Involvement of aquaporin 5 in Sjögren’s syndrome

Insight into the Mammalian Aquaporin Interactome

(2022) Susanna Törnroth-Horsefield et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lysosome-associated membrane protein 3 misexpression in salivary glands induces a Sjögren’s syndrome-like phenotype in mice

(2021) Hiroyuki Nakamura et al.   ANNALS OF THE RHEUMATIC DISEASES

Ezrin Is a Novel Protein Partner of Aquaporin-5 in Human Salivary Glands and Shows Altered Expression and Cellular Localization in Sjögren’s Syndrome

(2021) Clara Chivasso et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Salivary Gland Tissue Engineering Approaches: State of the Art and Future Directions

(2021) Lindsay R. Piraino et al.   Cells

Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in primary Sjögren's syndrome

(2021) Lei Huang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Treatment of Sjögren’s Syndrome with Mesenchymal Stem Cells: A Systematic Review

(2021) Najwa Chihaby et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Keeping an eye on Ca2+ signalling to tackle dry eye diseases

(2021) Flore Sneyers et al.   EBioMedicine

Application of regenerative medicine to salivary gland hypofunction

(2021) Junichi Tanaka et al.   Japanese Dental Science Review

Mouth-Watering Results: Clinical Need, Current Approaches, and Future Directions for Salivary Gland Regeneration

(2020) Cecilia Rocchi et al.   TRENDS IN MOLECULAR MEDICINE

Current State of Knowledge on Primary Sjögren’s Syndrome, an Autoimmune Exocrinopathy

(2020) Dorian Parisis et al.   Journal of Clinical Medicine

Insight into Salivary Gland Aquaporins

(2020) Claudia D’Agostino et al.   Cells

Keratoconjunctivitis Sicca in Sjögren’s Syndrome

(2020) Yutong Su et al.   NEW ENGLAND JOURNAL OF MEDICINE

AQP2: Mutations Associated with Congenital Nephrogenic Diabetes Insipidus and Regulation by Post-Translational Modifications and Protein-Protein Interactions

(2020) Chao Gao et al.   Cells

Assessment of mucin-related gene alterations following treatment with rebamipide ophthalmic suspension in Sjögren’s syndrome-associated dry eyes

(2020) Jun Shoji et al.   PLoS One

Cell adhesion molecules’ altered profile in benign and malignant salivary gland tumors. The paradigm of beta4-integrin, desmoglein-2, ICAM-1 and CD44s

(2020) Dimitrios Andreadis et al.   Journal of Biological Research-Thessaloniki

Mesenchymal Stem Cell Enhances the Function of MDSCs in Experimental Sjögren Syndrome

(2020) Jie Tian et al.   Frontiers in Immunology

Renal Disease in Primary Sjögren’s Syndrome

(2020) Oshorenua Aiyegbusi et al.   Rheumatology and Therapy

Blockade of CD40–CD154 pathway interactions suppresses ectopic lymphoid structures and inhibits pathology in the NOD/ShiLtJ mouse model of Sjögren’s syndrome

(2019) Grazyna Wieczorek et al.   ANNALS OF THE RHEUMATIC DISEASES

LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I

(2019) Huifang Xian et al.   Autophagy

Risk of Wnt/β-catenin signalling pathway gene polymorphisms in primary Sjögren’s syndrome

(2019) Javier Fernández-Torres et al.   RHEUMATOLOGY

Aberrant MUC1 accumulation in salivary glands of Sjögren’s syndrome patients is reversed by TUDCA in vitro

(2019) Isabel Castro et al.   RHEUMATOLOGY

Anti-IL-7 receptor-α treatment ameliorates newly established Sjögren's-like exocrinopathy in non-obese diabetic mice

(2018) Jing Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Disruption of endothelial barrier function is linked with hyposecretion and lymphocytic infiltration in salivary glands of Sjögren's syndrome

(2018) Xin Cong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pilocarpine and artificial saliva for the treatment of xerostomia and xerophthalmia in Sjögren syndrome: a double-blind randomized controlled trial

(2018) M. Cifuentes et al.   BRITISH JOURNAL OF DERMATOLOGY

FGF2-dependent mesenchyme and laminin-111 are niche factors in salivary gland organoids

(2018) Zeinab F. Hosseini et al.   JOURNAL OF CELL SCIENCE

Update on Sjögren Syndrome and Other Causes of Sicca in Older Adults

(2018) Alan N. Baer et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application

(2018) Mengyuan Wang et al.   Stem Cells International

Effect of bone morphogenetic protein 6 on immunomodulatory functions of salivary gland-derived mesenchymal stem cells in Sjögren’s Syndrome

(2018) Junji Xu et al.   STEM CELLS AND DEVELOPMENT

Carbonic anhydrase 12 mutation modulates membrane stability and volume regulation of aquaporin 5

(2018) Soyoung Hwang et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Primary Sjögren's syndrome

