Veklury® (remdesivir) formulations inhibit initial membrane‐coupled events of SARS‐CoV‐2 infection due to their sulfobutylether‐β‐cyclodextrin content

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity

(2022) Bo Meng et al.   NATURE

Structural basis for SARS-CoV-2 Delta variant recognition of ACE2 receptor and broadly neutralizing antibodies

(2022) Yifan Wang et al.   Nature Communications

Simvastatin Downregulates the SARS-CoV-2-Induced Inflammatory Response and Impairs Viral Infection Through Disruption of Lipid Rafts

(2022) Lívia Teixeira et al.   Frontiers in Immunology

Major Update 2: Remdesivir for Adults With COVID-19: A Living Systematic Review and Meta-analysis for the American College of Physicians Practice Points

(2022) Anjum S. Kaka et al.   ANNALS OF INTERNAL MEDICINE

COVID-19 and the promise of small molecule therapeutics: Are there lessons to be learnt?

(2022) Wei Shen Ho et al.   PHARMACOLOGICAL RESEARCH

Planning experiments: Updated guidance on experimental design and analysis and their reporting III

(2022) Michael J. Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

(2022) Brian J. Willett et al.   Nature Microbiology

Cyclodextrins: Only Pharmaceutical Excipients or Full-Fledged Drug Candidates?

(2022) Tamas Kovacs et al.   Pharmaceutics

SARS-CoV-2 infects cells following viral entry via clathrin-mediated endocytosis

(2021) Armin Bayati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19

(2021) Aakriti Gupta et al.   Nature Communications

Membrane Rafts: Portals for Viral Entry

(2021) Inés Ripa et al.   Frontiers in Microbiology

Targeting Lipid Rafts as a Strategy Against Coronavirus

(2021) Maurizio Sorice et al.   Frontiers in Cell and Developmental Biology

Statin‐boosted cellular uptake and endosomal escape of penetratin due to reduced membrane dipole potential

(2021) Gyula Batta et al.   BRITISH JOURNAL OF PHARMACOLOGY

An ω-3, but Not an ω-6 Polyunsaturated Fatty Acid Decreases Membrane Dipole Potential and Stimulates Endo-Lysosomal Escape of Penetratin

(2021) Florina Zakany et al.   Frontiers in Cell and Developmental Biology

Renal and Hepatic Toxicity Analysis of Remdesivir Formulations: Does What Is on the Inside Really Count?

(2021) Sunish Shah et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

(2021) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Introduction and Other Protein Targets

(2021) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sulfobutylether-beta-cyclodextrin-enabled antiviral remdesivir: Characterization of electrospun- and lyophilized formulations

(2021) Lajos Szente et al.   CARBOHYDRATE POLYMERS

Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial

(2021) Florence Ader et al.   LANCET INFECTIOUS DISEASES

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

(2021) Delphine Planas et al.   NATURE

The total number and mass of SARS-CoV-2 virions

(2021) Ron Sender et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular Life Cycle Kinetics of SARS-CoV-2 Predicted Using Mathematical Modelling

(2021) Dmitry Grebennikov et al.   Viruses-Basel

Modeling Within-Host Dynamics of SARS-CoV-2 Infection: A Case Study in Ferrets

(2021) Naveen K. Vaidya et al.   Viruses-Basel

Clinical drug therapies and biologicals currently used or in clinical trial to treat COVID-19

(2021) Rory J. Malek et al.   BIOMEDICINE & PHARMACOTHERAPY

Mechanisms of SARS-CoV-2 entry into cells

(2021) Cody B. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients

(2021) Robert L. Gottlieb et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comment on “Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2”

(2021) Michael A. Martin et al.   Science Translational Medicine

Cholesterol-Rich Lipid Rafts as Platforms for SARS-CoV-2 Entry

(2021) Selvin Noé Palacios-Rápalo et al.   Frontiers in Immunology

Cyclodextrins Exert a Ligand-like Current Inhibitory Effect on the KV1.3 Ion Channel Independent of Membrane Cholesterol Extraction

(2021) Tamas Kovacs et al.   Frontiers in Molecular Biosciences

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection

(2020) Emmie de Wit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

(2020) Timothy P. Sheahan et al.   Nature Communications

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)

(2020) James M. Sanders et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Tao Guo et al.   JAMA Cardiology

Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

(2020) Ka-Tim Choy et al.   ANTIVIRAL RESEARCH

Direct and indirect cholesterol effects on membrane proteins with special focus on potassium channels

(2020) Florina Zakany et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Safety, Tolerability, and Pharmacokinetics of Remdesivir, An Antiviral for Treatment of COVID‐19, in Healthy Subjects

(2020) Rita Humeniuk et al.   CTS-Clinical and Translational Science

The Lord of the NanoRings: cyclodextrins and the battle against SARS-CoV-2

(2020) Pablo F. Garrido et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

(2020) Brandi N. Williamson et al.   NATURE

Factors associated with COVID-19-related death using OpenSAFELY

(2020) Elizabeth J. Williamson et al.   NATURE

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

(2020) Andrea J. Pruijssers et al.   Cell Reports

Coronavirus Interplay With Lipid Rafts and Autophagy Unveils Promising Therapeutic Targets

(2020) Katia Fecchi et al.   Frontiers in Microbiology

Relation of Statin Use Prior to Admission to Severity and Recovery Among COVID-19 Inpatients

(2020) Lori B. Daniels et al.   AMERICAN JOURNAL OF CARDIOLOGY

Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19

(2020) Christoph D. Spinner et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Structures and distributions of SARS-CoV-2 spike proteins on intact virions

(2020) Zunlong Ke et al.   NATURE

Investigating the Mechanism of Cyclodextrins in the Treatment of Niemann‐Pick Disease Type C Using Crosslinked 2‐Hydroxypropyl‐β‐cyclodextrin

(2020) Dario Carradori et al.   Small

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

2-Hydroxypropyl-β-cyclodextrin is the active component in a triple combination formulation for treatment of Niemann-Pick C1 disease

(2019) Jessica Davidson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Clinical Pharmacokinetics of Sulfobutylether-β-Cyclodextrin in Patients With Varying Degrees of Renal Impairment

(2018) Randall K. Hoover et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Cyclodextrins: Assessing the Impact of Cavity Size, Occupancy, and Substitutions on Cytotoxicity and Cholesterol Homeostasis

(2018) Lajos Szente et al.   MOLECULES

The dipole potential correlates with lipid raft markers in the plasma membrane of living cells

(2017) Tamás Kovács et al.   JOURNAL OF LIPID RESEARCH

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

(2017) Dustin Siegel et al.   JOURNAL OF MEDICINAL CHEMISTRY

The mystery of membrane organization: composition, regulation and roles of lipid rafts

(2017) Erdinc Sezgin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

(2017) Timothy P. Sheahan et al.   Science Translational Medicine

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

(2016) Travis K. Warren et al.   NATURE

Efficacy and ototoxicity of different cyclodextrins in Niemann-Pick C disease

(2016) Cristin D. Davidson et al.   Annals of Clinical and Translational Neurology

Efficacy of 2-Hydroxypropyl-β-cyclodextrin in Niemann–Pick Disease Type C Model Mice and Its Pharmacokinetic Analysis in a Patient with the Disease

(2015) Yuta Tanaka et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Analysis of the K+ current in human CD4+ T lymphocytes in hypercholesterolemic state

(2013) Sándor Somodi et al.   CELLULAR IMMUNOLOGY

Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

(2012) Aesop Cho et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pharmaceutical applications of cyclodextrins: basic science and product development

(2010) Thorsteinn Loftsson et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Cyclodextrins

(2008) Valentino J. Stella et al.   TOXICOLOGIC PATHOLOGY