Neuropathology-Independent Association BetweenAPOEGenotype and Cognitive Decline Rate in the Normal Aging-Early Alzheimer Continuum

Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum

(2022) Willemijn J. Jansen et al.   JAMA Neurology

APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer’s disease with Lewy body pathology

(2022) Yunjung Jin et al.   ACTA NEUROPATHOLOGICA

A multi‐hit hypothesis for an APOE4 ‐dependent pathophysiological state

(2022) O. G. Steele et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study

(2021) Amin Gharbi-Meliani et al.   Alzheimers Research & Therapy

To what degree is late life cognitive decline driven by age-related neuropathologies?

(2021) Patricia A Boyle et al.   BRAIN

Association of APOE Genotype With Heterogeneity of Cognitive Decline Rate in Alzheimer Disease

(2021) Jing Qian et al.   NEUROLOGY

Diversity of transcriptomic microglial phenotypes in aging and Alzheimer's disease

(2021) Delphine Boche et al.   Alzheimers & Dementia

Segmented Linear Mixed Model Analysis Reveals Association of the APOE ɛ4 Allele with Faster Rate of Alzheimer’s Disease Dementia Progression

(2021) X. Richard Chen et al.   JOURNAL OF ALZHEIMERS DISEASE

APOE E2/E2 Is Associated with Slower Rate of Cognitive Decline with Age

(2021) Benjamin Sweigart et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammatory Pathways Are Impaired in Alzheimer Disease and Differentially Associated With Apolipoprotein E Status

(2021) Courtney M Kloske et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Finding Treatment Effects in Alzheimer Trials in the Face of Disease Progression Heterogeneity

(2021) Roos J. Jutten et al.   NEUROLOGY

APOE4 derived from astrocytes leads to blood–brain barrier impairment

(2021) Rosemary J. Jackson et al.   BRAIN

The probabilistic model of Alzheimer disease: the amyloid hypothesis revised

(2021) Giovanni B. Frisoni et al.   NATURE REVIEWS NEUROSCIENCE

The multiplex model of the genetics of Alzheimer’s disease

(2020) Rebecca Sims et al.   NATURE NEUROSCIENCE

APOE genotype regulates pathology and disease progression in synucleinopathy

(2020) Albert A. Davis et al.   Science Translational Medicine

Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

(2020) Eric M. Reiman et al.   Nature Communications

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes

(2020) Adam S. Fleisher et al.   JAMA Neurology

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches

(2020) Alberto Serrano-Pozo et al.   LANCET NEUROLOGY

Is Alzheimer’s Disease Risk Modifiable?

(2019) Alberto Serrano-Pozo et al.   JOURNAL OF ALZHEIMERS DISEASE

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report

(2019) Peter T Nelson et al.   BRAIN

Impaired memory-guided attention in asymptomatic APOE4 carriers

(2019) Jacqueline Zimmermann et al.   Scientific Reports

APOE is a correlate of phenotypic heterogeneity in Alzheimer disease in a national cohort

(2019) Sandra Weintraub et al.   NEUROLOGY

Version 3 of the Alzheimer Disease Centers’ Neuropsychological Test Battery in the Uniform Data Set (UDS)

(2018) Sandra Weintraub et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

The Revised National Alzheimer’s Coordinating Center’s Neuropathology Form—Available Data and New Analyses

(2018) Lilah M Besser et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Resistance vs resilience to Alzheimer disease

(2018) Eider M. Arenaza-Urquijo et al.   NEUROLOGY

Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study

(2018) Hyun-Sik Yang et al.   LANCET NEUROLOGY

APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology

(2018) Dennis W. Dickson et al.   NEUROLOGY

APOE genotypes as a risk factor for age-dependent accumulation of cerebrovascular disease in older adults

(2018) Melissa Lamar et al.   Alzheimers & Dementia

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative

(2018) Dallas P. Veitch et al.   Alzheimers & Dementia

Association of Apolipoprotein E ε4 With Transactive Response DNA-Binding Protein 43

(2018) Alexandra M. Wennberg et al.   JAMA Neurology

The Elusive Nature of APOE ε4 in Mid-adulthood: Understanding the Cognitive Profile

(2017) Claire Lancaster et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease

(2016) Jonathan M. Schott et al.   Alzheimers & Dementia

Post Hoc Analyses of ApoE Genotype-Defined Subgroups in Clinical Trials

(2016) Richard E. Kennedy et al.   JOURNAL OF ALZHEIMERS DISEASE

Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum

(2016) Alberto Serrano-Pozo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The APOE paradox: do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline

(2016) Claire Lancaster et al.   NEUROBIOLOGY OF AGING

APOEε2 is associated with milder clinical and pathological Alzheimer disease

(2015) Alberto Serrano-Pozo et al.   ANNALS OF NEUROLOGY

Cognitive and neural signatures of the APOE E4 allele in mid-aged adults

(2014) Simon Evans et al.   NEUROBIOLOGY OF AGING

Effect of APOE genotype status on targeted clinical trials outcomes and efficiency in dementia and mild cognitive impairment resulting from Alzheimer's disease

(2013) Richard E. Kennedy et al.   Alzheimers & Dementia

Examination of the Clinicopathologic Continuum of Alzheimer Disease in the Autopsy Cohort of the National Alzheimer Coordinating Center

(2013) Alberto Serrano-Pozo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Dysexecutive Versus Amnestic Alzheimer Disease Subgroups

(2012) Jesse Mez et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Joint latent class models for longitudinal and time-to-event data: A review

(2012) Cécile Proust-Lima et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristics

(2010) B. C. Dickerson et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease

(2010) D. A. Wolk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Alzheimerʼs Disease Centersʼ Uniform Data Set (UDS)

(2009) Sandra Weintraub et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS