Article
Biology
Matteo Salvador, Francesco Regazzoni, Stefano Pagani, Luca Dede', Natalia Trayanova, Alfio Quarteroni
Summary: This paper investigates the effects of mechano-electric feedbacks (MEFs) on myocardial deformation and nonselective stretch-activated channels (SACs). Numerical simulations show that all MEFs can alter the propagation of transmembrane potential. Introduction of myocardial deformation changes the basic cycle length and conduction velocity of ventricular tachycardia (VT), while nonselective SACs may turn a stable VT into an unstable one.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Marta Varela, Aditi Roy, Jack Lee
Summary: This review explores the mechano-electric coupling (MEC) in atrial tissue, discussing different mechanisms related to chronic atrial dilation and atrial fibrillation. Computational simulations are used to assess the impact of each pathway on action potential duration, conduction velocity, and rotor stability. Findings suggest that physiological atrial stretches, such as passive stretch during the atrial reservoir phase, may contribute significantly to the mechanisms of atrial arrhythmogenesis.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2021)
Article
Biology
Weijia Sun, Yuheng Li, Jianwei Li, Yingjun Tan, Xinxin Yuan, Haoye Meng, Jianting Ye, Guohui Zhong, XiaoYan Jin, Zizhong Liu, Ruikai Du, Wenjuan Xing, Dingsheng Zhao, Jinping Song, Youyou Li, Junjie Pan, Yunzhang Zhao, Qi Li, Aiyuan Wang, Shukuan Ling, Rongji Dai, Yingxian Li
Summary: Mechanical force loading is crucial for maintaining bone homeostasis, and Ano1 mediates osteoclast responses to mechanical stimulation, playing an important role in mechanical stimulation-induced osteoclast activity changes.
COMMUNICATIONS BIOLOGY
(2023)
Review
Physiology
T. Alexander Quinn, Peter Kohl
Summary: The heart is crucial for biological function and its continuous beating requires precise coordination of billions of cells. Mechano-electric coupling plays a key role in regulating cardiac function, providing acute beat-by-beat feedback from the local mechanical environment to electrical activity. This process is essential for understanding both healthy and diseased states of the heart.
PHYSIOLOGICAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Flavia Ravelli, Michela Mase
Summary: Atrial fibrillation is a multifactorial disease that often occurs in the presence of underlying cardiac abnormalities and is supported by electrophysiological and structural alterations. MicroRNAs are emerging as potential regulators in the pathogenesis of AF, particularly in modulating atrial electrical and structural remodeling. Abnormal substrates in various conditions such as hypertension, heart failure, obesity, and sleep apnea contribute to the predisposition to AF.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2021)
Article
Biology
Nicholas F. Pearce, Mark C. Turner, Helen L. Maddock, Eun-jin Kim
Summary: Numerical models of the cardiovascular system have mainly focused on the ventricles and neglected the function of the atrium. The commonly used time-varying elastance method for the ventricles and atrium has yet to be validated, raising questions about its applicability. To address this, we propose a model that integrates feedback mechanisms among various functions and components of the cardiovascular system. The model successfully reproduces atrium cycling and investigates the effects of mechanical-electric feedback dysfunction in the atrium.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Computer Science, Interdisciplinary Applications
Yongjae Lee, Baris Cansiz, Michael Kaliske
Summary: This study investigates the role of mechano-electric feedback (MEF) in healthy cardiac cycles and in cardiac arrhythmia using human ventricular models. The effect of different models for stretch-activated channels (SACs) and material properties on the heart model is analyzed, and the importance of MEF in fibrillation and defibrillation is demonstrated.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2022)
Article
Biotechnology & Applied Microbiology
Nicholas Pearce, Eun-jin Kim
Summary: Cardiac diseases and failure are major contributors to global mortality and significantly impact the quality of life for millions of people. This study investigates the effects of valve disorders on the mechano-electric feedback (MEF) and arrhythmia using a synergistic low-order numerical model. The findings reveal that valve stenosis and regurgitation increase the sensitivity to arrhythmia, and regurgitation accompanied by diastolic stretch leads to more severe arrhythmia.
BIOENGINEERING-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Dapeng Ren, Ran Liu, Xiao Yan, Qiang Zhang, Xuemin Zeng, Xiao Yuan
Summary: In this study, the role of calreticulin (CRT) and plasma membrane Ca2+ transporting ATPase 1 (PMCA1) in stretch-induced apoptosis of myoblasts was investigated. The results showed that stretching stimuli increased CRT level while inhibiting PMCA1 activity, and there were bidirectional regulations between CRT and PMCA1. These two proteins formed a positive feedback loop, contributing to intracellular Ca2+ accumulation and myoblast apoptosis.
Article
Nanoscience & Nanotechnology
Harish Devaraj, Qi Tian, Weihong Guo, Rajiv Malhotra
Summary: Thermally driven sintering is widely used for enhancing the conductivity of metal nanowire ensembles in printed electronics, with a new modeling framework successfully linking atomistic simulations of neck growth to ensemble conductivity evolution. The experimental validation demonstrates ultra-low computational effort and rapid design capability.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biology
Abbish Kamalakkannan, Peter R. Johnston, Barbara M. Johnston
Summary: Accurate values for cardiac bidomain conductivities are crucial for computational studies, and a protocol presented in this paper demonstrates a more accurate retrieval method using an additive Gaussian noise model. Comparison of prefabricated electrode arrays showed that a rectangular 128-electrode array was more capable of retrieving cardiac conductivities than other tested arrays, suggesting its use in experimental trials.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Engineering, Mechanical
Xingzhen Huang, Zhaoxia Li
Summary: The fatigue reliability of film interconnects in flexible electronics is crucial for device stability. This study proposes a multi-scale damage model and a multi-scale mechano-electric degradation model to evaluate the reliability and predict damage of film interconnects.
FATIGUE & FRACTURE OF ENGINEERING MATERIALS & STRUCTURES
(2023)
Article
Multidisciplinary Sciences
Fyodor Syomin, Anna Osepyan, Andrey Tsaturyan
Summary: The model of myocardial electromechanics integrates multiple aspects of cardiac physiology to simulate the response of the myocardium under different conditions. By reducing the stiffness of the differential equations, the model can be numerically integrated with a relatively high time step, making it suitable for multiscale simulation of the human heart and allowing the study of the impact of myocardial mechanics on arrhythmias.
Article
Mathematical & Computational Biology
Heqing Zhan, Zefeng Wang, Jialun Lin, Yuanbo Yu, Ling Xia
Summary: This study investigated the effects of optogenetic stimulation on the characteristics of excitation-contraction coupling (ECC) and mechano-electric feedback (MEF) in cardiomyocytes. It was found that increased light duration prolonged action potential duration (APD) and muscle twitch, with inward ChR2 current playing a significant role in these processes. The findings suggest that optogenetic actuation should be considered in future cardiac computational optogenetics at the tissue and organ scale.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2021)
Article
Materials Science, Multidisciplinary
Ruizhi Wang, Enling Tang, Guolai Yang, Quanzhao Sun, Yafei Han, Chuang Chen
Summary: The mechanical and electrical responses of PZT-5H under different strain rates were investigated, and a mechano-electric model considering the strain rate effects was built based on experimental data. The model was verified with finite element simulation results and adopted to predict the performance of piezoelectric ceramics in overload igniter applications.
MECHANICS OF MATERIALS
(2021)
Article
Toxicology
Hua Rong Lu, Ross Whittaker, Jeffrey H. Price, Raquel Vega, Emily R. Pfeiffer, Fabio Cerignoli, Rob Towart, David J. Gallacher
TOXICOLOGICAL SCIENCES
(2015)
Meeting Abstract
Pharmacology & Pharmacy
Raquel Vega, Emily Pfeiffer, Ross Whittaker
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2015)
Article
Pharmacology & Pharmacy
Emily R. Pfeiffer, Raquel Vega, Patrick M. McDonough, Jeffrey H. Price, Ross Whittaker
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2016)
Article
Biophysics
Barney K. Tam, Jennifer H. Shin, Emily Pfeiffer, P. Matsudaira, L. Mahadevan
BIOPHYSICAL JOURNAL
(2009)
Meeting Abstract
Biophysics
Emily Pfeiffer, Barbara Murienne, Jennifer Stowe, Katie McNall, Adam Wright, Andrew McCulloch
BIOPHYSICAL JOURNAL
(2012)
Article
Biochemistry & Molecular Biology
Robert C. Lyon, Valeria Mezzano, Adam T. Wright, Emily Pfeiffer, Joyce Chuang, Katherine Banares, Allan Castaneda, Kunfu Ouyang, Li Cui, Riccardo Contu, Yusu Gu, Sylvia M. Evans, Jeffrey H. Omens, Kirk L. Peterson, Andrew D. McCulloch, Farah Sheikh
HUMAN MOLECULAR GENETICS
(2014)
Article
Biophysics
Emily R. Pfeiffer, Jared R. Tangney, Jeffrey H. Omens, Andrew D. McCulloch
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2014)
Article
Cardiac & Cardiovascular Systems
E. R. Pfeiffer, A. T. Wright, A. G. Edwards, J. C. Stowe, K. McNall, J. Tan, I. Niesman, H. H. Patel, D. M. Roth, J. H. Omens, A. D. McCulloch
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2014)
Article
Cell Biology
Joshua T. Morgan, Emily R. Pfeiffer, Twanda L. Thirkill, Priyadarsini Kumar, Gordon Peng, Heidi N. Fridolfsson, Gordon C. Douglas, Daniel A. Starr, Abdul I. Barakat
MOLECULAR BIOLOGY OF THE CELL
(2011)
Article
Orthopedics
E. Pfeiffer, S. M. Vickers, E. Frank, A. J. Grodzinsky, M. Spector
OSTEOARTHRITIS AND CARTILAGE
(2008)
Article
Genetics & Heredity
Indroneal Banerjee, Jianlin Zhang, Thomas Moore-Morris, Emily Pfeiffer, Kyle S. Buchholz, Ao Liu, Kunfu Ouyang, Matthew J. Stroud, Larry Gerace, Sylvia M. Evans, Andrew McCulloch, Ju Chen