(2018) SJ Bowman   LUPUS

Correction of Ductal CFTR Activity Rescues Acinar Cell and Pancreatic and Salivary Gland Functions in Mouse Models of Autoimmune Disease

(2017) Mei Zeng et al.   GASTROENTEROLOGY

The Role of Aquaporins in Ocular Lens Homeostasis

(2017) Kevin Schey et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional Epitopes for Anti–Aquaporin 5 Antibodies in Sjögren Syndrome

(2017) J. Alam et al.   JOURNAL OF DENTAL RESEARCH

Pathogenic role of endogenous TNF-α in the development of Sjögren’s-like sialadenitis and secretory dysfunction in non-obese diabetic mice

(2017) Jing Zhou et al.   LABORATORY INVESTIGATION

Vasoactive Intestinal Peptide Protects Salivary Glands against Structural Injury and Secretory Dysfunction via IL-17A and AQP5 Regulation in a Model of Sjögren Syndrome

(2017) Chengyin Li et al.   NEUROIMMUNOMODULATION

Antibodies to aquaporins are frequent in patients with primary Sjögren’s syndrome

(2017) John S. Tzartos et al.   RHEUMATOLOGY

Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren’s Syndrome

(2017) Hema S. Aluri et al.   Stem Cells International

Detection of Autoantibodies against Aquaporin-1 in the Sera of Patients with Primary Sjögren's Syndrome

(2017) Jehan Alam et al.   Immune Network

Investigation of age-related changes in the expression of aquaporin-1 and aquaporin-5 in the salivary glands of mice

(2016) Emrah Sapmaz et al.   ACTA OTO-LARYNGOLOGICA

Role of flotillins in the endocytosis of GPCR in salivary gland epithelial cells

(2016) Moon-Yong Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aquaporin-5: from structure to function and dysfunction in cancer

(2016) Inês Direito et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Late responses to adenoviral-mediated transfer of the aquaporin-1 gene for radiation-induced salivary hypofunction

(2016) I Alevizos et al.   GENE THERAPY

Adenovirus-mediated hAQP1 expression in irradiated mouse salivary glands causes recovery of saliva secretion by enhancing acinar cell volume decrease

(2016) L Y Teos et al.   GENE THERAPY

Detection of autoantibodies against aquaporin-5 in the sera of patients with primary Sjögren’s syndrome

(2016) Jehan Alam et al.   IMMUNOLOGIC RESEARCH

Interleukin-17 Impairs Salivary Tight Junction Integrity in Sjögren’s Syndrome

(2016) L.W. Zhang et al.   JOURNAL OF DENTAL RESEARCH

Abnormal distribution of AQP5 in labial salivary glands is associated with poor saliva secretion in patients with Sjögren's syndrome including neuromyelitis optica complicated patients

(2016) Shunsuke Yoshimura et al.   Modern Rheumatology

Aquaporin gene therapy corrects Sjögren’s syndrome phenotype in mice

(2016) Zhennan Lai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted trophic factors of mesenchymal stem cells support neurovascular and musculoskeletal therapies

(2016) Heidi R. Hofer et al.   Stem Cell Research & Therapy

Biomaterials-based strategies for salivary gland tissue regeneration

(2016) Tugba Ozdemir et al.   Biomaterials Science

Endogenous programmed death ligand-1 restrains the development and onset of Sjӧgren’s syndrome in non-obese diabetic mice

(2016) Jing Zhou et al.   Scientific Reports

Ultrasound-assisted nonviral gene transfer of AQP1 to the irradiated minipig parotid gland restores fluid secretion

(2015) Z Wang et al.   GENE THERAPY

Stem Cell–Soluble Signals Enhance Multilumen Formation in SMG Cell Clusters

(2015) C.L.M. Maruyama et al.   JOURNAL OF DENTAL RESEARCH

Effect of Antimuscarinic Autoantibodies in Primary Sjögren’s Syndrome

(2015) N. Kim et al.   JOURNAL OF DENTAL RESEARCH

Physiological role of aquaporin 5 in salivary glands

(2015) Kazuo Hosoi   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

IP3R deficit underlies loss of salivary fluid secretion in Sjögren’s Syndrome

(2015) Leyla Y. Teos et al.   Scientific Reports

Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways

(2015) Philip Kitchen et al.   PLoS One

Zonula Occludens-1, Occludin and E-cadherin Expression and Organization in Salivary Glands with Sjögren’s Syndrome

(2014) Rachel E. Mellas et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Mice Lacking Inositol 1,4,5-Trisphosphate Receptors Exhibit Dry Eye

(2014) Takaaki Inaba et al.   PLoS One

X-ray structure of human aquaporin 2 and its implications for nephrogenic diabetes insipidus and trafficking

(2014) A. Frick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal stem cells: a new trend for cell therapy

(2013) Xin Wei et al.   ACTA PHARMACOLOGICA SINICA

Actin directly interacts with different membrane channel proteins and influences channel activities: AQP2 as a model

(2013) Sei Sasaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Aquaporins in salivary glands and pancreas

(2013) Christine Delporte   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Interleukin-8 Regulates Endothelial Permeability by Down-regulation of Tight Junction but not Dependent on Integrins Induced Focal Adhesions

(2013) Hongchi Yu et al.   International Journal of Biological Sciences

Sjögren's syndrome and the epithelial target: A comprehensive review

(2013) M.J. Barrera et al.   JOURNAL OF AUTOIMMUNITY

Immunolocalization and translocation of aquaporin-5 water channel in sweat glands

(2013) Risako Inoue et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The Gating Mechanism of the Human Aquaporin 5 Revealed by Molecular Dynamics Simulations

(2013) Lorant Janosi et al.   PLoS One

Functional salivary gland regeneration by transplantation of a bioengineered organ germ

(2013) Miho Ogawa et al.   Nature Communications

Salivary Gland Dysfunction and Xerostomia in Sjögren's Syndrome

(2013) Siri Beier Jensen et al.   Oral and Maxillofacial Surgery Clinics of North America

Extraglandular Manifestations of Primary Sjögren's Syndrome

(2013) Sabatino Ienopoli et al.   Oral and Maxillofacial Surgery Clinics of North America

AnIn VitroCulture System for Long-Term Expansion of Epithelial and Mesenchymal Salivary Gland Cells: Role of TGF-β1 in Salivary Gland Epithelial and Mesenchymal Differentiation

(2013) Kajohnkiart Janebodin et al.   Biomed Research International

Function of the Membrane Water Channel Aquaporin-5 in the Salivary Gland

(2012) Toshiyuki Matsuzaki et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

Allogeneic mesenchymal stem cell treatment alleviates experimental and clinical Sjogren syndrome

(2012) J. Xu et al.   BLOOD

Link between inflammation and aquaporin-5 distribution in submandibular gland in sjögren’s syndrome?

(2012) MS Soyfoo et al.   ORAL DISEASES

E2f1-deficient NOD/SCID mice have dry mouth due to a change of acinar/duct structure and the down-regulation of AQP5 in the salivary gland

(2012) Keitaro Satoh et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Abnormal subcellular localization of AQP5 and downregulated AQP5 protein in parotid glands of streptozotocin-induced diabetic rats

(2011) Di Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Prevention of Radiation-Induced Salivary Hypofunction Following hKGF Gene Delivery to Murine Submandibular Glands

(2011) C. Zheng et al.   CLINICAL CANCER RESEARCH

Dendrobium officinale polysaccharides ameliorate the abnormality of aquaporin 5, pro-inflammatory cytokines and inhibit apoptosis in the experimental Sjögren's syndrome mice

(2011) Xiang Lin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

TNF-α inhibits aquaporin 5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation

(2011) Yoshiko Yamamura et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Localization of AQP5 during development of the mouse submandibular salivary gland

(2011) Helga S. Larsen et al.   JOURNAL OF MOLECULAR HISTOLOGY

TACI-Fc gene therapy improves autoimmune sialadenitis but not salivary gland function in non-obese diabetic mice

(2011) JL Vosters et al.   ORAL DISEASES

Potential Down-Regulation of Salivary Gland AQP5 by LPS via Cross-Coupling of NF-κB and p-c-Jun/c-Fos

(2010) Chenjuan Yao et al.   AMERICAN JOURNAL OF PATHOLOGY

Disruption of tight junction structure in salivary glands from Sjögren's syndrome patients is linked to proinflammatory cytokine exposure

(2010) Patricia Ewert et al.   ARTHRITIS AND RHEUMATISM

AAV2-mediated transfer of the human aquaporin-1 cDNA restores fluid secretion from irradiated miniature pig parotid glands

(2010) R Gao et al.   GENE THERAPY

IL17: potential therapeutic target in Sjögren's syndrome using adenovirus-mediated gene transfer

(2010) Cuong Q Nguyen et al.   LABORATORY INVESTIGATION

Aberrant localization of ezrin correlates with salivary acini disorganization in Sjögren’s Syndrome

(2010) Paola Pérez et al.   RHEUMATOLOGY

Matrigel Improves Functional Properties of Primary Human Salivary Gland Cells

(2010) Ola M. Maria et al.   TISSUE ENGINEERING PART A

Altered Distribution of Aquaporin 5 and its C-Terminal Binding Protein in the Lacrimal Glands of a Mouse Model for Sjögren's Syndrome

(2009) Yoshiki Ohashi et al.   CURRENT EYE RESEARCH

Mechanisms involved in the therapeutic properties of mesenchymal stem cells

(2009) Lindolfo da Silva Meirelles et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Differential gene expression in the salivary gland during development and onset of xerostomia in Sjögren's syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse

(2009) Cuong Q Nguyen et al.   ARTHRITIS RESEARCH & THERAPY

Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking

(2008) Yumi Noda et al.   JOURNAL OF CELL BIOLOGY

High-resolution x-ray structure of human aquaporin 5

(2008) R. Horsefield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA