Fibronectin Mechanobiology Regulates Tumorigenesis

Stiffening and unfolding of early deposited-fibronectin increase proangiogenic factor secretion by breast cancer-associated stromal cells

(2015) Karin Wang et al.   BIOMATERIALS

EDA Fibronectin in Keloids Create a Vicious Cycle of Fibrotic Tumor Formation

(2015) Rhiannon M. Kelsh et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The α4β1 integrin and the EDA domain of fibronectin regulate a profibrotic phenotype in dermal fibroblasts

(2015) Arti V. Shinde et al.   MATRIX BIOLOGY

Tissue stiffness regulates serine/arginine-rich protein-mediated splicing of the extra domain B-fibronectin isoform in tumors

(2015) Francois Bordeleau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer

(2015) Ruchi Malik et al.   TRENDS IN BIOTECHNOLOGY

Molecular architecture of native fibronectin fibrils

(2015) Susanna Maria Früh et al.   Nature Communications

Therapeutic vaccination against fibronectin ED-A attenuates progression of metastatic breast cancer

(2015) Julia Femel et al.   Oncotarget

Extracellular acidity, a “reappreciated” trait of tumor environment driving malignancy: perspectives in diagnosis and therapy

(2014) Silvia Peppicelli et al.   CANCER AND METASTASIS REVIEWS

Endothelial cell-derived fibronectin extra domain A promotes colorectal cancer metastasis via inducing epithelial–mesenchymal transition

(2014) Juanjuan Ou et al.   CARCINOGENESIS

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Opposing effects of collagen I and vitronectin on fibronectin fibril structure and function

(2014) Candace D. Gildner et al.   MATRIX BIOLOGY

Rigidity sensing and adaptation through regulation of integrin types

(2014) Alberto Elosegui-Artola et al.   NATURE MATERIALS

Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area

(2014) Stephanie Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiscale relationships between fibronectin structure and functional properties

(2013) M.J. Bradshaw et al.   Acta Biomaterialia

Regulation of Matrix Assembly through Rigidity-dependent Fibronectin Conformational Changes

(2013) Cara L. Carraher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Analysis of Collagen Type I Interactions with Human Fibronectin Reveals a Cooperative Binding Mode

(2013) Michèle C. Erat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparin-dependent regulation of fibronectin matrix conformation

(2013) Brant Hubbard et al.   MATRIX BIOLOGY

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Regional Fibronectin and Collagen Fibril Co-Assembly Directs Cell Proliferation and Microtissue Morphology

(2013) Carlos A. Sevilla et al.   PLoS One

Electrical Control of Protein Conformation

(2012) Alwin M. D. Wan et al.   ADVANCED MATERIALS

Fibronectin matrix-mediated cohesion suppresses invasion of prostate cancer cells

(2012) Dongxuan Jia et al.   BMC CANCER

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition

(2012) Jennifer L. Leight et al.   MOLECULAR BIOLOGY OF THE CELL

The Extra Domain A of Fibronectin Increases VEGF-C Expression in Colorectal Carcinoma Involving the PI3K/AKT Signaling Pathway

(2012) Lisha Xiang et al.   PLoS One

Matrix metalloproteinase-2 Promotes αvβ3 Integrin-Mediated Adhesion and Migration of Human Melanoma Cells by Cleaving Fibronectin

(2012) Yang Jiao et al.   PLoS One

Phage-based molecular probes that discriminate force-induced structural states of fibronectin in vivo

(2012) L. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The First Type III Domain of Fibronectin is Associated with the Expression of Cytokines within the Lung Tumor Microenvironment

(2012) Mingzhe Zheng et al.   Journal of Cancer

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

A Fibronectin-Independent Mechanism of Collagen Fibrillogenesis in Adult Liver Remodeling

(2011) Kei Moriya et al.   GASTROENTEROLOGY

Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells

(2011) M. A. Antonyak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical stretch and shear flow induced reorganization and recruitment of fibronectin in fibroblasts

(2011) Robert L. Steward et al.   Scientific Reports

Assembly of Fibronectin Extracellular Matrix

(2010) Purva Singh et al.   Annual Review of Cell and Developmental Biology

N-terminal and C-terminal heparin-binding domain polypeptides derived from fibronectin reduce adhesion and invasion of liver cancer cells

(2010) Nan-Hong Tang et al.   BMC CANCER

Vaccination against the extra domain-B of fibronectin as a novel tumor therapy

(2010) Elisabeth J. M. Huijbers et al.   FASEB JOURNAL

The 12th–14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain

(2010) Mikaël M. Martino et al.   FASEB JOURNAL

Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells

(2010) Tom T. Chen et al.   JOURNAL OF CELL BIOLOGY

Alternative Splicing of the Angiogenesis Associated Extra-Domain B of Fibronectin Regulates the Accessibility of the B-C Loop of the Type III Repeat 8

(2010) Elisa Ventura et al.   PLoS One

Autocrine TGF-  and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

(2010) Y. Kojima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression

(2010) P. Schedin et al.   Cold Spring Harbor Perspectives in Biology

The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF

(2009) Sean M. Anderson et al.   BIOMATERIALS

Cell Traction Forces Direct Fibronectin Matrix Assembly

(2009) Christopher A. Lemmon et al.   BIOPHYSICAL JOURNAL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Crosslinking of cell-derived 3D scaffolds up-regulates the stretching and unfolding of new extracellular matrix assembled by reseeded cells

(2009) Kristopher E. Kubow et al.   Integrative Biology

A novel human fibronectin cryptic sequence unmasked by the insertion of the angiogenesis-associated extra type III domain B

(2009) Enrica Balza et al.   INTERNATIONAL JOURNAL OF CANCER

Identification and structural analysis of type I collagen sites in complex with fibronectin fragments

(2009) M. C. Erat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibronectin forms the most extensible biological fibers displaying switchable force-exposed cryptic binding sites

(2009) E. Klotzsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clustering of  5 1 integrins determines adhesion strength whereas  v 3 and talin enable mechanotransduction

(2009) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

TGFβ in Cancer

(2008) Joan Massagué   CELL

Fibronectin in aging extracellular matrix fibrils is progressively unfolded by cells and elicits an enhanced rigidity response

(2008) Meher Antia et al.   FARADAY DISCUSSIONS

Extracellular Matrix Fibronectin Mechanically Couples Skeletal Muscle Contraction With Local Vasodilation

(2007) Denise C. Hocking et al.   CIRCULATION RESEARCH