Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer

Does tissue imprinting restrict macrophage plasticity?

(2021) Martin Guilliams et al.   NATURE IMMUNOLOGY

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells

(2021) María Casanova-Acebes et al.   NATURE

M2 macrophages secrete CXCL13 to promote renal cell carcinoma migration, invasion, and EMT

(2021) Yingwei Xie et al.   Cancer Cell International

The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice

(2020) Birgit Ritschka et al.   GENES & DEVELOPMENT

Blocking the autocrine regulatory loop of Gankyrin/STAT3/CCL24/CCR3 impairs the progression and pazopanib resistance of clear cell renal cell carcinoma

(2020) Chao Wang et al.   Cell Death & Disease

Embracing the dropouts in single-cell RNA-seq analysis

(2020) Peng Qiu   Nature Communications

The role of cellular senescence in ageing and endocrine disease

(2020) Sundeep Khosla et al.   Nature Reviews Endocrinology

Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan

(2020) Laurent Grosse et al.   Cell Metabolism

Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo

(2020) Satotaka Omori et al.   Cell Metabolism

Senescence and the SASP: many therapeutic avenues

(2020) Jodie Birch et al.   GENES & DEVELOPMENT

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

(2020) Raffaella Di Micco et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

(2019) Ilias Angelidis et al.   Nature Communications

Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence

(2019) Jie-Yu Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Short-term gain, long-term pain: the senescence life cycle and cancer

(2019) Adelyne Sue Li Chan et al.   GENES & DEVELOPMENT

M2 macrophages promote NSCLC metastasis by upregulating CRYAB

(2019) Zhe Guo et al.   Cell Death & Disease

M2 macrophage infiltration into tumor islets leads to poor prognosis in non-small-cell lung cancer

(2019) Lili Cao et al.   Cancer Management and Research

Cellular Senescence: Defining a Path Forward

(2019) Vassilis Gorgoulis et al.   CELL

Genetic Deletion of Hesx1 Promotes Exit from the Pluripotent State and Impairs Developmental Diapause

(2019) Sara Pozzi et al.   Stem Cell Reports

Paracrine roles of cellular senescence in promoting tumourigenesis

(2018) Jose Mario Gonzalez-Meljem et al.   BRITISH JOURNAL OF CANCER

c-RAF Ablation Induces Regression of Advanced Kras/Trp 53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling

(2018) Manuel Sanclemente et al.   CANCER CELL

CSF1R inhibition prevents radiation pulmonary fibrosis by depletion of interstitial macrophages

(2018) Lydia Meziani et al.   EUROPEAN RESPIRATORY JOURNAL

Mechanisms and functions of cellular senescence

(2018) Nicolás Herranz et al.   JOURNAL OF CLINICAL INVESTIGATION

scmap: projection of single-cell RNA-seq data across data sets

(2018) Vladimir Yu Kiselev et al.   NATURE METHODS

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

The Dual Role of Bone Morphogenetic Proteins in Cancer

(2018) Duc-Hiep Bach et al.   Molecular Therapy-Oncolytics

The dynamic nature of senescence in cancer

(2018) Soyoung Lee et al.   NATURE CELL BIOLOGY

Massively parallel digital transcriptional profiling of single cells

(2017) Grace X. Y. Zheng et al.   Nature Communications

Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

(2016) Brandon M. Hall et al.   Aging-US

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

MDC and BLC are independently associated with the significant risk of early stage lung adenocarcinoma

(2016) Yanwei Zhang et al.   Oncotarget

CCL24 contributes to HCC malignancy via RhoB- VEGFA-VEGFR2 angiogenesis pathway and indicates poor prognosis

(2016) Lei Jin et al.   Oncotarget

Crosstalk between CCL7 and CCR3 promotes metastasis of colon cancer cells via ERK-JNK signaling pathways

(2016) Yeo Song Lee et al.   Oncotarget

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

The role of senescent cells in ageing

(2014) Jan M. van Deursen   NATURE

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

(2013) Christin E. Burd et al.   CELL

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF

(2013) Martin Guilliams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Circulating Inflammation Markers and Prospective Risk for Lung Cancer

(2013) Meredith S. Shiels et al.   JNCI-Journal of the National Cancer Institute

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

The serum bone morphogenetic protein-2 level in non-small-cell lung cancer patients

(2011) Yoon Ji Choi et al.   MEDICAL ONCOLOGY

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation

(2010) K. P. A. MacDonald et al.   BLOOD

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL