Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics

Proteolysis targeting chimeras in antiviral research

(2022) Jenny Desantis et al.   Future Medicinal Chemistry

PROTAC targeted protein degraders: the past is prologue

(2022) Miklós Békés et al.   NATURE REVIEWS DRUG DISCOVERY

Discovery of Pentacyclic Triterpenoid PROTACs as a Class of Effective Hemagglutinin Protein Degraders

(2022) Haiwei Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA

(2022) Jianyuan Zhao et al.   Nature Communications

Functional interactomes of the Ebola virus polymerase identified by proximity proteomics in the context of viral replication

(2022) Jingru Fang et al.   Cell Reports

Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host-directed antivirals

(2022) Jingru Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia

(2021) Joshua D. Hansen et al.   JOURNAL OF MEDICINAL CHEMISTRY

TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation

(2021) Jessica Sook Yuin Ho et al.   CELL

Unconventional viral gene expression mechanisms as therapeutic targets

(2021) Jessica Sook Yuin Ho et al.   NATURE

Valspodar limits human cytomegalovirus infection and dissemination

(2021) Andrea J. Parsons et al.   ANTIVIRAL RESEARCH

ORFik: a comprehensive R toolkit for the analysis of translation

(2021) Håkon Tjeldnes et al.   BMC BIOINFORMATICS

Protein degradation: a novel computational approach to design protein degrader probes for main protease of SARS-CoV-2

(2021) Muhammed Shaheer et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Development of a PROTAC-Based Targeting Strategy Provides a Mechanistically Unique Mode of Anti-Cytomegalovirus Activity

(2021) Friedrich Hahn et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection

(2020) Jessica Sook Yuin Ho et al.   CELL

Advances in oligonucleotide drug delivery

(2020) Thomas C. Roberts et al.   NATURE REVIEWS DRUG DISCOVERY

Emerging Pandemic Diseases: How We Got to COVID-19

(2020) David M. Morens et al.   CELL

Modified Nucleic Acids: Expanding the Capabilities of Functional Oligonucleotides

(2020) Steven Ochoa et al.   MOLECULES

CC-90009, a novel cereblon E3 ligase modulator targets acute myeloid leukemia blasts and leukemia stem cells

(2020) Christine Surka et al.   BLOOD

Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations

(2019) Mélissanne de Wispelaere et al.   Nature Communications

eIF2α phosphorylation and the regulation of translation

(2019) Erik Boye et al.   CURRENT GENETICS

Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions

(2019) Luis V Nobre et al.   eLife

Humanized cereblon mice revealed two distinct therapeutic pathways of immunomodulatory drugs

(2018) Yohannes Gemechu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimization of Experimental Parameters in Data-Independent Mass Spectrometry Significantly Increases Depth and Reproducibility of Results

(2017) Roland Bruderer et al.   MOLECULAR & CELLULAR PROTEOMICS

A three-dimensional model of human lung development and disease from pluripotent stem cells

(2017) Ya-Wen Chen et al.   NATURE CELL BIOLOGY

Recognition of Endogenous Nucleic Acids by the Innate Immune System

(2016) Axel Roers et al.   IMMUNITY

Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection

(2016) Nicholas S. Heaton et al.   IMMUNITY

A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

(2016) Mary E. Matyskiela et al.   NATURE

A microRNA-mediated decrease in eukaryotic initiation factor 2α promotes cell survival during PS-341 treatment

(2016) Lili Jiang et al.   Scientific Reports

Broad and potent antiviral activity of the NAE inhibitor MLN4924

(2016) Vu Thuy Khanh Le-Trilling et al.   Scientific Reports

DECIPHER: harnessing local sequence context to improve protein multiple sequence alignment

(2015) Erik S. Wright   BMC BIOINFORMATICS

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

(2015) Jan Krönke et al.   NATURE

Design of a PROTAC that antagonizes and destroys the cancer-forming X-protein of the hepatitis B virus

(2014) Kristopher Montrose et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments

(2014) Meena Choi et al.   BIOINFORMATICS

Anti-Inflammatory Effect of Thalidomide on H1N1 Influenza Virus-Induced Pulmonary Injury in Mice

(2014) Haiyan Zhu et al.   INFLAMMATION

Structure of influenza A polymerase bound to the viral RNA promoter

(2014) Alexander Pflug et al.   NATURE

Emerging Principles for the Therapeutic Exploitation of Glycosylation

(2014) Martin Dalziel et al.   SCIENCE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Evolution of the influenza A virus untranslated regions

(2011) Yuki Furuse et al.   INFECTION GENETICS AND EVOLUTION

Viral subversion of the host protein synthesis machinery

(2011) Derek Walsh et al.   NATURE REVIEWS MICROBIOLOGY

Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers

(2011) S. W. Gerritz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of the Ubiquitin-Proteasome System Affects Influenza A Virus Infection at a Postfusion Step

(2010) I. Widjaja et al.   JOURNAL OF VIROLOGY

Identification of influenza A nucleoprotein as an antiviral target

(2010) Richard Y Kao et al.   NATURE BIOTECHNOLOGY

Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus

(2010) B. Manicassamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Pathology of Influenza Virus Infections

(2008) Jeffery K. Taubenberger et al.   Annual Review of Pathology-Mechanisms of Disease

Chemical Modification of siRNAs for In Vivo Use

(2008) Mark A. Behlke   OLIGONUCLEOTIDES