Mechanism of Radical Initiation in the Radical SAM Enzyme Superfamily

Mechanism of Radical S-Adenosyl-l-methionine Adenosylation: Radical Intermediates and the Catalytic Competence of the 5′-Deoxyadenosyl Radical

(2022) Maike N. Lundahl et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization by ENDOR Spectroscopy of the Iron–Alkyl Bond in a Synthetic Counterpart of Organometallic Intermediates in Radical SAM Enzymes

(2022) Madeline B. Ho et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure–function relationships of radical SAM enzymes

(2020) Yvain Nicolet   Nature Catalysis

Viperin: an ancient radical-SAM enzyme finds its place in modern cellular metabolism and innate immunity

(2020) Soumi Ghosh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Radical SAM Enzyme Spore Photoproduct Lyase: Properties of the Ω Organometallic Intermediate and Identification of Stable Protein Radicals Formed during Substrate-Free Turnover

(2020) Adrien Pagnier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

S ‐Adenosyl‐ l ‐ethionine is a Catalytically Competent Analog of S ‐Adenosyl‐ l ‐methione (SAM) in the Radical SAM Enzyme HydG

(2020) Stella Impano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Active-Site Controlled, Jahn–Teller Enabled Regioselectivity in Reductive S–C Bond Cleavage of S-Adenosylmethionine in Radical SAM Enzymes

(2020) Stella Impano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Elusive 5′-Deoxyadenosyl Radical: Captured and Characterized by Electron Paramagnetic Resonance and Electron Nuclear Double Resonance Spectroscopies

(2019) Hao Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photoinduced Electron Transfer in a Radical SAM Enzyme Generates an S-Adenosylmethionine Derived Methyl Radical

(2019) Hao Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trapping and Electron Paramagnetic Resonance Characterization of the 5′dAdo• Radical in a Radical S-Adenosyl Methionine Enzyme Reaction with a Non-Native Substrate

(2019) Richard I. Sayler et al.   ACS Central Science

Paradigm Shift for Radical S-Adenosyl-l-methionine Reactions: The Organometallic Intermediate Ω Is Central to Catalysis

(2018) Amanda S. Byer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C–C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products

(2018) Kenichi Yokoyama et al.   NATURAL PRODUCT REPORTS

Mechanism of Radical Initiation in the Radical S-Adenosyl-l-methionine Superfamily

(2018) William E. Broderick et al.   ACCOUNTS OF CHEMICAL RESEARCH

The radical-SAM enzyme Viperin catalyzes reductive addition of a 5′-deoxyadenosyl radical to UDP-glucose in vitro

(2017) Kourosh Honarmand Ebrahimi et al.   FEBS LETTERS

Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme

(2017) Krista A. Shisler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The photochemistry and photobiology of vitamin B12

(2017) Alex R. Jones   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Radical SAM Enzymes in the Biosynthesis of Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs)

(2017) Alhosna Benjdia et al.   Frontiers in Chemistry

Carbon–sulfur bond-forming reaction catalysed by the radical SAM enzyme HydE

(2016) Roman Rohac et al.   Nature Chemistry

Radical SAM catalysis via an organometallic intermediate with an Fe-[5'-C]-deoxyadenosyl bond

(2016) M. Horitani et al.   SCIENCE

Energy Cascades, Excited State Dynamics, and Photochemistry in Cob(III)alamins and Ferric Porphyrins

(2015) Aaron S. Rury et al.   ACCOUNTS OF CHEMICAL RESEARCH

Why Nature Uses Radical SAM Enzymes so Widely: Electron Nuclear Double Resonance Studies of Lysine 2,3-Aminomutase Show the 5′-dAdo• “Free Radical” Is Never Free

(2015) Masaki Horitani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RadicalS-Adenosyl Methionine Epimerases: Regioselective Introduction of DiverseD-Amino Acid Patterns into Peptide Natural Products

(2014) Brandon I. Morinaka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Radical S-Adenosylmethionine Enzymes

(2014) Joan B. Broderick et al.   CHEMICAL REVIEWS

Characterization of Protein Contributions to Cobalt−Carbon Bond Cleavage Catalysis in Adenosylcobalamin-Dependent Ethanolamine Ammonia-Lyase by using Photolysis in the Ternary Complex

(2011) Wesley D. Robertson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

S K-edge XAS and DFT Calculations on SAM Dependent Pyruvate Formate-Lyase Activating Enzyme: Nature of Interaction between the Fe4S4Cluster and SAM and its Role in Reactivity

(2011) Abhishek Dey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

[FeFe]-Hydrogenase Cyanide Ligands Derived From S-Adenosylmethionine-Dependent Cleavage of Tyrosine

(2010) Rebecca C. Driesener et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pyruvate Formate-lyase, Evidence for an Open Conformation Favored in the Presence of Its Activating Enzyme

(2010) Yi Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

[FeFe]-Hydrogenase Maturation: HydG-Catalyzed Synthesis of Carbon Monoxide

(2010) Eric M. Shepard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photolysis of Adenosylcobalamin and Radical Pair Recombination in Ethanolamine Ammonia-Lyase Probed on the Micro- to Millisecond Time Scale by Using Time-Resolved Optical Absorption Spectroscopy†

(2008) Wesley D. Robertson et al.   BIOCHEMISTRY

Structural basis for glycyl radical formation by pyruvate formate-lyase activating enzyme

(2008) J. L. Vey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA