The intestinal epithelium as guardian of gut barrier integrity

Humoral Immunity in the Gut Selectively Targets Phenotypically Virulent Attaching-and-Effacing Bacteria for Intraluminal Elimination

(2015) Nobuhiko Kamada et al.   Cell Host & Microbe

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

(2015) Robert O. Watson et al.   Cell Host & Microbe

The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus

(2015) Yue Zhao et al.   IMMUNOLOGICAL REVIEWS

New developments in goblet cell mucus secretion and function

(2015) G M H Birchenough et al.   Mucosal Immunology

Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation

(2015) Clara Moon et al.   NATURE

A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis

(2015) Bappaditya Dey et al.   NATURE MEDICINE

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

(2014) Marta Wlodarska et al.   CELL

Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa

(2014) Mikael E. Sellin et al.   Cell Host & Microbe

Epithelial IL-22RA1-Mediated Fucosylation Promotes Intestinal Colonization Resistance to an Opportunistic Pathogen

(2014) Tu Anh N. Pham et al.   Cell Host & Microbe

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

(2014) Leigh A. Knodler et al.   Cell Host & Microbe

EnteropathogenicE. colieffectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration

(2014) Lila G. Glotfelty et al.   CELLULAR MICROBIOLOGY

Listeria monocytogenes induces IFN  expression through an IFI16-, cGAS- and STING-dependent pathway

(2014) K. Hansen et al.   EMBO JOURNAL

The composition of the gut microbiota shapes the colon mucus barrier

(2014) H. E. Jakobsson et al.   EMBO REPORTS

Correlation Between Intraluminal Oxygen Gradient and Radial Partitioning of Intestinal Microbiota

(2014) Lindsey Albenberg et al.   GASTROENTEROLOGY

Intestinal mucus affinity and biological activity of an orally administered antibacterial and anti-inflammatory peptide

(2014) Aline Dupont et al.   GUT

The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria

(2014) Judith Behnsen et al.   IMMUNITY

Intestinal Epithelium-Specific MyD88 Signaling Impacts Host Susceptibility to Infectious Colitis by Promoting Protective Goblet Cell and Antimicrobial Responses

(2014) Ganive Bhinder et al.   INFECTION AND IMMUNITY

Enteropathogenic Escherichia coli Inhibits Type I Interferon- and RNase L-Mediated Host Defense To Disrupt Intestinal Epithelial Cell Barrier Function

(2014) Tiha M. Long et al.   INFECTION AND IMMUNITY

TRIF Signaling Drives Homeostatic Intestinal Epithelial Antimicrobial Peptide Expression

(2014) Silvia Stockinger et al.   JOURNAL OF IMMUNOLOGY

The DNA Sensor, Cyclic GMP–AMP Synthase, Is Essential for Induction of IFN-β duringChlamydia trachomatisInfection

(2014) Yugen Zhang et al.   JOURNAL OF IMMUNOLOGY

Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide

(2014) B O Schroeder et al.   Mucosal Immunology

Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

(2014) Joseph M. Pickard et al.   NATURE

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

(2014) Nozomi Takahashi et al.   NATURE

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

(2014) Marius Dannappel et al.   NATURE

Quantitative Assessment of Cytosolic Salmonella in Epithelial Cells

(2014) Leigh A. Knodler et al.   PLoS One

Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells

(2014) Susanna R. Bidgood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

(2014) Y. Goto et al.   SCIENCE

Absence of Intestinal PPARγ Aggravates Acute Infectious Colitis in Mice through a Lipocalin-2–Dependent Pathway

(2014) Parag Kundu et al.   PLoS Pathogens

Age-Dependent Enterocyte Invasion and Microcolony Formation by Salmonella

(2014) Kaiyi Zhang et al.   PLoS Pathogens

Intestinal Epithelial Autophagy Is Essential for Host Defense against Invasive Bacteria

(2013) Jamaal L. Benjamin et al.   Cell Host & Microbe

Intraluminal Containment of Commensal Outgrowth in the Gut during Infection-Induced Dysbiosis

(2013) Michael J. Molloy et al.   Cell Host & Microbe

Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice From Salmonella Infection

(2013) Kara L. Conway et al.   GASTROENTEROLOGY

Luminal Bacteria Recruit CD103+ Dendritic Cells into the Intestinal Epithelium to Sample Bacterial Antigens for Presentation

(2013) Julia Farache et al.   IMMUNITY

The Mucin Muc2 Limits Pathogen Burdens and Epithelial Barrier Dysfunction during Salmonella enterica Serovar Typhimurium Colitis

(2013) Maryam Zarepour et al.   INFECTION AND IMMUNITY

Human colonic mucus is a reservoir for antimicrobial peptides

(2013) Lena Antoni et al.   Journal of Crohns & Colitis

Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1

(2013) A. Marijke Keestra et al.   NATURE

A type III effector antagonizes death receptor signalling during bacterial gut infection

(2013) Jaclyn S. Pearson et al.   NATURE

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

(2013) Andrea Ablasser et al.   NATURE

Autophagy Controls an Intrinsic Host Defense to Bacteria by Promoting Epithelial Cell Survival: A Murine Model

(2013) Sun-Young Chang et al.   PLoS One

Intestinal alkaline phosphatase prevents metabolic syndrome in mice

(2013) K. Kaliannan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection

(2013) M. H. Zaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Self-Defense: How Cell-Autonomous Immunity Protects Against Pathogens

(2013) F. Randow et al.   SCIENCE

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

R-Spondin 2 signalling mediates susceptibility to fatal infectious diarrhoea

(2013) Olivier Papapietro et al.   Nature Communications

Salmonella Uses Energy Taxis to Benefit from Intestinal Inflammation

(2013) Fabian Rivera-Chávez et al.   PLoS Pathogens

Salmonella Gut Invasion Involves TTSS-2-Dependent Epithelial Traversal, Basolateral Exit, and Uptake by Epithelium-Sampling Lamina Propria Phagocytes

(2012) Andreas J. Müller et al.   Cell Host & Microbe

Salmonella Transforms Follicle-Associated Epithelial Cells into M Cells to Promote Intestinal Invasion

(2012) Amin Tahoun et al.   Cell Host & Microbe

Innate immune signalling at the intestinal epithelium in homeostasis and disease

(2012) Johanna Pott et al.   EMBO REPORTS

Intestinal Epithelial Toll-Like Receptor 4 Regulates Goblet Cell Development and Is Required for Necrotizing Enterocolitis in Mice

(2012) Chhinder P. Sodhi et al.   GASTROENTEROLOGY

Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium

(2012) Claudia Günther et al.   GUT

CX3CR1+ macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium

(2012) C Manta et al.   Mucosal Immunology

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

Mycobacterium avium subsp. paratuberculosis invades through M cells and enterocytes across ileal and jejunal mucosa of lambs

(2012) Duraisamy Ponnusamy et al.   RESEARCH IN VETERINARY SCIENCE

Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria

(2012) G. F. Sonnenberg et al.   SCIENCE

Human  -Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets

(2012) H. Chu et al.   SCIENCE

The Salmonella Deubiquitinase SseL Inhibits Selective Autophagy of Cytosolic Aggregates

(2012) Francisco S. Mesquita et al.   PLoS Pathogens

The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway

(2011) Marija Cemma et al.   Autophagy

Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

(2011) Jianxin Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

IFN-  determines the intestinal epithelial antiviral host defense

(2011) J. Pott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes

(2011) J. Harper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Antibacterial Lectin RegIII  Promotes the Spatial Segregation of Microbiota and Host in the Intestine

(2011) S. Vaishnava et al.   SCIENCE

Blimp1 regulates the transition of neonatal to adult intestinal epithelium

(2011) Vanesa Muncan et al.   Nature Communications

The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1

(2010) Hanako Morikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metalloprotease type III effectors that specifically cleave JNK and NF-κB

(2010) Kobi Baruch et al.   EMBO JOURNAL

Cell-Cell Propagation of NF-κB Transcription Factor and MAP Kinase Activation Amplifies Innate Immunity against Bacterial Infection

(2010) Christoph Alexander Kasper et al.   IMMUNITY

Listerial invasion protein internalin B promotes entry into ileal Peyer's patches in vivo

(2010) Sayuri Chiba et al.   MICROBIOLOGY AND IMMUNOLOGY

Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)

(2010) D. L. Mallery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reinforcement of epithelial cell adhesion to basement membrane by a bacterial pathogen as a new infectious stratagem

(2010) Minsoo Kim et al.   Virulence

Potentiation of Epithelial Innate Host Responses by Intercellular Communication

(2010) Tamas Dolowschiak et al.   PLoS Pathogens

The Type III Secretion Effector NleE Inhibits NF-κB Activation

(2010) Chen Nadler et al.   PLoS Pathogens

The Enteropathogenic Escherichia coli Effector Cif Induces Delayed Apoptosis in Epithelial Cells

(2009) A. Samba-Louaka et al.   INFECTION AND IMMUNITY

Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response

(2009) Koji Hase et al.   NATURE

Listeria monocytogenes ActA-mediated escape from autophagic recognition

(2009) Yuko Yoshikawa et al.   NATURE CELL BIOLOGY

β-Catenin stabilization imparts crypt progenitor phenotype to hyperproliferating colonic epithelia

(2008) Joseph H. Sellin et al.   EXPERIMENTAL CELL RESEARCH

Secreted enteric antimicrobial activity localises to the mucus surface layer

(2008) U Meyer-Hoffert et al.   GUT

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA