AP-4 loss in CRISPR-edited zebrafish affects early embryo development

AP-4-mediated axonal transport controls endocannabinoid production in neurons

(2022) Alexandra K. Davies et al.   Nature Communications

RUSC2 and WDR47 oppositely regulate kinesin-1–dependent distribution of ATG9A to the cell periphery

(2021) Carlos M. Guardia et al.   MOLECULAR BIOLOGY OF THE CELL

The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A

(2020) Rafael Mattera et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of ap4s1 in zebrafish leads to neurodevelopmental defects resembling spastic paraplegia 52

(2020) Angelica D’Amore et al.   Annals of Clinical and Translational Neurology

Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery

(2020) Carlos M. Guardia et al.   Cell Reports

The role of AP-4 in cargo export from the trans-Golgi network and hereditary spastic paraplegia

(2020) Rafael Mattera et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structure, lipid scrambling activity and role in autophagosome formation of ATG9A

(2020) Shintaro Maeda et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atg8-Family Proteins—Structural Features and Molecular Interactions in Autophagy and Beyond

(2020) Nicole Wesch et al.   Cells

Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome

(2019) Davor Ivankovic et al.   Autophagy

Adaptor protein complexes and disease at a glance

(2019) Anneri Sanger et al.   JOURNAL OF CELL SCIENCE

Adaptor protein complex 4 deficiency: a paradigm of childhood-onset hereditary spastic paraplegia caused by defective protein trafficking

(2019) Robert Behne et al.   HUMAN MOLECULAR GENETICS

Swimming in Deep Water: Zebrafish Modeling of Complicated Forms of Hereditary Spastic Paraplegia and Spastic Ataxia

(2019) Valentina Naef et al.   Frontiers in Neuroscience

Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome

(2018) Raffaella De Pace et al.   PLoS Genetics

A PCR-Based Method for RNA Probes and Applications in Neuroscience

(2018) Ruifang Hua et al.   Frontiers in Neuroscience

AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A

(2018) Alexandra K. Davies et al.   Nature Communications

RICE CRISPR: Rapidly increased cut ends by an exonuclease Cas9 fusion in zebrafish

(2017) Thomas P. Clements et al.   GENESIS

AP-4 mediates export of ATG9A from thetrans-Golgi network to promote autophagosome formation

(2017) Rafael Mattera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and evolution of ENTH and VHS/ENTH-like domains in tepsin

(2017) Tara L. Archuleta et al.   TRAFFIC

Identification of mutations inAP4S1/SPG52 through next generation sequencing in three families

(2016) A. Tessa et al.   EUROPEAN JOURNAL OF NEUROLOGY

Molecular Basis for the Interaction Between AP4 β4 and its Accessory Protein, Tepsin

(2016) Meredith N. Frazier et al.   TRAFFIC

Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex

(2015) Rafael Mattera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recessive loss-of-function mutations in AP4S1 cause mild fever-sensitive seizures, developmental delay and spastic paraplegia through loss of AP-4 complex assembly

(2015) Katia Hardies et al.   HUMAN MOLECULAR GENETICS

A novel AP4M1 mutation in autosomal recessive cerebral palsy syndrome and clinical expansion of AP-4 deficiency

(2014) Muhammad Jameel et al.   BMC Medical Genetics

Helping Hands for Budding Prospects: ENTH/ANTH/VHS Accessory Proteins in Endocytosis, Vacuolar Transport, and Secretion

(2014) Jan Zouhar et al.   PLANT CELL

Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs

(2014) James A. Gagnon et al.   PLoS One

Endocytic Accessory Factors and Regulation of Clathrin-Mediated Endocytosis

(2014) C. J. Merrifield et al.   Cold Spring Harbor Perspectives in Biology

Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles

(2012) Georg H.H. Borner et al.   JOURNAL OF CELL BIOLOGY

Atg9 vesicles are an important membrane source during early steps of autophagosome formation

(2012) Hayashi Yamamoto et al.   JOURNAL OF CELL BIOLOGY

Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy

(2012) A. Orsi et al.   MOLECULAR BIOLOGY OF THE CELL

Mutation in the AP4B1 gene cause hereditary spastic paraplegia type 47 (SPG47)

(2012) Peter Bauer et al.   NEUROGENETICS

Adaptor Protein Complexes AP-4 and AP-5: New Players in Endosomal Trafficking and Progressive Spastic Paraplegia

(2012) Jennifer Hirst et al.   TRAFFIC

Adaptor Protein Complex 4 Deficiency Causes Severe Autosomal-Recessive Intellectual Disability, Progressive Spastic Paraplegia, Shy Character, and Short Stature

(2011) Rami Abou Jamra et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex

(2010) Patricia V. Burgos et al.   DEVELOPMENTAL CELL

Sec24D-Dependent Transport of Extracellular Matrix Proteins Is Required for Zebrafish Skeletal Morphogenesis

(2010) Swapnalee Sarmah et al.   PLoS One

Structural Requirements for PACSIN/Syndapin Operation during Zebrafish Embryonic Notochord Development

(2009) Melissa A. Edeling et al.   PLoS One

Characterization of housekeeping genes in zebrafish: male-female differences and effects of tissue type, developmental stage and chemical treatment

(2008) Amy T McCurley et al.   BMC MOLECULAR BIOLOGY

Atg8 Controls Phagophore Expansion during Autophagosome Formation

(2008) Zhiping Xie et al.   MOLECULAR BIOLOGY OF THE CELL

Accumulation of AMPA Receptors in Autophagosomes in Neuronal Axons Lacking Adaptor Protein AP-4

(2008) Shinji Matsuda et al.   NEURON