Game changer or gimmick: inflammatory markers to guide antibiotic treatment decisions in neonatal early-onset sepsis

A Proposed Framework for the Clinical Management of Neonatal “Culture-Negative” Sepsis

(2022) Joseph B. Cantey et al.   JOURNAL OF PEDIATRICS

Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial

(2022) Marta Reyman et al.   Nature Communications

Reliability of Interleukin-6 Alone and in Combination for Diagnosis of Early Onset Neonatal Sepsis: Systematic Review

(2022) Julia Eichberger et al.   Frontiers in Pediatrics

Should we give antibiotics to neonates with mild non-progressive symptoms? A comparison of serial clinical observation and the neonatal sepsis risk calculator

(2022) Alberto Berardi et al.   Frontiers in Pediatrics

Cut-off values of serum interleukin-6 for culture-confirmed sepsis in neonates

(2022) Erik Küng et al.   PEDIATRIC RESEARCH

Stratification of Culture-Proven Early-Onset Sepsis Cases by the Neonatal Early-Onset Sepsis Calculator: An Individual Patient Data Meta-Analysis

(2021) Niek B. Achten et al.   JOURNAL OF PEDIATRICS

Stratified Management for Bacterial Infections in Late Preterm and Term Neonates: Current Strategies and Future Opportunities Toward Precision Medicine

(2021) Fleur M. Keij et al.   Frontiers in Pediatrics

Biomarkers for the Diagnosis of Neonatal Sepsis

(2021) Joseph B. Cantey et al.   CLINICS IN PERINATOLOGY

Medication Use in the Neonatal Intensive Care Unit and Changes from 2010 to 2018

(2021) Ashley Stark et al.   JOURNAL OF PEDIATRICS

Antibiotic stewardship in NICU: De-implementing routine CRP to reduce antibiotic usage in neonates at risk for early-onset sepsis

(2021) Neetu Singh et al.   Journal of Perinatology

Machine Learning Used to Compare the Diagnostic Accuracy of Risk Factors, Clinical Signs and Biomarkers and to Develop a New Prediction Model for Neonatal Early-onset Sepsis

(2021) Martin Stocker et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Reduction of Duration of Antibiotic Therapy for Suspected Early-Onset Sepsis in Late-Preterm and Term Newborns After Implementation of a Procalcitonin-Guided Algorithm: A Population-Based Study in Central Switzerland

(2021) Jennifer Zihlmann-Ji et al.   Frontiers in Pediatrics

Context and general practitioner decision-making - a scoping review of contextual influence on antibiotic prescribing

(2021) Resha Al-Azzawi et al.   BMC Family Practice

A host signature based on TRAIL, IP-10, and CRP for reducing antibiotic overuse in children by differentiating bacterial from viral infections: a prospective, multicentre cohort study

(2021) Cihan Papan et al.   CLINICAL MICROBIOLOGY AND INFECTION

Noninfectious influencers of early-onset sepsis biomarkers

(2021) Caterina Tiozzo et al.   PEDIATRIC RESEARCH

C-Reactive Protein Testing in Late-Onset Neonatal Sepsis

(2020) Joseph B. Cantey et al.   JAMA Pediatrics

Time to Positivity of Neonatal Blood Cultures for Early-onset Sepsis

(2020) Michael W. Kuzniewicz et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Reduced Antibiotic Exposure by Serial Physical Examinations in Term Neonates at Risk of Early-onset Sepsis

(2020) Anlaug Vatne et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

New reference ranges of procalcitonin excluding respiratory failure in neonates

(2020) Tetsuo Naramura et al.   PEDIATRICS INTERNATIONAL

Sustainability of a Clinical Examination-Based Approach for Ascertainment of Early-Onset Sepsis in Late Preterm and Term Neonates

(2020) Adam Frymoyer et al.   JOURNAL OF PEDIATRICS

C-Reactive Protein, Procalcitonin, and White Blood Count to Rule Out Neonatal Early-onset Sepsis Within 36 Hours: A Secondary Analysis of the Neonatal Procalcitonin Intervention Study

(2020) Martin Stocker et al.   CLINICAL INFECTIOUS DISEASES

Association of Use of the Neonatal Early-Onset Sepsis Calculator With Reduction in Antibiotic Therapy and Safety

(2019) Niek B. Achten et al.   JAMA Pediatrics

Newborn Antibiotic Exposures and Association With Proven Bloodstream Infection

(2019) Joseph Schulman et al.   PEDIATRICS

Serum C-Reactive Protein Levels in Healthy Neonates in Different Gestational and Postnatal Ages

(2018) Sudhakar Palanisamy et al.   JOURNAL OF TROPICAL PEDIATRICS

Culture-Negative Early-Onset Neonatal Sepsis — At the Crossroad Between Efficient Sepsis Care and Antimicrobial Stewardship

(2018) Claus Klingenberg et al.   Frontiers in Pediatrics

Procalcitonin-guided decision making for duration of antibiotic therapy in neonates with suspected early-onset sepsis: a multicentre, randomised controlled trial (NeoPIns)

(2017) Martin Stocker et al.   LANCET

Neonatal sepsis

(2017) Andi L Shane et al.   LANCET

Variation in Sepsis Evaluation Across a National Network of Nurseries

(2017) Sagori Mukhopadhyay et al.   PEDIATRICS

Multi-marker approach using procalcitonin, presepsin, galectin-3, and soluble suppression of tumorigenicity 2 for the prediction of mortality in sepsis

(2017) Hanah Kim et al.   Annals of Intensive Care

Impact of Early-Life Exposures to Infections, Antibiotics, and Vaccines on Perinatal and Long-term Health and Disease

(2017) Steven L. Raymond et al.   Frontiers in Immunology

Variation in Current Management of Term and Late-preterm Neonates at Risk for Early-onset Sepsis

(2016) Wendy van Herk et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Vital signs and their cross-correlation in sepsis and NEC: a study of 1,065 very-low-birth-weight infants in two NICUs

(2016) Karen D. Fairchild et al.   PEDIATRIC RESEARCH

Pros and cons of using biomarkers versus clinical decisions in start and stop decisions for antibiotics in the critical care setting

(2015) Werner C. Albrich et al.   INTENSIVE CARE MEDICINE

NICE neonatal early onset sepsis guidance: greater consistency, but more investigations, and greater length of stay

(2014) Arindam Mukherjee et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Combining Immature and Total Neutrophil Counts to Predict Early Onset Sepsis in Term and Late Preterm Newborns

(2014) Thomas B. Newman et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

A Biomarker Panel (Bioscore) Incorporating Monocytic Surface and Soluble TREM-1 Has High Discriminative Value for Ventilator-Associated Pneumonia: A Prospective Observational Study

(2014) Vimal Grover et al.   PLoS One

Physical Examination Instead of Laboratory Tests for Most Infants Born to Mothers Colonized with Group B Streptococcus: Support for the Centers for Disease Control and Prevention's 2010 Recommendations

(2013) Luigi Cantoni et al.   JOURNAL OF PEDIATRICS

Stratification of Risk of Early-Onset Sepsis in Newborns ≥34 Weeks’ Gestation

(2013) Gabriel J. Escobar et al.   PEDIATRICS

Understanding physician antibiotic prescribing behaviour: a systematic review of qualitative studies

(2012) António Teixeira Rodrigues et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Use of the Complete Blood Cell Count in Early-onset Neonatal Sepsis

(2012) Christoph P. Hornik et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Estimating the Probability of Neonatal Early-Onset Infection on the Basis of Maternal Risk Factors

(2011) K. M. Puopolo et al.   PEDIATRICS

Interpreting Complete Blood Counts Soon After Birth in Newborns at Risk for Sepsis

(2010) T. B. Newman et al.   PEDIATRICS