Article
Cell Biology
Zhiqi Zhang, Haitao Yu, Wenyan Yao, Na Zhu, Ran Miao, Zhiquan Liu, Xuwei Song, Chunhua Xue, Cheng Cai, Ming Cheng, Ke Lin, Dachuan Qi
Summary: This study reveals that RRP9 plays a critical role in inducing gemcitabine chemoresistance in pancreatic cancer through the activation of the IGF2BP1/AKT signaling pathway.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Cell Biology
Yan Li, Yongying Zhou, Mingliu Huang, Zhen Wang, Daoquan Liu, Jianmin Liu, Xun Fu, Shu Yang, Shidong Shan, Liang Yang, Yuhang Guo, Pengfei Ren, Ping Chen, Guang Zeng, Yuming Guo, Xinghuan Wang, Michael E. DiSanto, Xinhua Zhang
Summary: This study found that 7-dehydrocholesterol reductase (DHCR7) is upregulated in bladder cancer (BCa) and is associated with tumor grade and stage, resulting in poor prognosis. Further investigation revealed that DHCR7 overexpression promotes tumor cell proliferation, inhibits apoptosis, enhances invasion and migration, and induces epithelial-mesenchymal transition (EMT) through the PI3K/AKT/mTOR signaling pathway in vitro and in vivo. DHCR7 deficiency significantly decreases tumorigenesis. These findings suggest that DHCR7 may serve as a potential molecular target for the diagnosis and treatment of BCa.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Hua Yu, Liang Chen, Xia Wang, Feng Tang, Ziyu Wan, Hao Wang, Qiqi Fu, Zhizhuang Chen, Jiageng Shi, Xuan Hu, Yisha Zuhaer, Madanyeti Aersi, Tao Liu, Huangheng Tao, Jianping Peng
Summary: This study investigated the role of STIL in bladder cancer for the first time. The researchers found that STIL is highly expressed in bladder cancer and is closely related to the cell cycle. Knocking out STIL led to a significant delay in the growth rate of bladder cancer cells and arrested the cell cycle in the G0/G1 phase. Mechanistically, STIL enhanced the PI3K/AKT/mTOR pathway, resulting in increased expression of c-myc, ultimately promoting the occurrence and progression of bladder cancer.
Article
Oncology
Runchang Wang, Dongyang Gao, Chaohu Chen, Guangrui Fan, Hui Cheng, Yan Tao, Jianzhong Lu, Junqiang Tian, Yuhan Wang, Zhiping Wang
Summary: ADAM12 plays a critical role in gemcitabine resistance and is positively correlated with malignancy of bladder cancer.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Cell Biology
Huangheng Tao, Yixiang Liao, Youji Yan, Zhiwen He, Jiajie Zhou, Xinghuan Wang, Jianping Peng, Shangze Li, Tao Liu
Summary: This study revealed that high expression of BRCC3 in bladder cancer promotes tumorigenesis by targeting the TRAF2 protein, while genetic ablation of BRCC3 significantly blocks proliferation and migration of bladder cancer cells. RNA-Seq analysis shows down-regulation of NF-kappa B signaling in BRCC3-deficient cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Xu Chen, Zheng-Qian Guo, Dan Cao, Yong Chen, Jian Chen
Summary: The study revealed that overexpression of PNO1 in glioma is associated with poor prognosis, and that PNO1 contributes to glioma progression by activating THBS1/FAK/Akt signaling pathway.
CELL DEATH & DISEASE
(2021)
Article
Genetics & Heredity
Fan Bao, Su An, Yang Yang, Tian-Rui Xu
Summary: SODD is overexpressed in lung tissues and promotes the development and progression of lung cancer by regulating the PI3K/PDK1/AKT and RAF/MEK/ERK signaling pathways.
Article
Chemistry, Multidisciplinary
Jianping Guo, Ji Cheng, Nana Zheng, Xiaomei Zhang, Xiaoming Dai, Linli Zhang, Changjiang Hu, Xueji Wu, Qiwei Jiang, Depei Wu, Hitoshi Okada, Pier Paolo Pandolfi, Wenyi Wei
Summary: Copper activates the PI3K-AKT oncogenic signaling pathway to promote tumorigenesis, while CTR1 is abnormally elevated in breast cancer and regulated by Nedd4l-mediated ubiquitination. Targeting the CTR1-copper node may have therapeutic relevance for hyperactive AKT-driven cancers.
Article
Pharmacology & Pharmacy
Tianli Zhang, Mengmeng Liu, Qing Liu, Gary Guishan Xiao
Summary: Wogonin can enhance the sensitivity of pancreatic cancer cells to gemcitabine chemotherapy, possibly by promoting apoptosis through inhibiting the Akt signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Xiangui Meng, Wen Xiao, Jiayin Sun, Weiquan Li, Hongwei Yuan, Tiexi Yu, Xiaoping Zhang, Wei Dong
Summary: In this study, we identified a novel upregulated circRNA, circPTK2, that regulates bladder cancer (BCa) metastasis and chemoresistance by modulating SETDB1 expression. Through transcriptome analysis, we identified PABPC1 as a novel interacting protein of circPTK2. Our experimental results demonstrated that circPTK2 enhances PABPC1's ability to stabilize SETDB1 mRNA, leading to increased SETDB1 expression and facilitated epithelial-mesenchymal transition (EMT). Functionally, overexpression of the circPTK2-SETDB1 axis promoted migration, invasion, and gemcitabine resistance in vitro and enhanced lymph node metastasis in vivo in BCa cells.
Article
Oncology
Yuanfei Cao, Xin Yan, Xiaojie Bai, Feng Tang, Penghui Si, Can Bai, Kuerban Tuoheti, Linfa Guo, Zuhaer Yisha, Tao Liu, Tongzu Liu
Summary: In this study, UCHL5 was found to promote the growth and migration of bladder cancer cells and increase c-Myc expression by activating the AKT/mTOR signaling pathway. This discovery provides a potential therapeutic target for bladder cancer treatment.
Article
Oncology
Shiyu Tong, Hongling Yin, Jun Fu, Yangle Li
Summary: This study characterized the proteomic profiles of primary and post-IGC recurrent bladder cancer using a label-free proteomics approach, and found that NIBAN1 may regulate FAK signaling activation to promote gemcitabine resistance in bladder cancer. Targeting NIBAN1/FAK signaling may enhance the sensitivity of bladder cancer cells to gemcitabine treatment.
Article
Oncology
Decai Wang, Pu Zhang, Zijian Liu, Yifei Xing', Yajun Xiao
Summary: Bladder cancer is a common malignant tumor of the urinary system, and chemotherapy resistance is a major challenge in its treatment. This study identifies NXPH4 as a novel molecule that plays a role in bladder cancer by affecting cancer cell proliferation, migration, invasion, glycolysis, and gemcitabine resistance. The findings suggest that NXPH4 may provide a new therapeutic angle for bladder cancer.
Article
Medicine, Research & Experimental
Bo Liu, Zhaoqi Liu, Sisi Chen, Michelle Ki, Caroline Erickson, Jorge S. Reis-Filho, Benjamin H. Durham, Qing Chang, Elisa de Stanchina, Yiwei Sun, Raul Rabadan, Omar Abdel-Wahab, Sarat Chandarlapaty
Summary: Hotspot mutations in SF3B1 play a significant role in promoting abnormal splicing in breast cancer, leading to activation of AKT and NF-kappa B signaling pathways, enhanced cell migration, and accelerated tumor development.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Environmental Sciences
Lingling Jiang, Yinglei Liu, Manhua Liu, Yanli Zheng, Liping Chen, Feng Shan, Jinlong Ji, Yang Cao, Haili Kai, Xinyi Kang
Summary: This study explored the effect of REG3A on ovarian cancer progression. REG3A was found to be over-expressed in OC patients and cells, and associated with poor prognosis. REG3A knockdown inhibited proliferation and cisplatin resistance, induced cell cycle arrest and apoptosis of OC cells. Activation of the PI3K/Akt signaling pathway was identified as the mechanism through which REG3A promotes proliferation and cisplatin resistance in OC cells.
ENVIRONMENTAL TOXICOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Rui Cao, Yu Xiao, Xuefeng Liu
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Surgery
Zhiwen He, Siming Chen, Mengxin Lu, Yongwen Luo, Tongzu Liu, Yu Xiao, Xinghuan Wang
Summary: Evaluation of the effectiveness of Enhanced Recovery After Surgery (ERAS) pathway in patients undergoing laparoscopic adrenal resection showed that ERAS can significantly reduce length of hospital stay and medical expenses for patients, but did not show significant differences in surgical complications.
UPDATES IN SURGERY
(2022)
Article
Oncology
Yu Xiao, Lingao Ju, Kaiyu Qian, Wan Jin, Gang Wang, Yan Zhao, Wei Jiang, Nan Liu, Kai Wu, Minsheng Peng, Rui Cao, Sheng Li, Hongjie Shi, Yan Gong, Hang Zheng, Tongzu Liu, Yongwen Luo, Haoli Ma, Luyuan Chang, Gang Li, Xinyue Cao, Ye Tian, Zilin Xu, Zhonghua Yang, Liuying Shan, Zhongqiang Guo, Dongai Yao, Xianlong Zhou, Xintong Chen, Zicheng Guo, Dongmei Liu, Song Xu, Chundong Ji, Fang Yu, Xin Hong, Jun Luo, Hong Cao, Yi Zhang, Xinghuan Wang
Summary: This study found that genome-wide DNAm profile can accurately differentiate between low-grade and high-grade tumors, outperforming genomic mutations or RNA expression profiles. Targeted sequencing can accurately classify non-muscle-invasive bladder cancer tissues from muscle-invasive bladder cancer, and can detect tumors in urine.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Correction
Biochemistry & Molecular Biology
Kaiyu Qian, Gang Wang, Rui Cao, Tao Liu, Guofeng Qian, Xinyuan Guan, Zhongqiang Guo, Yu Xiao, Xinghuan Wang
Article
Biochemistry & Molecular Biology
Wei Liu, Dexin Shen, Lingao Ju, Renjie Zhang, Wenzhi Du, Wan Jin, Kangping Xiong, Gang Wang, Kaiyu Qian, Yi Zhang, Yu Xiao, Xinghuan Wang
Summary: The study reveals that MYBL2 is elevated in bladder cancer and significantly correlated with clinicopathological parameters and patient survival. MYBL2 deficiency suppresses the proliferation and migration of bladder cancer cells, while MYBL2 overexpression promotes these phenotypes. Mechanistically, MYBL2 can bind to the promoter of CDCA3 and activate its transcription, thereby promoting the malignant phenotype of bladder cancer cells. Furthermore, MYBL2 interacts with FOXM1 to co-regulate CDCA3 transcription and activate Wnt/beta-catenin signaling, contributing to the malignant phenotype of bladder cancer.
Article
Cell Biology
Qiong Xiao, Chen-Yu Wang, Chuan Gao, Ji-Dong Chen, Jing-Jing Chen, Zhen Wang, Lin-Gao Ju, Shan-Bo Tang, Jie Yao, Feng Li, Lian-Yun Li, Min Wu
Summary: The study reveals that TRIM11 regulates the tumorigenesis and development of breast cancer by degrading KDM5C, and the expression of TRIM11 is negatively correlated with KDM5C in breast cancer patients.
CELL DEATH & DISEASE
(2022)
Letter
Oncology
Mengxue Yu, Lingao Ju, Xinyue Cao
CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Dexin Shen, Zhao Deng, Wei Liu, Fenfang Zhou, Yayun Fang, Danni Shan, Gang Wang, Kaiyu Qian, Mengxue Yu, Yi Zhang, Lingao Ju, Yu Xiao, Xinghuan Wang
Summary: Melatonin, a natural hormone, has shown potential anticancer effects in various human cancers. In our study, we found that melatonin could inhibit glycolysis and identified ENO1 as a downstream effector and potential biomarker of bladder cancer. We also demonstrated that enhanced glycolysis and gemcitabine resistance could be induced by exogenous pyruvate, and melatonin or ENO1 silencing could enhance the cytotoxic effect of gemcitabine on bladder cancer cells. Furthermore, we discovered that PPAR gamma acted as an upstream regulator of ENO1.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Yejinpeng Wang, Lingao Ju, Gang Wang, Kaiyu Qian, Wan Jin, Mingxing Li, Jingtian Yu, Yiliang Shi, Yongzhi Wang, Yi Zhang, Yu Xiao, Xinghuan Wang
Summary: This study finds that DNA polymerase POLD1 plays a pro-carcinogenic role in bladder cancer and is associated with malignancy and prognosis of bladder cancer. POLD1 promotes proliferation and metastasis of bladder cancer through MYC, stabilizing MYC independently of its DNA polymerase activity and enhancing MYC's transcriptional activity by forming a complex with it. The feedback loop between POLD1 and MYC enhances the pro-carcinogenic effect in bladder cancer.
NATURE COMMUNICATIONS
(2023)
Review
Oncology
Mengxue Yu, Kaiyu Qian, Gang Wang, Yu Xiao, Yuan Zhu, Lingao Ju
Summary: SET domain-containing 2 (SETD2) is a lysine methyltransferase involved in histone modification and has important functions in transcriptional elongation, RNA splicing, and DNA damage repair. SETD2 mutations have been found in various cancers, including clear cell renal cell carcinoma (ccRCC). The deficiency of SETD2 is associated with cancer progression by affecting autophagy flux, metabolic activity, and replication fork speed. Consequently, SETD2 is being investigated as a potential therapeutic target for cancer treatment. This review provides an overview of the molecular functions of SETD2 in H3K36me3 regulation and its relationship with ccRCC, which may pave the way for future antitumor therapies targeting SETD2 or H3K36me3.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Pei Lu, Jie Yang, Mao Li, Shanshan Wen, Tianzhe Zhang, Chenchao Yan, Ran Liu, Yu Xiao, Xinghuan Wang, Wei Jiang
Summary: This study explores the role of a long non-coding RNA (lncRNA), HIDEN, located in a gene desert, in the definitive endoderm differentiation of human pluripotent stem cells. The findings demonstrate that HIDEN facilitates the interaction between IMP1 and FZD5 mRNA, stabilizing FZD5 mRNA levels to activate the WNT signaling pathway and promote human definitive endoderm differentiation.