An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth

Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium

(2015) K. Horvay et al.   EMBO JOURNAL

A gp130–Src–YAP module links inflammation to epithelial regeneration

(2015) Koji Taniguchi et al.   NATURE

Angiocrine Factors Deployed by Tumor Vascular Niche Induce B Cell Lymphoma Invasiveness and Chemoresistance

(2014) Zhongwei Cao et al.   CANCER CELL

The Cancer Stem Cell Marker Aldehyde Dehydrogenase Is Required to Maintain a Drug-Tolerant Tumor Cell Subpopulation

(2014) D. Raha et al.   CANCER RESEARCH

Eph- and ephrin-dependent mechanisms in tumor and stem cell dynamics

(2014) Erika Gucciardo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ADAM10 Regulates Notch Function in Intestinal Stem Cells of Mice

(2014) Yu-Hwai Tsai et al.   GASTROENTEROLOGY

The role of proteases in regulating Eph/ephrin signaling

(2014) Lakmali Atapattu et al.   Cell Adhesion & Migration

Endothelial Cells Promote the Colorectal Cancer Stem Cell Phenotype through a Soluble Form of Jagged-1

(2013) Jia Lu et al.   CANCER CELL

Mechanisms Governing Metastatic Dormancy and Reactivation

(2013) Filippo G. Giancotti   CELL

mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice

(2013) Stefan Thiem et al.   JOURNAL OF CLINICAL INVESTIGATION

Membrane-Proximal Domain of a Disintegrin and Metalloprotease-17 Represents the Putative Molecular Switch of Its Shedding Activity Operated by Protein-disulfide Isomerase

(2013) Stefan Düsterhöft et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function

(2013) Jaehong Suh et al.   NEURON

Alterations in Gene Expression of Proprotein Convertases in Human Lung Cancer Have a Limited Number of Scenarios

(2013) Ilya V. Demidyuk et al.   PLoS One

Who decides when to cleave an ectodomain?

(2013) Monika Hartmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

(2013) Lucio Miele et al.   OncoTargets and Therapy

Antibodies binding the ADAM10 substrate recognition domain inhibit Eph function

(2012) L. Atapattu et al.   JOURNAL OF CELL SCIENCE

Furin Overexpression Suppresses Tumor Growth and Predicts a Better Postoperative Disease-Free Survival in Hepatocellular Carcinoma

(2012) Ya-Hui Huang et al.   PLoS One

Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects

(2012) Casper Groth et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Protein Disulfide Isomerase Family: Key Players in Health and Disease

(2011) Adam M. Benham   ANTIOXIDANTS & REDOX SIGNALING

Dual Processing of FAT1 Cadherin Protein by Human Melanoma Cells Generates Distinct Protein Products

(2011) Elham Sadeqzadeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eph receptor function is modulated by heterooligomerization of A and B type Eph receptors

(2011) Peter W. Janes et al.   JOURNAL OF CELL BIOLOGY

Labile disulfide bonds are common at the leucocyte cell surface

(2011) C. Metcalfe et al.   Open Biology

Thiol isomerases negatively regulate the cellular shedding activity of ADAM17

(2010) Sofie H. Willems et al.   BIOCHEMICAL JOURNAL

Notch: Implications of endogenous inhibitors for therapy

(2010) Ivan Dikic et al.   BIOESSAYS

Anti-DLL4 Inhibits Growth and Reduces Tumor-Initiating Cell Frequency in Colorectal Tumors with Oncogenic KRAS Mutations

(2010) M. Fischer et al.   CANCER RESEARCH

Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling

(2010) Hyun Ae Woo et al.   CELL

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

(2010) Paul Saftig et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

(2010) S. M. Le Gall et al.   JOURNAL OF CELL SCIENCE

NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon

(2010) Nicolas Coant et al.   MOLECULAR AND CELLULAR BIOLOGY

Detection of single-molecule H2O2 signalling from epidermal growth factor receptor using fluorescent single-walled carbon nanotubes

(2010) Hong Jin et al.   Nature Nanotechnology

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Regulation of Mature ADAM17 by Redox Agents for L-Selectin Shedding

(2009) Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Structures of two elapid snake venom metalloproteases with distinct activities highlight the disulfide patterns in the D domain of ADAMalysin family proteins

(2009) Hong-Hsiang Guan et al.   JOURNAL OF STRUCTURAL BIOLOGY

Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells

(2009) M R Finkbeiner et al.   ONCOGENE

Cytoplasmic Relaxation of Active Eph Controls Ephrin Shedding by ADAM10

(2009) Peter W. Janes et al.   PLOS BIOLOGY

Current perspective of TACE inhibitors: A review

(2008) Shirshendu DasGupta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Ca2+-Binding Capacity of Epidermal Furin Is Disrupted by H2O2-Mediated Oxidation in Vitiligo

(2008) J. D. Spencer et al.   ENDOCRINOLOGY

The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer

(2008) Jessica Pruessmeyer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY