C. Drugan, Sorana D. Bolboaca
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2017)
Article
Medicine, Research & Experimental
Cristina Drugan, Tudor Drugan, Catherine Caillaud, Paula Grigorescu-Sido, Tiberiu Nistor, Alexandra M. Craciun
REVISTA ROMANA DE MEDICINA DE LABORATOR
(2017)
