Review
Medicine, General & Internal
Lou'i Al-Husinat, Alameen Alsabbah, Amer Abu Hmaid, Razan Athamneh, Majd Adwan, Mohammad N. N. Hourani, Seif Almakhadmeh, Zaid Jehad Al Modanat, Mohammed I. A. Ismail, Giustino Varrassi
Summary: Sepsis, a severe complication of infection, can lead to life-threatening inflammatory responses. Septic shock, a complication of sepsis, occurs when hemodynamic instability arises. The pathophysiology and hemodynamic mechanisms of acute kidney injury in sepsis or septic shock are not fully understood, but multiple possible mechanisms have been suggested. Norepinephrine is commonly used in septic shock management, but its effects on renal circulation and potential exacerbation of acute kidney injury are still debated. This narrative review provides updates, explanations, and evidence on sepsis and septic shock, aiming to improve clinical understanding of the adverse outcomes of norepinephrine use in sepsis-associated acute kidney injury.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Ari Moskowitz, Katherine M. Berg, Anne V. Grossestreuer, Lakshman Balaji, Xiaowen Liu, Michael N. Cocchi, Maureen Chase, Michelle Ng Gong, Jonathan Gong, Samir M. Parikh, Long Ngo, Noa Berlin, Michael W. Donnino
Summary: Thiamine supplementation does not significantly attenuate kidney injury in patients with septic shock, but it does increase ICU-free days.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Oncology
June-Sung Kim, Ye-Jee Kim, Youn-Jung Kim, Won Young Kim
Summary: This study aimed to determine whether dialysis-requiring acute kidney injury in cancer patients could be related to an increase in short-term and long-term negative outcomes. The study found that dialysis-requiring septic acute kidney injury was associated with male sex, hematologic cancers, and comorbidities. It was also significantly associated with increased long-term mortality in cancer patients, suggesting the importance of prevention, especially in male hematologic cancer patients.
Article
Critical Care Medicine
Haibing Sun, Huiping Jiang, Amity Eliaz, John A. Kellum, Zhiyong Peng, Isaac Eliaz
Summary: Gal-3 plays a crucial role in the pathogenesis of S-AKI and its inhibitor P-MCP shows potential as a therapeutic target, significantly reducing mortality and incidence of severe sepsis-associated AKI.
Review
Emergency Medicine
Bo Wang, Jun Xu, Ping Fu, Liang Ma
Summary: Sepsis-induced acute kidney injury (AKI) is a potentially fatal complication of burns and trauma, but its mechanisms are poorly understood. Despite medical advances, effective therapeutic regimens for septic AKI are uncommon. Recent evidence has shown that miRNAs are closely associated with septic AKI, and this review aims to summarize the functional role of miRNAs in septic AKI and explore their potential as biomarkers and therapeutic targets.
Article
Chemistry, Medicinal
Heng Fan, Bin-jie Su, Jian-wei Le, Jian-hua Zhu
Summary: Pretreatment with SLDS can protect the kidneys of septic rats by inhibiting inflammation and apoptosis of kidney tubular epithelial cells.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Critical Care Medicine
Natalja L. Stanski, Rajit K. Basu, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Neal J. Thomas, Torrey Baines, Bereketeab Haileselassie, Scott L. Weiss, Mihir R. Atreya, Andrew J. Lautz, Basilia Zingarelli, Stephen W. Standage, Jennifer Kaplan, Lakhmir S. Chawla, Stuart L. Goldstein
Summary: Prediction of severe acute kidney injury (AKI) is crucial for improving outcomes and treatment in pediatric septic shock. In this study, we evaluated the performance of the modified renal angina index (sRAI) in a separate cohort and found that it had better accuracy and specificity compared to the original RAI and serum creatinine elevation.
Article
Critical Care Medicine
Mihir R. Atreya, Natalie Z. Cvijanovich, Julie C. Fitzgerald, Scott L. Weiss, Michael T. Bigham, Parag N. Jain, Adam J. Schwarz, Riad Lutfi, Jeffrey Nowak, Geoffrey L. Allen, Neal J. Thomas, Jocelyn R. Grunwell, Torrey Baines, Michael Quasney, Bereketeab Haileselassie, Matthew N. Alder, Stuart L. Goldstein, Natalja L. Stanski
Summary: Endothelial dysfunction biomarkers are independently associated with the risk of severe sepsis-associated acute kidney injury (SA-AKI) in children. These biomarkers may facilitate the selection of therapeutics and predict treatment outcomes.
