Prostaglandin E2/EP4 axis is upregulated in Spondyloarthritis and contributes to radiographic progression

Relationship between inflammation and radiographic progression in patients with ankylosing spondylitis attaining a BASDAI of <4 during TNF inhibitor treatment

(2022) Bon San Koo et al.   JOURNAL OF RHEUMATOLOGY

Ankylosing spondylitis: an autoimmune or autoinflammatory disease?

(2021) Daniele Mauro et al.   Nature Reviews Rheumatology

Do smoking and socioeconomic factors influence imaging outcomes in axial spondyloarthritis? Five‐year data from the DESIR cohort

(2020) Elena Nikiphorou et al.   Arthritis & Rheumatology

2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis

(2019) Michael M. Ward et al.   ARTHRITIS CARE & RESEARCH

HLA-B27–mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis

(2019) Chin-Hsiu Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Do NSAIDs affect radiographic progression in axial SpA?

(2019) Jürgen Braun et al.   Nature Reviews Rheumatology

Factors Predictive of Radiographic Progression in Ankylosing Spondylitis

(2019) Ismail Sari et al.   ARTHRITIS CARE & RESEARCH

Translating GWAS in rheumatic disease: approaches to establishing mechanism and function for genetic associations with ankylosing spondylitis

(2018) Julie A Osgood et al.   Briefings in Functional Genomics

Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay

(2018) Ryan Tewhey et al.   CELL

T cell–intrinsic prostaglandin E 2 -EP2/EP4 signaling is critical in pathogenic T H 17 cell–driven inflammation

(2018) Jinju Lee et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prostaglandin E2-EP4 signaling persistently amplifies CD40-mediated induction of IL-23 p19 expression through canonical and non-canonical NF-κB pathways

(2015) Xiaojun Ma et al.   Cellular & Molecular Immunology

Production of prostaglandin E2 induced by cigarette smoke modulates tissue factor expression and activity in endothelial cells

(2015) Patrizia Amadio et al.   FASEB JOURNAL

PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts

(2015) Luis Rodriguez-Rodriguez et al.   ARTHRITIS RESEARCH & THERAPY

Prostaglandin E2 Exerts Catabolic Effects in Osteoarthritis Cartilage: Evidence for Signaling via the EP4 Receptor

(2014) M. Attur et al.   JOURNAL OF IMMUNOLOGY

Evolution of radiographic damage in ankylosing spondylitis: a 12 year prospective follow-up of the OASIS study

(2013) Sofia Ramiro et al.   ANNALS OF THE RHEUMATIC DISEASES

Prostaglandin E2 acts via bone marrow macrophages to block PTH-stimulated osteoblast differentiation in vitro

(2013) Shilpa Choudhary et al.   BONE

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

(2013) Adrian Cortes et al.   NATURE GENETICS

JARID1A, JMY, and PTGER4 Polymorphisms Are Related to Ankylosing Spondylitis in Chinese Han Patients: A Case-Control Study

(2013) Wei Chai et al.   PLoS One

Macrophage phenotype in the subclinical gut inflammation of patients with ankylosing spondylitis

(2013) F. Ciccia et al.   RHEUMATOLOGY

Monocytes Induce STAT3 Activation in Human Mesenchymal Stem Cells to Promote Osteoblast Formation

(2012) Vicky Nicolaidou et al.   PLoS One

Baseline radiographic damage, elevated acute-phase reactant levels, and cigarette smoking status predict spinal radiographic progression in early axial spondylarthritis

(2011) Denis Poddubnyy et al.   ARTHRITIS AND RHEUMATISM

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

The Natural Course of Radiographic Progression in Ankylosing Spondylitis: Differences Between Genders and Appearance of Characteristic Radiographic Features

(2011) Xenofon Baraliakos et al.   Current Rheumatology Reports

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

(2010) John D Reveille et al.   NATURE GENETICS

High-Dose Ketorolac Affects Adult Spinal Fusion

(2010) Quan Li et al.   SPINE

Rescue of Impaired Fracture Healing in COX-2−/− Mice via Activation of Prostaglandin E2 Receptor Subtype 4

(2009) Chao Xie et al.   AMERICAN JOURNAL OF PATHOLOGY

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

(2009) Katia Boniface et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion

(2009) Chengcan Yao et al.   NATURE MEDICINE