Article
Reproductive Biology
Yoshifumi Mori, Narumi Ogonuki, Ayumi Hasegawa, Mito Kanatsu-Shinohara, Atsuo Ogura, Yufeng Wang, John R. McCarrey, Takashi Shinohara
Summary: The study shows that Ogg1 is essential for protecting SSCs from ROS-induced damage, by increasing the expression of base excision repair-related genes to safeguard SSCs against DNA damage caused by ROS.
BIOLOGY OF REPRODUCTION
(2021)
Review
Biochemistry & Molecular Biology
Weiran Zhang, Ranwei Zhong, Xiangping Qu, Yang Xiang, Ming Ji
Summary: Excess reactive oxygen species (ROS) can lead to oxidative stress by disrupting the balance between oxidation and anti-oxidation. The main product of ROS-induced base damage is 8-hydroxyguanine (8-oxoG), which can cause mutations if not promptly removed during DNA replication. The OGG1-mediated oxidative damage repair pathway plays an important role in preventing dysfunction caused by oxidative stress.
Article
Biochemistry & Molecular Biology
Ekaterina A. Yurchenko, Ekaterina S. Menchinskaya, Evgeny A. Pislyagin, Ekaterina A. Chingizova, Elena Girich, Anton N. Yurchenko, Dmitry L. Aminin, Valery V. Mikhailov
Summary: The compounds from Aspergillus candidus KMM 4676 and Penicillium islandicum (=Talaromyces islandicus) showed protective effects against neurotoxins rotenone and paraquat in Neuro-2a cells, increasing cell viability. The study discussed the structure-activity relationships for p-terphenyl derivatives and possible mechanisms of cytoprotective action of all compounds.
Article
Biochemistry & Molecular Biology
Bishoy M. F. Hanna, Maurice Michel, Thomas Helleday, Oliver Mortusewicz
Summary: DNA damage caused by reactive oxygen species can lead to genetic mutations or cell death, and base excision repair is a major pathway for repairing such damage. This study demonstrates that NEIL1 and NEIL2 can potentially serve as backup BER enzymes for OGG1 in the presence of pharmacological inhibition or depletion of OGG1, indicating a prospective compensatory role for NEIL1 and NEIL2 in maintaining genomic integrity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biology
Vijayalaxmi, Kenneth Foster
Summary: This review examines over 300 papers published in the past three decades on the genotoxic effects of exposure to radiofrequency electromagnetic fields (RF-EMF) on human and animal tissues. The authors find that while most studies showed no statistically significant effects, a minority of studies reported significant effects, particularly in vivo studies. The quality of the studies varied greatly, with only a few complying with accepted guidelines for genotoxicity testing. The authors recommend that future studies adhere to these guidelines and emphasize the need for a thorough evaluation of study validity and coherence with related studies.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Liangliang Tao, Xiucai Fan, Jin Sun, Zhu Zhang
Summary: Metformin can reduce high glucose-induced endothelial reactive oxygen species generation by upregulating OGG1. Furthermore, the stability of OGG1 protein expression is related to mRNA stability, which can be reversed by genetic inhibition of AMPK alpha and Lin-28.
Article
Environmental Sciences
Yeganeh Koohestanidehaghi, Mohammad Ali Khalili, Farzaneh Fesahat, Mohammad Seify, Esmat Mangoli, Seyed Mehdi Kalantar, Stefania Annarita Nottola, Guido Macchiarelli, Maria Grazia Palmerini
Summary: This study investigated the effects of mobile phone RF-EMR on mouse embryo development and genetic toxicity. Results showed that exposure to RF-EMR led to delayed cleavage development and a longer time to reach the blastocyst stage. It also caused changes in the transcript levels of oxidative stress associated genes.
ENVIRONMENTAL POLLUTION
(2023)
Review
Environmental Sciences
Stefania Romeo, Olga Zeni, Anna Sannino, Susanna Lagorio, Mauro Biffoni, Maria Rosaria Scarfi
Summary: This article outlines a protocol for a systematic review of experimental studies investigating genotoxic effects induced by RF-EMF in in vitro cellular models. The study will follow guidelines from NTP-OHAT and will include experimental in vitro studies addressing the relationship between controlled exposures to RF-EMF and genotoxicity in mammalian cells.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Cell Biology
Ugo Cappucci, Assunta Maria Casale, Mirena Proietti, Fiorenzo Marinelli, Livio Giuliani, Lucia Piacentini
Summary: Exposure to artificial radio frequency electromagnetic fields (RF-EMFs) has increased in recent years, leading to a growing interest in understanding their biological impact. This study investigated the non-thermal effects of low-level indoor RF-EMF exposure from WiFi wireless technologies on Drosophila melanogaster. The results showed that WiFi radiation caused chromatin decondensation and loss of epigenetic silencing in both germinal and neural tissues, as well as accumulation of reactive oxygen species, genomic instability, and behavioral abnormalities. Additionally, WiFi radiation synergized with Ras(V12) to promote tumor progression and invasion.
Article
Chemistry, Analytical
Marco Xavier Rivera Gonzalez, Nazario Felix Gonzalez, Isabel Lopez, Juan Sebastian Ochoa Zambrano, Andres Miranda Martinez, Ceferino Maestu Unturbe
Summary: A novel compact device with spectrum analyzer characteristics has been designed to measure the entire communications spectrum and detect multiple sources of electromagnetic fields. The device was calibrated in an anechoic chamber for far-fields and validated against a portable spectrum analyzer in a residential area, showing a strong correlation with a confidence higher than 95%. This indicates that the device could be considered as an important tool for electromagnetic field studies.
Article
Microbiology
Mayura Veerana, Nan-Nan Yu, Si-Jin Bae, Ikhwan Kim, Eun-Seong Kim, Wirinthip Ketya, Hak-Yong Lee, Nam-Young Kim, Gyungsoon Park
Summary: This study demonstrates that exposure to a specific radio-frequency electromagnetic field can enhance the production of the enzyme alpha-amylase in a filamentous fungus, leading to increased protein concentration and activity. The exposure also affects the intracellular calcium level and transcription of genes involved in protein cellular trafficking.
Article
Chemistry, Physical
Marta Multigner, Irene Morales, Marta Munoz, Victoria Bonache, Fernando Giacomone, Patricia de la Presa, Rosario Benavente, Belen Torres, Diego Mantovani, Joaquin Rams
Summary: In this study, magnetic nanoparticles were used to enhance the properties of polylactic acid, with the aim of modifying the polymer structure by heating the reinforcing MNPs under radiofrequency electromagnetic fields. The nanocomposites showed increased crystallinity, hardness, and elastic modulus with EMF treatment.
Article
Biochemistry & Molecular Biology
Valtteri Nieminen, Miina Juntunen, Jonne Naarala, Jukka Luukkonen
Summary: The study evaluated the effect of static or 50 Hz magnetic fields on the response of human MCF-7 breast cancer cells to the chemotherapeutic agent doxorubicin. The results showed that static magnetic fields decreased DNA damage induced by doxorubicin, while 50 Hz magnetic fields increased cytosolic superoxide levels induced by doxorubicin.
BIOELECTROCHEMISTRY
(2022)
Article
Thermodynamics
Sadiq M. Sait, Syed Faraz Ahmed, Muhammad Rahil Rafiq
Summary: The study measured and documented the maximum level of broadband radiofrequency electromagnetic radiations in the vicinity of cellular base stations in different regions of the Kingdom of Saudi Arabia. It found that urban areas had higher radiation levels compared to rural areas, with the broadband radiation levels compliant with international standards.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Article
Nutrition & Dietetics
Katarzyna Domaszewska, Agnieszka Zawada, Radoslaw Palutka, Tomasz Podgorski, Aldona Juchacz
Summary: This study aimed to determine the effect of using an oxygen-enriched breathing mixture during controlled physical training on blood oxidative stress parameters and total phenolics concentrations in obese adult women. The results showed that increasing the concentration of oxygen in the respiratory mixture during exercise was safe and did not exacerbate oxidative stress in the obese group.