The anticancer effect of PASylated calreticulin-targeting L-ASNase in solid tumor bearing mice with immunogenic cell death-inducing chemotherapy

Immunogenic cell stress and death

(2022) Guido Kroemer et al.   NATURE IMMUNOLOGY

Novel Insights on the Use of L-Asparaginase as an Efficient and Safe Anti-Cancer Therapy

(2022) Maaike Van Trimpont et al.   Cancers

Calreticulin—Multifunctional Chaperone in Immunogenic Cell Death: Potential Significance as a Prognostic Biomarker in Ovarian Cancer Patients

(2021) Michal Kielbik et al.   Cells

Therapeutic enzymes: Discoveries, Production and Applications

(2021) Siddhi Tandon et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Imaging calreticulin for early detection of immunogenic cell death during anticancer treatment

(2021) Dong-Yeon Kim et al.   JOURNAL OF NUCLEAR MEDICINE

Integrated Lab-Scale Process Combining Purification and PEGylation of l-Asparaginase from Zymomonas mobilis

(2021) Jose Ramon et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Amino acid metabolism as a therapeutic target in cancer: a review

(2021) Molly Endicott et al.   AMINO ACIDS

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Engineering Calreticulin-Targeting Monobodies to Detect Immunogenic Cell Death in Cancer Chemotherapy

(2021) Ying Zhang et al.   Cancers

FDA-Approved Drugs for Hematological Malignancies—The Last Decade Review

(2021) Aleksandra Sochacka-Ćwikła et al.   Cancers

A Targeted Catalytic Nanobody (T-CAN) with Asparaginolytic Activity

(2021) Maristella Maggi et al.   Cancers

Monobodies as enabling tools for structural and mechanistic biology

(2020) Oliver Hantschel et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure-Function Relationship of Inclusion Bodies of a Multimeric Protein

(2020) Anupam Singh et al.   Frontiers in Microbiology

Targeting immunogenic cell death in cancer

(2020) Asma Ahmed et al.   Molecular Oncology

Recent Strategies and Applications for l-Asparaginase Confinement

(2020) João C. F. Nunes et al.   MOLECULES

The nuclear factor kappa B (NF-κB) signaling pathway is involved in ammonia-induced mitochondrial dysfunction

(2020) Aida Adlimoghaddam et al.   MITOCHONDRION

Enhancing bioactivity, physicochemical, and pharmacokinetic properties of a nano-sized, anti-VEGFR2 Adnectin, through PASylation technology

(2019) Safieh Aghaabdollahian et al.   Scientific Reports

Pegaspargase: A Review in Acute Lymphoblastic Leukaemia

(2019) Young-A. Heo et al.   DRUGS

Prospects of PASylation® for the design of protein and peptide therapeutics with extended half-life and enhanced action

(2018) Michaela Gebauer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cell mass-dependent expression of an anticancer protein drug by tumor-targeted Salmonella

(2018) Kwangsoo Kim et al.   Oncotarget

Affibody-functionalized Ag2S quantum dots for photoacoustic imaging of epidermal growth factor receptor overexpressed tumors

(2018) Ying Zhang et al.   Nanoscale

Ecto-Calreticulin is essential for an efficient immunogenic cell death stimulation in mouse melanoma

(2018) Paola Giglio et al.   GENES AND IMMUNITY

Weight Loss During Initial Chemotherapy Predicts Survival in Patients With Advanced Gastric Cancer

(2017) Kotoe Takayoshi et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: A report from the Children's Oncology Group

(2017) Rachel E. Rau et al.   PEDIATRIC BLOOD & CANCER

Engineering of monobody conjugates for human EphA2-specific optical imaging

(2017) Min-A Kim et al.   PLoS One

PASylated Coversin, a C5-Specific Complement Inhibitor with Extended Pharmacokinetics, Shows Enhanced Anti-Hemolytic Activity in Vitro

(2016) Nadine Kuhn et al.   BIOCONJUGATE CHEMISTRY

Current applications and different approaches for microbial l-asparaginase production

(2016) Jorge Javier Muso Cachumba et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

A Comprehensive Review on l-Asparaginase and Its Applications

(2015) Tahira Batool et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Therapeuticl-asparaginase: upstream, downstream and beyond

(2015) André Moreni Lopes et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhanced in Vivo Efficacy

(2015) Volker Morath et al.   MOLECULAR PHARMACEUTICS

L-Asparaginase delivered by Salmonella typhimurium suppresses solid tumors

(2015) Kwangsoo Kim et al.   Molecular Therapy-Oncolytics

Phase 2 study of CT-322, a targeted biologic inhibitor of VEGFR-2 based on a domain of human fibronectin, in recurrent glioblastoma

(2014) David Schiff et al.   INVESTIGATIONAL NEW DRUGS

PEG-asparaginase allergy in children with acute lymphoblastic leukemia in the NOPHO ALL2008 protocol

(2014) Louise Tram Henriksen et al.   PEDIATRIC BLOOD & CANCER

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Asparagine synthetase: regulation by cell stress and involvement in tumor biology

(2013) Mukundh N. Balasubramanian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Acute lymphoblastic leukaemia

(2013) Hiroto Inaba et al.   LANCET

PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins

(2013) M. Schlapschy et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

Beneficial effects of curcumin on antitumor activity and adverse reactions of doxorubicin

(2012) Yasuyuki Sadzuka et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

State of the art in PEGylation: The great versatility achieved after forty years of research

(2011) Gianfranco Pasut et al.   JOURNAL OF CONTROLLED RELEASE

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

Twelve immunotherapy drugs that could cure cancers

(2008) Martin A. ‘Mac’ Cheever   IMMUNOLOGICAL REVIEWS