Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Genetics & Heredity
Lei Gu, Anmao Li, Jing Lin, Yiling Gan, Chunyan He, Rui Xiao, Jiaxin Liao, Yishi Li, Shuliang Guo
Summary: This study investigated the role of SOX9 in the regulation of tracheal fibrosis. The results showed that SOX9 was upregulated in tracheal injury and fibrosis, and inhibiting SOX9 could attenuate tracheal fibrosis progression.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Xuran Li, Tongtong Zhang, Wenting Lv, Hui Wang, Haoran Chen, Qinghua Xu, Hourong Cai, Jinghong Dai
Summary: Polystyrene microplastics (PS-MPs) are absorbed by organisms and affect cellular functions due to their small volume and biological permeability. Inhalation of PS-MPs has been found to induce pulmonary fibrosis in mice, accompanied by oxidative stress and activation of the Wnt/β-catenin signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Endocrinology & Metabolism
Liya Shi, Xue Xue, Hui Tian, Hongjuan Ye, Hui Wang, Rongxiang Wang, Yu Liu, Caixia Zhang, Qiuju Chen, Lihua Sun
Summary: Endometriosis, common in women of childbearing age, involves the presence of endometrial tissue outside the uterine cavity. Research shows that WEE1 promotes migration and fibrosis in endometrial stromal cells through the Wnt/β-catenin signaling pathway, suggesting it may be a potential therapeutic target for endometriosis treatment.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Xiao-Yong Yu, Qian Sun, Ya-Mei Zhang, Liang Zou, Ying-Yong Zhao
Summary: This review summarizes the role of TGF-beta/Smad signaling pathway in tubulointerstitial fibrosis and natural products that target this pathway for the treatment of fibrosis. Additionally, it presents challenges and opportunities for inhibiting renal fibrosis in the future.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Shan-Shan Li, Qian Sun, Meng-Ru Hua, Ping Suo, Jia-Rong Chen, Xiao-Yong Yu, Ying-Yong Zhao
Summary: The Wnt/β-catenin signaling pathway is crucial in renal fibrosis, controlling downstream mediators in various cell types and interacting with other pathways to promote fibrosis. Blocking this pathway may be beneficial for fibrosis treatment. Antagonists of Wnt signaling and small-molecule β-catenin inhibitors show potential therapeutic effects in preventing and treating renal fibrosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Zheng Qin, Yupei Li, Jiameng Li, Luojia Jiang, Zhuyun Zhang, Kaixi Chang, Qinbo Yang, Shanshan Chen, Ruoxi Liao, Baihai Su
Summary: This study found that exosomal STAT1 derived from HP-treated HUVECs can promote VSMC calcification. Activation of the Wnt/beta-catenin pathway may be a potential mechanism of exosome-promoted VSMC calcification.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Chemistry, Medicinal
Yuecheng Jiang, Xin Lin, Yan Mao, Jianqiu Zhao, Guihua Zhang, Jiali Yu, Rong Dong, Yan Zha
Summary: The study found that acteoside (ACT) can inhibit renal fibrosis in unilateral ureteral obstruction (UUO) rats, probably by inhibiting the beta-catenin/CTGF signaling pathway.
NATURAL PRODUCT COMMUNICATIONS
(2022)
Article
Plant Sciences
Mingming Zhao, Bin Yang, Liusheng Li, Yuan Si, Meiying Chang, Sijia Ma, Ronghai Li, Yuejun Wang, Yu Zhang
Summary: This study demonstrates that MHCD can alleviate renal fibrosis in rats with IgA nephropathy by reducing the expression levels of fibronectin, laminin, and collagen IV in renal tissues.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xinbing Yang, Yajing Du, Lulu Luo, Xinru Xu, Shizheng Xiong, Xueni Yang, Li Guo, Tingming Liang
Summary: Dysregulated expression of specific non-coding RNAs (ncRNAs) has been strongly linked to tumorigenesis, cancer progression, and therapeutic resistance. Recent evidence suggests that ncRNAs can interact with the Wnt/beta-catenin signaling pathway, influencing the expression of Wnt target genes in cancer cells. This review aims to unravel the complex associations between ncRNAs and the Wnt/beta-catenin signaling pathway and explore their potential implications for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Xiaobin Shang, Kai Oliver Boeker, Shahed Taheri, Thelonius Hawellek, Wolfgang Lehmann, Arndt F. Schilling
Summary: Osteoarthritis is a chronic disease that lacks disease-modifying treatment, with the Wnt/beta-catenin pathway playing a key role in its pathophysiology. Both excessive stimulation and suppression of this pathway can contribute to the development of OA. MicroRNAs have been found to regulate various cellular processes in different diseases, offering potential insights for the development of miRNA-based therapeutics for OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Fengge Liu, Xiangfeng Kong, Hui Kong
Summary: The study revealed that subconjunctival fibrosis induced by ethylparaben is the result of extra extracellular matrix generation by conjunctival fibroblasts via the Wnt/beta-catenin axis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Tingting Lin, Jiaqi Tao, Ying Chen, Yitong Zhang, Fenglan Li, Yutong Zhang, Xueqing Han, Zihui Zhao, Guiyan Liu, Hui Li
Summary: This study demonstrated that selenium deficiency can lead to kidney damage and renal fibrosis, and established that the Wnt/beta-catenin pathway, related to selenium deficiency, may play a significant role in renal fibrosis.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
