Fully human monoclonal antibody targeting activated ADAM10 on colorectal cancer cells

A highly-specific fully-human antibody and CAR-T cells targeting CD66e/CEACAM5 are cytotoxic for CD66e-expressing cancer cells in vitro and in vivo

(2021) Du-San Baek et al.   CANCER LETTERS

Inhibitory monoclonal antibody targeting ADAM17 expressed on cancer cells

(2021) Nayanendu Saha et al.   Translational Oncology

Targeting ADAM10 in Cancer and Autoimmunity

(2020) Timothy M. Smith et al.   Frontiers in Immunology

ADAM proteases: Emerging role and targeting of the non-catalytic domains

(2019) Nayanendu Saha et al.   CANCER LETTERS

Notch1 is a prognostic factor that is distinctly activated in the classical and proneural subtype of glioblastoma and that promotes glioma cell survival via the NF-κB(p65) pathway

(2018) Long Hai et al.   Cell Death & Disease

Cancer stem cells in colorectal cancer: a review

(2017) Matthew J Munro et al.   JOURNAL OF CLINICAL PATHOLOGY

An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth

(2016) Lakmali Atapattu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non-EGFR-Mediated Pathways

(2015) J. Rios-Doria et al.   MOLECULAR CANCER THERAPEUTICS

Targeting the Sheddase Activity of ADAM17 by an Anti-ADAM17 Antibody D1(A12) Inhibits Head and Neck Squamous Cell Carcinoma Cell Proliferation and Motility via Blockage of Bradykinin Induced HERs Transactivation

(2014) Yanchao Huang et al.   International Journal of Biological Sciences

Therapeutic modulation of Notch signalling — are we there yet?

(2014) Emma R. Andersson et al.   NATURE REVIEWS DRUG DISCOVERY

Early Detection of Colorectal Cancer Recurrence in Patients Undergoing Surgery with Curative Intent: Current Status and Challenges

(2014) Patrick. E. Young et al.   Journal of Cancer

Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells

(2013) Cindy R. Timme et al.   APOPTOSIS

Activity of ADAM17 (a Disintegrin and Metalloprotease 17) Is Regulated by Its Noncatalytic Domains and Secondary Structure of its Substrates

(2013) Roma Stawikowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells

(2012) Kosuke Yamamoto et al.   BIOCHEMICAL JOURNAL

Suppression of Acquired Docetaxel Resistance in Prostate Cancer through Depletion of Notch- and Hedgehog-Dependent Tumor-Initiating Cells

(2012) Josep Domingo-Domenech et al.   CANCER CELL

Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function

(2012) L. Atapattu et al.   JOURNAL OF CELL SCIENCE

Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy

(2012) S. M. McAuliffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects

(2012) Casper Groth et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

(2011) J.-L. Li et al.   CANCER RESEARCH

Notch: Implications of endogenous inhibitors for therapy

(2010) Ivan Dikic et al.   BIOESSAYS

Anti-DLL4 Inhibits Growth and Reduces Tumor-Initiating Cell Frequency in Colorectal Tumors with Oncogenic KRAS Mutations

(2010) M. Fischer et al.   CANCER RESEARCH

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

(2010) Paul Saftig et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

ADAM 10 is associated with gastric cancer progression and prognosis of patients

(2010) Yuan-Yu Wang et al.   JOURNAL OF SURGICAL ONCOLOGY

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2

(2010) K. Salaita et al.   SCIENCE

 -Secretase Inhibitors Abrogate Oxaliplatin-Induced Activation of the Notch-1 Signaling Pathway in Colon Cancer Cells Resulting in Enhanced Chemosensitivity

(2009) R. D. Meng et al.   CANCER RESEARCH

Cytoplasmic Relaxation of Active Eph Controls Ephrin Shedding by ADAM10

(2009) Peter W. Janes et al.   PLOS BIOLOGY

Current perspective of TACE inhibitors: A review

(2008) Shirshendu DasGupta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Host cell recognition by the henipaviruses: Crystal structures of the Nipah G attachment glycoprotein and its complex with ephrin-B3

(2008) K. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA