Structure–Activity Relationships for Psilocybin, Baeocystin, Aeruginascin, and Related Analogues to Produce Pharmacological Effects in Mice

Diversity, biology, and history of psilocybin-containing fungi: Suggestions for research and technological development

(2022) R.C. Van Court et al.   Fungal Biology

In vitro assays for the functional characterization of (psychedelic) substances at the serotonin receptor 5‐HT 2A R

(2022) Eline Pottie et al.   JOURNAL OF NEUROCHEMISTRY

Structure-based discovery of nonhallucinogenic psychedelic analogs

(2022) Dongmei Cao et al.   SCIENCE

Gs signaling pathway distinguishes hallucinogenic and nonhallucinogenic 5-HT2AR agonists induced head twitch response in mice

(2022) Xiaoqian Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetic survey of Psilocybe natural products

(2022) Sebastian Dörner et al.   CHEMBIOCHEM

Tentative identification of in vitro metabolites of O ‐acetylpsilocin (psilacetin, 4‐AcO‐DMT) by UHPLC‐Q‐Orbitrap MS

(2022) Wenya Zhai et al.   Drug Testing and Analysis

The promises and perils of psychedelic pharmacology for psychiatry

(2022) Tristan D. McClure-Begley et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis, Structural Characterization, and Pharmacological Activity of Novel Quaternary Salts of 4-Substituted Tryptamines

(2022) Grant C. Glatfelter et al.   ACS Omega

Serotonin 5-HT2A, 5-HT2c and 5-HT1A receptor involvement in the acute effects of psilocybin in mice. In vitro pharmacological profile and modulation of thermoregulation and head-twich response

(2022) I. Erkizia-Santamaría et al.   BIOMEDICINE & PHARMACOTHERAPY

Psychedelics as preventive treatment in headache and chronic pain disorders

(2022) Emmanuelle A.D. Schindler   NEUROPHARMACOLOGY

LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1

(2021) Ramona M. Rodriguiz et al.   Scientific Reports

Molecular insights into psychedelic drug action

(2021) Samuel T. Slocum et al.   JOURNAL OF NEUROCHEMISTRY

Structure-activity relationships for 5F-MDMB-PICA and its 5F-pentylindole analogs to induce cannabinoid-like effects in mice

(2021) Grant C. Glatfelter et al.   NEUROPSYCHOPHARMACOLOGY

A qualitative descriptive analysis of effects of psychedelic phenethylamines and tryptamines

(2020) Joseph J. Palamar et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Prodrugs of New Psychoactive Substances (NPS): A New Challenge

(2020) Simon P. Elliott et al.   JOURNAL OF FORENSIC SCIENCES

Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin

(2020) Alexander M. Sherwood et al.   JOURNAL OF NATURAL PRODUCTS

Psilocybin: from ancient magic to modern medicine

(2020) David E. Nichols   JOURNAL OF ANTIBIOTICS

Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species

(2020) Adam L. Halberstadt et al.   NEUROPHARMACOLOGY

In vitro structure–activity relationship determination of 30 psychedelic new psychoactive substances by means of β-arrestin 2 recruitment to the serotonin 2A receptor

(2020) Eline Pottie et al.   ARCHIVES OF TOXICOLOGY

Subjective features of the psilocybin experience that may account for its self-administration by humans: a double-blind comparison of psilocybin and dextromethorphan

(2020) Theresa M. Carbonaro et al.   PSYCHOPHARMACOLOGY

The Current Status of Psychedelics in Psychiatry

(2020) David Nutt et al.   JAMA Psychiatry

Active Metabolite of Aeruginascin (4-Hydroxy-N,N,N-trimethyltryptamine): Synthesis, Structure, and Serotonergic Binding Affinity

(2020) Andrew R. Chadeayne et al.   ACS Omega

Affinity, potency, efficacy, selectivity, and molecular modeling of substituted fentanyls at opioid receptors

(2020) Amy J. Eshleman et al.   BIOCHEMICAL PHARMACOLOGY

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

(2020) Kuglae Kim et al.   CELL

Identification of psychedelic new psychoactive substances (NPS) showing biased agonism at the 5-HT2AR through simultaneous use of β-arrestin 2 and miniGαq bioassays

(2020) Eline Pottie et al.   BIOCHEMICAL PHARMACOLOGY

A non-hallucinogenic psychedelic analogue with therapeutic potential

(2020) Lindsay P. Cameron et al.   NATURE

A Dendrite-Focused Framework for Understanding the Actions of Ketamine and Psychedelics

(2020) Neil K. Savalia et al.   TRENDS IN NEUROSCIENCES

Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels

(2019) Martin K. Madsen et al.   NEUROPSYCHOPHARMACOLOGY

Simultaneous Production of Psilocybin and a Cocktail of β‐Carboline Monoamine Oxidase Inhibitors in “Magic” Mushrooms

(2019) Felix Blei et al.   CHEMISTRY-A EUROPEAN JOURNAL

DARK Classics in Chemical Neuroscience: Psilocybin

(2018) Haden A. Geiger et al.   ACS Chemical Neuroscience

Monoamine Transporter and Receptor Interaction Profiles in Vitro Predict Reported Human Doses of Novel Psychoactive Stimulants and Psychedelics

(2018) Dino Luethi et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

High dose psilocybin is associated with positive subjective effects in healthy volunteers

(2018) Christopher R Nicholas et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Comparative neuropharmacology of N -(2-methoxybenzyl)-2,5-dimethoxyphenethylamine (NBOMe) hallucinogens and their 2C counterparts in male rats

(2018) Joshua S. Elmore et al.   NEUROPHARMACOLOGY

Receptor binding profiles and behavioral pharmacology of ring-substituted N , N -diallyltryptamine analogs

(2018) Landon M. Klein et al.   NEUROPHARMACOLOGY

Neurochemical pharmacology of psychoactive substituted N-benzylphenethylamines: high potency agonists at 5-HT2A receptors

(2018) Amy J Eshleman et al.   BIOCHEMICAL PHARMACOLOGY

Identification of ω-N-Methyl-4-hydroxytryptamine (Norpsilocin) as a Psilocybe Natural Product

(2017) Claudius Lenz et al.   JOURNAL OF NATURAL PRODUCTS

Double-blind comparison of the two hallucinogens psilocybin and dextromethorphan: similarities and differences in subjective experiences

(2017) Theresa M. Carbonaro et al.   PSYCHOPHARMACOLOGY

Sex differences and serotonergic mechanisms in the behavioural effects of psilocin

(2016) Filip Tylš et al.   BEHAVIOURAL PHARMACOLOGY

Psychedelics as Medicines: An Emerging New Paradigm

(2016) DE Nichols et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Modulatory effect of the 5-HT1A agonist buspirone and the mixed non-hallucinogenic 5-HT1A/2A agonist ergotamine on psilocybin-induced psychedelic experience

(2016) Thomas Pokorny et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens

(2016) Anna Rickli et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Survey study of challenging experiences after ingesting psilocybin mushrooms: Acute and enduring positive and negative consequences

(2016) Theresa M Carbonaro et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Behavioral and pharmacokinetic interactions between monoamine oxidase inhibitors and the hallucinogen 5-methoxy-N,N-dimethyltryptamine

(2016) Adam L. Halberstadt   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells

(2015) Andrew S. Dixon et al.   ACS Chemical Biology

N-Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT2 Receptor Family Agonists and Comparison with a Series of Phenethylamine Analogues

(2015) David E. Nichols et al.   ACS Chemical Neuroscience

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

(2015) Wesley K Kroeze et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interaction of psychoactive tryptamines with biogenic amine transporters and serotonin receptor subtypes

(2014) Bruce E. Blough et al.   PSYCHOPHARMACOLOGY

Substituted methcathinones differ in transporter and receptor interactions

(2013) Amy J. Eshleman et al.   BIOCHEMICAL PHARMACOLOGY

Activation of Serotonin 2A Receptors Underlies the Psilocybin-Induced Effects on   Oscillations, N170 Visual-Evoked Potentials, and Visual Hallucinations

(2013) M. Kometer et al.   JOURNAL OF NEUROSCIENCE

Signalling bias in new drug discovery: detection, quantification and therapeutic impact

(2013) Terry Kenakin et al.   NATURE REVIEWS DRUG DISCOVERY

Effects of Schedule I drug laws on neuroscience research and treatment innovation

(2013) David J. Nutt et al.   NATURE REVIEWS NEUROSCIENCE

Characterization of the head-twitch response induced by hallucinogens in mice

(2013) Adam L. Halberstadt et al.   PSYCHOPHARMACOLOGY

Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model

(2012) Clint E. Canal et al.   Drug Testing and Analysis

Behavioral effects of α,α,β,β-tetradeutero-5-MeO-DMT in rats: comparison with 5-MeO-DMT administered in combination with a monoamine oxidase inhibitor

(2012) Adam L. Halberstadt et al.   PSYCHOPHARMACOLOGY

Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens

(2011) Adam L. Halberstadt et al.   NEUROPHARMACOLOGY

Functional interactions between 5-HT2A and presynaptic 5-HT1A receptor-based responses in mice genetically deficient in the serotonin 5-HT transporter (SERT)

(2010) Meredith A Fox et al.   BRITISH JOURNAL OF PHARMACOLOGY

Serotonin, But Not N-Methyltryptamines, Activates the Serotonin 2A Receptor Via a  -Arrestin2/Src/Akt Signaling Complex In Vivo

(2010) C. L. Schmid et al.   JOURNAL OF NEUROSCIENCE

Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice

(2010) Adam L Halberstadt et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies

(2010) Erich Studerus et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Psychedelics and the Human Receptorome

(2010) Thomas S. Ray   PLoS One

Agonist-directed signaling of the serotonin 2A receptor depends on  -arrestin-2 interactions in vivo

(2008) C. L. Schmid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hallucinogens as discriminative stimuli in animals: LSD, phenethylamines, and tryptamines

(2008) J. C. Winter   PSYCHOPHARMACOLOGY

Structure and Function of the Third Intracellular Loop of the 5-Hydroxytryptamine2A Receptor: The Third Intracellular Loop Is α-Helical and Binds Purified Arrestins

(2003) Edward I. Gelber et al.   JOURNAL OF NEUROCHEMISTRY