Article
Immunology
Jiefu Zhu, Yafei Zhang, Lang Shi, Yao Xia, Hongchu Zha, Huimin Li, Zhixia Song
Summary: This study reveals the protective role of RP105 in ischemic and septic acute kidney injury (AKI). Overexpression of RP105 alleviated renal structural injuries and dysfunction caused by ischemic and septic AKI. RP105 suppressed inflammatory responses mediated by the TLR4 signaling pathway. These findings suggest that RP105 could be a potential target for preventing and treating ischemic and septic AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Critical Care Medicine
Julie Helms, Hamid Merdji, Sebastien Loewert, Francois Severac, Alexandra Monnier, Julian Kaurin, Anais Curtiaud, Ferhat Meziani, Julien Demiselle
Summary: This study analyzed the association between the occurrence, severity, and evolution of AKI in patients with septic shock-induced DIC. The results showed that DIC is strongly associated with the risk of developing the more severe form of AKI (stage 3 of the KDIGO classification, RRT requirement), even after adjusting for other factors.
ANNALS OF INTENSIVE CARE
(2023)
Article
Medicine, General & Internal
Tomasz Skalec, Barbara Adamik, Katarzyna Kobylinska, Waldemar Gozdzik
Summary: The study aimed to establish the optimal suPAR cut-off point for predicting KRT use in sepsis patients and to analyze survival rates based on suPAR levels, AKI diagnosis, and the requirement for KRT. The results indicate that suPAR measurements may have important implications in the diagnosis of sepsis patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Jamie R. Privratsky, Shintaro Ide, Yanting Chen, Hiroki Kitai, Jiafa Ren, Helene Fradin, Xiaohan Lu, Tomokazu Souma, Steven D. Crowley
Summary: Regulatory systems can stimulate financial innovation. Banks with lighter regulatory pressure are more inclined to launch new financial products and are also more willing to face financial risks.
KIDNEY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Ying Wang, Jiefu Zhu, Zhiwen Liu, Shaoqun Shu, Ying Fu, Yuxue Liu, Juan Cai, Chengyuan Tang, Yu Liu, Xiaoming Yin, Zheng Dong
Summary: The study demonstrated the induction of mitophagy in septic AKI models and revealed the role of the PINK1/PARK2 pathway. Mitophagy during sepsis plays a beneficial role in tubular cell survival and renal function.
Article
Immunology
Si Chen, Hua Gan
Summary: This study identified and validated four biomarkers associated with abnormal glycosylation that could be potential targets for AKI in sepsis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Medicine, General & Internal
Mingjing Guan, Hao Wang, Xin Tang, Yuliang Zhao, Fang Wang, Ling Zhang, Ping Fu
Summary: This study aimed to compare the efficacy of adsorbing filter oXiris in the treatment of sepsis/septic shock-associated acute kidney injury (S-AKI). The results showed that the oXiris group had lower early mortality, faster reduction of inflammatory mediators, and played a favorably important role in the prognosis compared to the control group.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Bing Xie, Jiancheng Zhang, Yuwen Li, Shiying Yuan, You Shang
Summary: COVID-19, caused by SARS-CoV-2, has led to high morbidity and mortality globally. While most infected individuals are asymptomatic or have mild symptoms, immunocompromised patients are at risk of progressing to severe cases. A well-coordinated immune response and understanding of the immunological processes underlying COVID-19 are crucial for effective treatment and management.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Critical Care Medicine
Xuehui Gao, Wen Yang, Huaqing Shu, Xiaobo Yang, Yuan Yu, You Shang
Editorial Material
Medicine, General & Internal
Yue-Tian Yu, Jiao Liu, Bo Hu, Rui-Lan Wang, Xiang-Hong Yang, Xiu-Ling Shang, Gang Wang, Chang-Song Wang, Bai-Ling Li, Ye Gong, Sheng Zhang, Xin Li, Lu Wang, Min Shao, Mei Meng, Feng Zhu, You Shang, Qiang-Hong Xu, Zhi-Xiong Wu, De-Chang Chen
CHINESE MEDICAL JOURNAL
(2021)
Article
Critical Care Medicine
Yaxin Wang, Xiangzhi Fang, Yiyi Yang, Lin Chen, Wei Xiong, Limin Song, Bo Li, Ting Zhou, Yuan Yu, Xiaobo Yang, Huaqing Shu, Shiying Yuan, Shanglong Yao, You Shang
Summary: In this study, it was found that DAPK1 mediated cyclic stretch-induced alveolar epithelial cell apoptosis and ventilator-induced lung injury through the P53 pathway. Inhibition of DAPK1 or P53 can alleviate high tidal volume ventilation-induced lung injury and alveolar epithelial cell apoptosis.
Article
Cell Biology
Ruiting Li, Xuemei Hu, Huibin Chen, Yue Zhao, Xuehui Gao, Yin Yuan, Huiling Guo, Haiyan Huang, Xiaojing Zou, Hong Qi, Hong Liu, You Shang
Summary: This study suggests that the cholinergic anti-inflammatory pathway contributes to the reduction in the inflammatory response in ALI by regulating the maturation, phenotype, and quantity of DCs and conventional DCs.
MEDIATORS OF INFLAMMATION
(2022)
Review
Respiratory System
Xuehui Gao, Xiaojing Zou, Ruiting Li, Huaqing Shu, Yuan Yu, Xiaobo Yang, You Shang
Summary: COVID-19 has been a global challenge for more than two years. The recent emergence of mutant virus strains has posed even greater obstacles to disease prevention and treatment. Point-of-care ultrasound (POCUS) is recommended for regular use in COVID-19 patients, particularly in respiratory failure management. This review summarizes the ultrasound characteristics of COVID-19 patients, focusing on lung ultrasound and echocardiography, and discusses the experience of using POCUS to manage COVID-19-related acute respiratory distress syndrome (ARDS).
BMC PULMONARY MEDICINE
(2022)
Review
Medicine, General & Internal
Hongling Zhang, Jiqian Xu, Xiaobo Yang, Xiaojing Zou, Huaqing Shu, Zhengdong Liu, You Shang
Summary: ECMO is a life-saving technique used worldwide, especially during the COVID-19 pandemic, but patients undergoing ECMO have a low survival rate due to various complications. The neurological morbidity associated with ECMO has been increasingly focused on, with early recognition of neurologic injury being crucial for patient outcomes. Multimodal monitoring is advocated as an important approach for early diagnosis of devastating neurologic injuries in ECMO patients.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Shangwen Pan, Huaqing Shu, Yaxin Wang, Ruiting Li, Ting Zhou, Yuan Yu, Jiqian Xu, Wei Xiong, Xiaobo Yang, Jiancheng Zhang, Yin Yuan, Shiying Yuan, You Shang
Summary: By analyzing data from 118 confirmed SARS-CoV-2 patients, it was found that characteristics such as lymphocyte and platelet levels, as well as lesion areas on CT scans, were associated with disease severity. The study suggests that combining clinical features with specific CT levels can effectively predict severe/critical cases of SARS-CoV-2 pneumonia.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Jiqian Xu, Xiaobo Yang, Zheng Lv, Ting Zhou, Hong Liu, Xiaojing Zou, Fengsheng Cao, Lu Zhang, Boyi Liu, Wei Chen, Yuan Yu, Huaqing Shu, Shiying Yuan, Ming Hu, Chaolin Huang, You Shang
Summary: This study found that thrombocytopenia, vasopressor use, and corticosteroid treatment were significantly associated with an increased risk of incident IPA in COVID-19 patients admitted to ICUs. The occurrence of CAPA may lead to longer ICU stays and higher 180-day mortality compared to those without CAPA.
FRONTIERS IN MEDICINE
(2021)
Editorial Material
Emergency Medicine
Rui-ting Li, Yue Zhao, Xiao-jing Zou, Hua-qing Shu, Ting Zhou, Shang-wen Pan, Xue-hui Gao, Hai-yan Huang, Hong Liu, You Shang
WORLD JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Hong Qi, Jiancheng Zhang, You Shang, Shiying Yuan, Chunqing Meng
Summary: Argon preconditioning can inhibit the PDCD4/PTEN pathway through miR-21, reducing oxidative stress and inflammatory factor levels, protecting cardiomyocytes from MI/R injury.
Article
Biochemistry & Molecular Biology
Yufen Zhang, Sehui Ma, Xiao Ke, Yao Yi, Hongyan Yu, Dian Yu, Qiang Li, You Shang, Youming Lu, Lei Pei
Summary: The study reveals that Annexin A1 (ANXA1) exerts analgesic effects at the dorsal root ganglia (DRG) level through targeting TRPV1 and can desensitize TRPV1 via activation of the FPR2 receptor by specific peptide, potentially providing a target for developing novel analgesic drugs.
CELL AND BIOSCIENCE
(2021)
Article
Obstetrics & Gynecology
Yin Zhao, Bangxing Huang, Hui Ma, You Shang, Xiu Nie, Li Zou
Summary: This study analyzed the clinical data of 5 pregnant women who were infected with COVID-19 in early pregnancy, showing that infants were healthy and asymptomatic at 3-6 months after birth, with no adverse outcomes observed. Placental pathology revealed chronic ischemia changes, suggesting that COVID-19 may cause placental injury.
MATERNAL-FETAL MEDICINE
(2021)
Article
Immunology
Jingyi Yang, Maohua Zhong, Ke Hong, Qingyu Yang, Ejuan Zhang, Dihan Zhou, Jianbo Xia, Yao-Qing Chen, Mingbo Sun, Bali Zhao, Jie Xiang, Ying Liu, Yang Han, Mengxin Xu, Xi Zhou, Chaolin Huang, You Shang, Huimin Yan
Summary: Prolonged SARS-CoV-2 positivity (PP) is associated with suppressed CD8(+) T-cell differentiation, which may serve as an indicator for predicting prolonged positivity in COVID-19 patients. Additionally, PP cohort showed a weaker SARS-CoV-2 N protein-specific IFN-gamma(+) T-cell response and a higher frequency of Tregs.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)