Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging

PARP inhibition impedes the maturation of nascent DNA strands during DNA replication

(2022) Alina Vaitsiankova et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibitors of PARP: Number crunching and structure gazing

(2022) Johannes Rudolph et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells

(2021) Priyanka Verma et al.   NATURE CELL BIOLOGY

Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs

(2021) Johannes Rudolph et al.   Nature Communications

Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy

(2021) Miles K. Huseyin et al.   Nature Communications

XRCC1 prevents toxic PARP1 trapping during DNA base excision repair

(2021) Annie A. Demin et al.   MOLECULAR CELL

A glitch in the snitch: the role of linker histone H1 in shaping the epigenome in normal and diseased cells

(2021) Ankita Saha et al.   Open Biology

Single-molecule measurements reveal that PARP1 condenses DNA by loop stabilization

(2021) Nicholas A. W. Bell et al.   Science Advances

New Methodologies to Study DNA Repair Processes in Space and Time Within Living Cells

(2021) Siham Zentout et al.   Frontiers in Cell and Developmental Biology

The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer

(2021) Johannes Rudolph et al.   MOLECULAR CELL

The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome

(2021) Ivo A. Hendriks et al.   Nature Communications

Probing the Conformational Changes Associated with DNA Binding to PARP1

(2020) Johannes Rudolph et al.   BIOCHEMISTRY

Structural basis for allosteric PARP-1 retention on DNA breaks

(2020) Levani Zandarashvili et al.   SCIENCE

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo

(2020) Zhengping Shao et al.   NUCLEIC ACIDS RESEARCH

PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance

(2020) Maddison Rose et al.   Frontiers in Cell and Developmental Biology

The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks

(2020) Charlotte Blessing et al.   MOLECULAR CELL

Exploring and comparing adverse events between PARP inhibitors

(2019) Christopher J LaFargue et al.   LANCET ONCOLOGY

Q-FADD: A Mechanistic Approach for Modeling the Accumulation of Proteins at Sites of DNA Damage

(2019) Jyothi Mahadevan et al.   BIOPHYSICAL JOURNAL

Quantitating repair protein accumulation at DNA lesions: Past, present, and future

(2019) Jyothi Mahadevan et al.   DNA REPAIR

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks

(2019) Marie-Christine Caron et al.   Nature Communications

PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells

(2019) Sylvie M. Noordermeer et al.   TRENDS IN CELL BIOLOGY

Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits

(2018) Daniel T. Youmans et al.   GENES & DEVELOPMENT

PARP1 Stabilizes CTCF Binding and Chromatin Structure to Maintain Epstein Barr Virus Latency Type

(2018) Lena N. Lupey-Green et al.   JOURNAL OF VIROLOGY

Protein Dynamics in Complex DNA Lesions

(2018) Radoslav Aleksandrov et al.   MOLECULAR CELL

The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication

(2018) Hana Hanzlikova et al.   MOLECULAR CELL

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

(2018) George E. Ronson et al.   Nature Communications

Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance

(2018) Jone Michelena et al.   Nature Communications

Robust model-based analysis of single-particle tracking experiments with Spot-On

(2018) Anders S Hansen et al.   eLife

High speed of fork progression induces DNA replication stress and genomic instability

(2018) Apolinar Maya-Mendoza et al.   NATURE

PARP2 mediates branched poly ADP-ribosylation in response to DNA damage

(2018) Qian Chen et al.   Nature Communications

Poly(ADP-ribose) polymerase 1 searches DNA via a ‘monkey bar’ mechanism

(2018) Johannes Rudolph et al.   eLife

PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow

(2018) Todd A. Hopkins et al.   MOLECULAR CANCER RESEARCH

PARP1-dependent eviction of the linker histone H1 mediates immediate early gene expression during neuronal activation

(2017) Gajendra Kumar Azad et al.   JOURNAL OF CELL BIOLOGY

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1

(2017) Lili Liu et al.   NUCLEIC ACIDS RESEARCH

A map of protein dynamics during cell-cycle progression and cell-cycle exit

(2017) Sara Gookin et al.   PLOS BIOLOGY

CTCF and cohesin regulate chromatin loop stability with distinct dynamics

(2017) Anders S Hansen et al.   eLife

Molecular dynamics of histone H1

(2016) Thomas W. Flanagan et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres

(2016) Jens C. Schmidt et al.   CELL

PARP inhibitor combination therapy

(2016) Amy Dréan et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors

(2016) Ann-Gerd Thorsell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

(2016) Y. Pommier et al.   Science Translational Medicine

Poly(ADP-ribosyl)ation-dependent Transient Chromatin Decondensation and Histone Displacement following Laser Microirradiation

(2015) Hilmar Strickfaden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic Dissection of PARP1 Trapping and the Impact on In Vivo Tolerability and Efficacy of PARP Inhibitors

(2015) T. A. Hopkins et al.   MOLECULAR CANCER RESEARCH

A general method to improve fluorophores for live-cell and single-molecule microscopy

(2015) Jonathan B Grimm et al.   NATURE METHODS

Single molecule detection of PARP1 and PARP2 interaction with DNA strand breaks and their poly(ADP-ribosyl)ation using high-resolution AFM imaging

(2015) Maria V. Sukhanova et al.   NUCLEIC ACIDS RESEARCH

Genome-Wide Profiling of PARP1 Reveals an Interplay with Gene Regulatory Regions and DNA Methylation

(2015) Narasimharao Nalabothula et al.   PLoS One

Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells

(2014) Jiji Chen et al.   CELL

Automodification switches PARP-1 function from chromatin architectural protein to histone chaperone

(2014) U. M. Muthurajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib

(2013) J. Murai et al.   MOLECULAR CANCER THERAPEUTICS

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

Alternative Modes of Binding of Poly(ADP-ribose) Polymerase 1 to Free DNA and Nucleosomes

(2012) Nicholas J. Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased PARP-1 Association with DNA in Alkylation Damaged, PARP-Inhibited Mouse Fibroblasts

(2012) P. S. Kedar et al.   MOLECULAR CANCER RESEARCH

The DNA damage response and cancer therapy

(2012) Christopher J. Lord et al.   NATURE

Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1

(2012) M.-F. Langelier et al.   SCIENCE

Modeling Pharmacodynamic Response to the Poly(ADP-Ribose) Polymerase Inhibitor ABT-888 in Human Peripheral Blood Mononuclear Cells

(2011) Jiuping Ji et al.   PLoS One

PARP-1 Regulates Chromatin Structure and Transcription through a KDM5B-Dependent Pathway

(2010) Raga Krishnakumar et al.   MOLECULAR CELL

PARP1 ADP-ribosylates lysine residues of the core histone tails

(2010) Simon Messner et al.   NUCLEIC ACIDS RESEARCH

HaloTag: A Novel Protein Labeling Technology for Cell Imaging and Protein Analysis

(2008) Georgyi V. Los et al.   ACS Chemical Biology

Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation

(2008) W Lee Kraus   CURRENT OPINION IN CELL BIOLOGY

Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes

(2008) Arnauld Sergé et al.   NATURE METHODS

Highly inclined thin illumination enables clear single-molecule imaging in cells

(2008) Makio Tokunaga et al.   NATURE METHODS

Reciprocal Binding of PARP-1 and Histone H1 at Promoters Specifies Transcriptional Outcomes

(2008) R. Krishnakumar et al.   SCIENCE